Ecological Contexts of Index Cases and Spillover Events of Different Ebolaviruses
PLoS Pathogens, 2016 Ebola virus disease afflicts both human and animal populations and is caused by four ebolaviruses. These different ebolaviruses may have distinct reservoir hosts and ecological contexts that determine how, where, and when different ebolavirus spillover ...
Seth D Judson +2 more
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Epidemiology of Ebolaviruses from an Etiological Perspective [PDF]
Pathogens, 2023 Since the inception of the ebolavirus in 1976, 32 outbreaks have resulted in nearly 15,350 deaths in more than ten countries of the African continent. In the last decade, the largest (2013–2016) and second largest (2018–2020) ebolavirus outbreaks have ...
Sahil Jain +4 more
doaj +3 more sources
Tenacious Researchers Identify a Weakness in All Ebolaviruses. [PDF]
MBio, 2018 The Ebolavirus genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive.
Rebecca M DuBois
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Structural Basis for Differential Neutralization of Ebolaviruses
Viruses, 2012 There are five antigenically distinct ebolaviruses that cause hemorrhagic fever in humans or non-human primates (Ebola virus, Sudan virus, Reston virus, Taï Forest virus, and Bundibugyo virus).
Takao Hashiguchi +2 more
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Engineered bispecific antibodies achieve broad and potent protection against multiple ebolavirus species [PDF]
Emerging Microbes and InfectionsEbolaviruses, including EBOV, SUDV, and BDBV, cause severe hemorrhagic fever, yet currently licensed monoclonal antibody (mAb) therapies against EBOV lack cross-species efficacy.
Jinge Zhou +15 more
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Recombinant Bombali ebolavirus in cynomolgus macaques as a survival model of Ebola virus disease [PDF]
Nature CommunicationsEbolaviruses are known to cause severe hemorrhagic fever in humans. A new ebolavirus species, Bombali orthoebolavirus (BOMV), was recently detected in bats from Sierra Leone, Kenya, Guinea, Mozambique, and Tanzania.
Jacquelyn Turcinovic +14 more
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Protocol for quantification of intercellular connection transmission in ebolavirus infections using ImageJ [PDF]
STAR ProtocolsSummary: Previous work demonstrates that ebolaviruses can spread to neighboring cells through intercellular connections. Here, we present a protocol to quantify the intercellular spread of ebolaviruses via immunofluorescence.
Rodrigo I. Santos, Alexander Bukreyev
doaj +2 more sources
Infection prevention and control studies for care of patients with suspected or confirmed filovirus disease in healthcare settings, with focus on Ebola and Marburg: an integrative review [PDF]
BMJ Public HealthObjective To review evidence pertaining to methods for preventing healthcare-associated filovirus infections (including the survivability of filoviruses in clinical environments and the chlorine concentration required for effective disinfection), and to ...
Eugene T Richardson +5 more
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Evaluation of Probenecid Against Filovirus Replication in Vero E6 Cells [PDF]
VirusesIn human and non-human primates, filoviruses, e.g., Ebolaviruses, cause severe hemorrhagic fever for which there are few therapeutic options. While there are licensed vaccines and therapeutics for Ebola virus disease, there is no approved vaccine or ...
Kendra Alfson +4 more
doaj +2 more sources
RNA Editing as a General Trait of Ebolaviruses. [PDF]
Journal of Infectious Diseases, 2023 Heinz Feldmann +2 more
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