Results 1 to 10 of about 9,978 (230)
Ciliary Dyneins and Dynein Related Ciliopathies [PDF]
Cells, 2021 Although ubiquitously present, the relevance of cilia for vertebrate development and health has long been underrated. However, the aberration or dysfunction of ciliary structures or components results in a large heterogeneous group of disorders in ...
Dinu Antony +2 more
doaj +4 more sources
N-Terminal Processing and Modification of Ciliary Dyneins [PDF]
Cells, 2023 Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku +2 more
doaj +2 more sources
PLoS Genetics, 2021 Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well established.
Rafał Bazan +5 more
doaj +3 more sources
Kinesin and dynein use distinct mechanisms to bypass obstacles
eLife, 2019 Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S Ferro +4 more
doaj +2 more sources
Structure and Function of Dynein’s Non-Catalytic Subunits [PDF]
CellsDynein, an ancient microtubule-based motor protein, performs diverse cellular functions in nearly all eukaryotic cells, with the exception of land plants.
Lu Rao, Arne Gennerich
doaj +2 more sources
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
doaj +1 more source
Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein
Scientific Reports, 2022 Eukaryotic cilia/flagella are cellular bio-machines that drive the movement of microorganisms. Molecular motor axonemal dyneins in the axoneme, which consist of an 9 + 2 arrangement of microtubules, play an essential role in ciliary beating.
Shin Yamaguchi +2 more
doaj +1 more source
Predicting the locations of force-generating dyneins in beating cilia and flagella
Frontiers in Cell and Developmental Biology, 2022 Cilia and flagella are slender cylindrical organelles whose bending waves propel cells through fluids and drive fluids across epithelia. The bending waves are generated by dynein motor proteins, ATPases whose force-generating activity changes over time ...
Jonathon Howard +7 more
doaj +1 more source
The Generation of Dynein Networks by Multi-Layered Regulation and Their Implication in Cell Division
Frontiers in Cell and Developmental Biology, 2020 Cytoplasmic dynein-1 (hereafter referred to as dynein) is a major microtubule-based motor critical for cell division. Dynein is essential for the formation and positioning of the mitotic spindle as well as the transport of various cargos in the cell.
Takayuki Torisawa +3 more
doaj +1 more source
Dynein-Inspired Multilane Exclusion Process with Open Boundary Conditions
Entropy, 2021 Motivated by the sidewise motions of dynein motors shown in experiments, we use a variant of the exclusion process to model the multistep dynamics of dyneins on a cylinder with open ends.
Riya Nandi, Uwe C. Täuber, Priyanka
doaj +1 more source