Results 11 to 20 of about 29,365 (193)
FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex.
PLoS Genetics, 2022 Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Limei Wang +3 more
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Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility. [PDF]
PLoS ONE, 2017 Dynactin is a dynein-regulating protein that increases the processivity of dynein movement on microtubules. Recent studies have shown that a tripartite complex of dynein-dynactin-Bicaudal D2 is essential for highly processive movement.
Takuya Kobayashi +3 more
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Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. [PDF]
PLoS Genetics, 2007 Cytoplasmic dynein is a microtubule-dependent motor protein that functions in mitotic cells during centrosome separation, metaphase chromosome congression, anaphase spindle elongation, and chromosome segregation. Dynein is also utilized during interphase
Sean M O'Rourke +3 more
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A single protofilament is sufficient to support unidirectional walking of dynein and kinesin. [PDF]
PLoS ONE, 2012 Cytoplasmic dynein and kinesin are two-headed microtubule motor proteins that move in opposite directions on microtubules. It is known that kinesin steps by a 'hand-over-hand' mechanism, but it is unclear by which mechanism dynein steps.
Keitaro Shibata +6 more
doaj +1 more source
Biology Open, 2021 Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD).
Petra zur Lage +7 more
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Cytoplasmic dynein nomenclature [PDF]
The Journal of Cell Biology, 2005 A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes.
Pfister, K. Kevin +11 more
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Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Cytoplasmic dynein complex is a large multi-subunit microtubule (MT)-associated molecular motor involved in various cellular functions including organelle positioning, vesicle transport and cell division.
Takuya Kobayashi, Takashi Murayama
doaj +1 more source
Dynein light intermediate chains as pivotal determinants of dynein multifunctionality [PDF]
Journal of Cell Science, 2021 ABSTRACT In animal cells, a single cytoplasmic dynein motor mediates microtubule minus-end-directed transport, counterbalancing dozens of plus-end-directed kinesins. The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which engage the ...
Amrita Kumari +3 more
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Structural basis for cytoplasmic dynein-1 regulation by Lis1
eLife, 2022 The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor ...
John P Gillies +6 more
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Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport
Frontiers in Cell and Developmental Biology, 2022 Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the ...
Sharon R. Garrott +4 more
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