Results 131 to 140 of about 43,287 (283)

The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice

Andrology, EarlyView.
Abstract Background RIBC1 (RIB43A domain with coiled‐coils 1) and RIBC2 (RIB43A domain with coiled‐coils 2) are homolog proteins of RIB43a which is localized to microtubules in the cilia and flagella of unicellular organisms. Cryo‐electron microscopy and artificial intelligence studies showed that RIBC1 and RIBC2 are microtubule inner proteins (MIPs ...
Kento Katsuma, Keisuke Shimada, Shingo Tonai, Daisuke Mashiko, Rie Iida‐Norita, Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +7 more
wiley   +1 more source

Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

eLife, 2015
In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axon ...
Urko del Castillo, Michael Winding, Wen Lu, Vladimir I Gelfand   +3 more
doaj   +1 more source

The I1 dynein-associated tether and tether head complex is a conserved regulator of ciliary motility

Molecular Biology of the Cell, 2018
We characterized the composition and three-dimensional structure of a conserved, dynein-associated tether/tether-head complex and its interactions with other ciliary structures.
Gang Fu, Qian Wang, Nhan Phan, Paulina Urbańska, E. Joachimiak, Jianfeng Lin, D. Wloga, D. Nicastro   +7 more
semanticscholar   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

erythro-9-[3-(2-Hydroxynonyl)]adenine is an inhibitor of sperm motility that blocks dynein ATPase and protein carboxylmethylase activities. [PDF]

, 1981
Philippe Bouchard, Stephen M. Penningroth, Ada S. Cheung, C. Gagnon, C. Wayne Bardin   +4 more
openalex   +1 more source

Residual flexibility in the topologically constrained multivalent complex between the GKAP scaffold and LC8 hub proteins

The FEBS Journal, EarlyView.
The scaffold protein GKAP and the hub protein LC8 form a well‐defined hexameric complex, with the stoichiometry of 2 GKAP : 2 LC8 dimers. NMR and molecular dynamics calculations confirm that the LC8‐binding segment of GKAP is intrinsically disordered even in the complex form.
Eszter Nagy‐Kanta, Zsófia E. Kálmán, Helena Tossavainen, Tünde Juhász, Fanni Farkas, József Hegedüs, Melinda Keresztes, Tamás Beke‐Somfai, Zoltán Gáspári, Perttu Permi, Bálint Péterfia   +10 more
wiley   +1 more source

CDKL5 regulates the initiation of retrograde axonal transport through CLIP170–dynactin complex formation

The FEBS Journal, EarlyView.
Activation of CLIP170 by CDKL5 in wild‐type (WT) cells promotes its open conformation and association with tyrosinated microtubule (MT) plus‐ends (+), where it works as a docking site to recruit the dynactin–dynein–cargo complex, promoting the initiation of retrograde transport. In knock‐out (KO) neurons, CLIP170 is mainly present in a closed (inactive)
Serena Baldin, Clara Carmone, Giorgia Valetti, Roberta De Rosa, Isabella Barbiero   +4 more
wiley   +1 more source

The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection.

PLoS Pathogens
During entry, human papillomavirus (HPV) traffics from the endosome to the trans Golgi network (TGN) and Golgi and then the nucleus to cause infection. Although dynein is thought to play a role in HPV infection, how this host motor recruits the virus to ...
Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai   +3 more
doaj   +1 more source

Cellular mechanisms of long‐term osmoregulation in magnocellular neurons

Journal of Neuroendocrinology, EarlyView.
Abstract Osmoregulation is an essential homeostatic process that maintains the osmolality of the extracellular fluid (ECF) close to a physiological setpoint. Vasopressin (VP) plays a key role in osmoregulation and is secreted by the magnocellular neurosecretory cells (MNCs) of the hypothalamus.
Kirk D. Haan, Thomas E. Fisher
wiley   +1 more source

Direction of force generated by the inner row of dynein arms on flagellar microtubules. [PDF]

, 1987
Laura A. Fox, Winfield S. Sale
openalex   +1 more source