Results 61 to 70 of about 43,287 (283)
Interactions Between Active Matters and Endogenous Fields
Advanced Materials, EarlyView.This review synthesizes endogenous field information and computational methods in contexts such as cancer, wounds, and biofilms. It organizes NAMs and AAMs by sensing, transmitting, and executing functions, compares their limitations, and from these contrasts proposes design strategies for next‐generation AAMs, offering perspectives to foster ...
Jinwei Lin +6 more
wiley +1 more source
Bidirectional helical motility of cytoplasmic dynein around microtubules
eLife, 2014 Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo transport along microtubules (MTs). Dynein motility has previously been studied on surface-immobilized MTs in vitro, which constrains the motors to move in two dimensions ...
Sinan Can, Mark A Dewitt, Ahmet Yildiz
doaj +1 more source
The Generation of Dynein Networks by Multi-Layered Regulation and Their Implication in Cell Division
Frontiers in Cell and Developmental Biology, 2020 Cytoplasmic dynein-1 (hereafter referred to as dynein) is a major microtubule-based motor critical for cell division. Dynein is essential for the formation and positioning of the mitotic spindle as well as the transport of various cargos in the cell.
Takayuki Torisawa +3 more
doaj +1 more source
eLife, 2021 In eukaryotic cells, intracellular components are organized by the microtubule motors cytoplasmic dynein-1 (dynein) and kinesins, which are linked to cargos via adaptor proteins.
Jenna R Christensen +6 more
doaj +1 more source
LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo
Journal of Cell Biology, 2019 This study reveals the role of Lissencephaly-1 (LIS1) in cargo-adapter–mediated dynein activation. Furthermore, it discovers a role of LIS1 in switching dynein from an autoinhibited conformation to an open conformation that can be activated by dynactin ...
Rongde Qiu, Jun Zhang, Xin Xiang
semanticscholar +1 more source
Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain
Advanced Materials, EarlyView.A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng +11 more
wiley +1 more source
A mathematical understanding of how cytoplasmic dynein walks on microtubules [PDF]
Royal Society Open Science, 2018 Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles, a mechanical model
L. Trott +2 more
doaj +1 more source
Journal of Cell Biology, 2019 Intracellular transport can be driven by unidirectional motors acting in opposing directions, but how bidirectional transport of cargo is regulated is unclear. Kendrick et al.
Agnieszka A. Kendrick +9 more
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000 Dyneins are large multi-component microtubule-based molecular motors involved in many fundamental cellular processes including vesicular transport, mitosis and ciliary/flagellar beating. In order to achieve useful work, these enzymes must contain motor, cargo-binding and regulatory components. The ATPase and microtubule motor domains are located within
openaire +3 more sources
Slow Axonemal Dynein e Facilitates the Motility of Faster Dynein c [PDF]
Biophysical Journal, 2014 We highly purified the Chlamydomonas inner-arm dyneins e and c, considered to be single-headed subspecies. These two dyneins reside side-by-side along the peripheral doublet microtubules of the flagellum. Electron microscopic observations and single particle analysis showed that the head domains of these two dyneins were similar, whereas the tail ...
Kazuhiro Oiwa +3 more
openaire +3 more sources