Results 41 to 50 of about 1,365 (152)

Serological Evidence of Exposure to Ebolaviruses in Domestic Pigs from Guinea [PDF]

, 2019
The genus Ebolavirus comprises several virus species with zoonotic potential and varying pathogenicity for humans. Ebolaviruses are considered to circulate in wildlife with occasional spillover events into the human population which then often leads to ...
Troupin, Cécile, Fischer, Kerstin, Groschup, Martin H., Camara, Alimou, Fehling, Sarah, Groschup, Martin, Strecker, Thomas, Diederich, Sandra, Tordo, Noel, Fehling, Sarah K.   +9 more
core   +1 more source

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Viruses, 2021
Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as ...
Katendi Changula, Edgar Simulundu, Boniface Pongombo Lombe, Eri Nakayama, Hiroko Miyamoto, Yuji Takahashi, Hirofumi Sawa, Chuma Simukonda, Bernard M. Hang’ombe, Ayato Takada   +9 more
doaj   +1 more source

Ebolavirus evolution and emergence are associated with land use change. [PDF]

Ecol Monogr
Abstract Anthropogenic land use change facilitates disease emergence by altering the interface between humans and pathogen reservoirs and is hypothesized to drive pathogen evolution. Here, we show a positive association between land use change and the evolution and dispersal of Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV).
Lange CE, Barnum TR, McIver DJ, LeBreton M, Karen Saylors, Kumakamba C, Lowes S, Montero E, Cohen RL.   +8 more
europepmc   +2 more sources

Investigating the Circulation of Ebola Viruses in Bats during the Ebola Virus Disease Outbreaks in the Equateur and North Kivu Provinces of the Democratic Republic of Congo from 2018

Pathogens, 2021
With 12 of the 31 outbreaks, the Democratic Republic of Congo (DRC) is highly affected by Ebolavirus disease (EVD). To better understand the role of bats in the ecology of Ebola viruses, we conducted surveys in bats during two recent EVD outbreaks and in
Audrey Lacroix, Placide Mbala Kingebeni, Simon Pierre Ndimbo Kumugo, Guy Lempu, Christelle Butel, Laetitia Serrano, Nicole Vidal, Guillaume Thaurignac, Amandine Esteban, Daniel Mukadi Bamuleka, Jacques Likofata, Eric Delaporte, Jean-Jacques Muyembe Tamfum, Ahidjo Ayouba, Martine Peeters, Steve Ahuka Mundeke   +15 more
doaj   +1 more source

Ebolavirus Vaccines: Progress in the Fight Against Ebola Virus Disease

Cellular Physiology and Biochemistry, 2015
Ebolaviruses are highly infectious pathogens that cause lethal Ebola virus disease (EVD) in humans and non-human primates (NHPs). Due to their high pathogenicity and transmissibility, as well as the potential to be misused as a bioterrorism agent ...
Xiao-Xin Wu, Hang-Ping Yao, Nan-Ping Wu, Hai-Nv Gao, Hai-Bo Wu, Chang-Zhong Jin, Xiang-Yun Lu, Tian-Shen Xie, Lan-Juan Li   +8 more
doaj   +1 more source

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. [PDF]

PLoS Pathogens, 2015
The filoviruses, which include the marburg- and ebolaviruses, have caused multiple outbreaks among humans this decade. Antibodies against the filovirus surface glycoprotein (GP) have been shown to provide life-saving therapy in nonhuman primates, but ...
Marnie L Fusco, Takao Hashiguchi, Robyn Cassan, Julia E Biggins, Charles D Murin, Kelly L Warfield, Sheng Li, Frederick W Holtsberg, Sergey Shulenin, Hong Vu, Gene G Olinger, Do H Kim, Kevin J Whaley, Larry Zeitlin, Andrew B Ward, Cory Nykiforuk, M Javad Aman, Jody D Berry, Erica Ollmann Saphire   +18 more
doaj   +1 more source

Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development

Frontiers in Immunology, 2022
Monoclonal antibodies (mAbs) have proven effective for the treatment of ebolavirus infection in humans, with two mAb-based drugs Inmazeb™ and Ebanga™ receiving FDA approval in 2020.
Charles D. Murin, Pavlo Gilchuk, James E. Crowe, James E. Crowe, James E. Crowe, Andrew B. Ward   +5 more
doaj   +1 more source

Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope

mBio, 2018
Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in complex with Ebola ...
Brandyn R. West, Crystal L. Moyer, Liam B. King, Marnie L. Fusco, Jacob C. Milligan, Sean Hui, Erica Ollmann Saphire   +6 more
doaj   +1 more source

Development and Structural Analysis of Antibody Therapeutics for Filoviruses

Pathogens, 2022
The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts.
Xiaoying Yu, Erica Ollmann Saphire
doaj   +1 more source

Investigating Ebola virus pathogenicity using molecular dynamics

BMC Genomics, 2017
Background Ebolaviruses have been known to cause deadly disease in humans for 40 years and have recently been demonstrated in West Africa to be able to cause large outbreaks.
Morena Pappalardo, Francesca Collu, James Macpherson, Martin Michaelis, Franca Fraternali, Mark N. Wass   +5 more
doaj   +1 more source