Results 11 to 20 of about 5,150 (192)
Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor. [PDF]
Cytoskeleton (Hoboken)ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
King SM.
europepmc +2 more sources
Dynein and dynein-related genes [PDF]
Cell Motility and the Cytoskeleton, 1998 Dyneins are large, multisubunit ATPases that interact with microtubules to generate force. Dyneins move eukaryotic cilia and flagella and are in the cytoplasm, where they are involved in the transport of particles and organelles along microtubules and in the transport of condensed chromosomes during mitosis [reviewed in Holzbaur et al., 1994; Gibbons ...
openaire +3 more sources
The World Journal of Men's Health, 2022 The protein encoded by dynein axonemal heavy chain 1 (DNAH1) is a part of dynein, which regulates the function of cilia and sperm flagella.
Bao-Jun Zhuang +10 more
doaj +1 more source
eLife, 2018 Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi +3 more
doaj +1 more source
Structure of a microtubule-bound axonemal dynein
Nature Communications, 2021 Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood.
Travis Walton, Hao Wu, Alan Brown
doaj +1 more source
eLife, 2017 Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-
Jonathan B Steinman +21 more
doaj +1 more source
PLoS Genetics, 2020 Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse.
Takahiro Ide +12 more
doaj +1 more source
Cytoplasmic dynein nomenclature [PDF]
The Journal of Cell Biology, 2005 A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes.
Pfister, K. Kevin +11 more
openaire +3 more sources
Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. [PDF]
PLoS ONE, 2012 Flagellum motility is critical for normal human development and for transmission of pathogenic protozoa that cause tremendous human suffering worldwide.
Louise C Hughes +3 more
doaj +1 more source
Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates
eLife, 2023 Outer arm dynein (OAD) is the main force generator of ciliary beating. Although OAD loss is the most frequent cause of human primary ciliary dyskinesia, the docking mechanism of OAD onto the ciliary doublet microtubule (DMT) remains elusive in ...
Hiroshi Yamaguchi +2 more
doaj +1 more source