Results 81 to 90 of about 43,287 (283)
Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein
Experimental and Molecular MedicineIntracellular retrograde transport in eukaryotic cells relies exclusively on the molecular motor cytoplasmic dynein 1. Unlike its counterpart, kinesin, dynein has a single isoform, which raises questions about its cargo specificity and regulatory ...
Jin-Gyeong Park +6 more
doaj +1 more source
BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M
Nature Communications, 2023 The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex while also connecting it to different cargos.
Núria Gallisà-Suñé +8 more
doaj +1 more source
Molecular mechanism of cytoplasmic dynein tension sensing
Nature Communications, 2019 Cytoplasmic dynein is the most complex cytoskeletal motor protein and is responsible for numerous biological functions. Essential to dynein’s function is its capacity to respond anisotropically to tension, so that its microtubule-binding domains bind ...
Lu Rao +3 more
semanticscholar +1 more source
The microtubule plus-end localization ofAspergillusdynein is important for dynein–early-endosome interaction but not for dynein ATPase activation [PDF]
Journal of Cell Science, 2010 Cytoplasmic dynein in filamentous fungi accumulates at microtubule plus-ends near the hyphal tip, which is important for minus-end-directed transport of early endosomes. It was hypothesized that dynein is switched on at the plus-end by cargo association.
Lei Zhuang +5 more
openaire +4 more sources
PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential
Cytoskeleton, EarlyView.ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah +2 more
wiley +1 more source
Neuronal migration defects in the Loa dynein mutant mouse
Neural Development, 2011 Background Cytoplasmic dynein and its regulatory proteins have been implicated in neuronal and non-neuronal cell migration. A genetic model for analyzing the role of cytoplasmic dynein specifically in these processes has, however, been lacking.
Ori-McKenney Kassandra M +1 more
doaj +1 more source
PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana
Cytoskeleton, EarlyView.ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes +6 more
wiley +1 more source
Kinesin and dynein use distinct mechanisms to bypass obstacles
eLife, 2019 Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S. Ferro +4 more
semanticscholar +1 more source
NuMA recruits dynein activity to microtubule minus-ends at mitosis
eLife, 2017 To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into
Christina L Hueschen +3 more
doaj +1 more source
PLoS Biology, 2019 All animal cells use the motor cytoplasmic dynein 1 (dynein) to transport diverse cargo toward microtubule minus ends and to organize and position microtubule arrays such as the mitotic spindle.
R. Celestino +10 more
semanticscholar +1 more source