Results 141 to 150 of about 12,362 (197)

Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata

Nature Communications
Multidrug resistance in the pathogenic fungus Candida glabrata is a growing global threat. Here, we study mechanisms of multidrug resistance in this pathogen. Exposure of C.
Taiga Miyazaki, Shintaro Shimamura, Yohsuke Nagayoshi, Hironobu Nakayama, Akihiro Morita, Yutaka Tanaka, Yasuhiko Matsumoto, Tatsuo Inamine, Hiroshi Nishikawa, Nana Nakada, Makoto Sumiyoshi, Tatsuro Hirayama, Shigeru Kohno, Hiroshi Mukae   +13 more
doaj   +1 more source

Development and Validation of TaqMan Chemistry Probe-Based Rapid Assay for the Detection of Echinocandin-Resistance in Candida auris. [PDF]

J Clin Microbiol, 2023
Zhu Y, Hager KM, Manjari SR, Banavali NK, Chaturvedi V, Chaturvedi S.   +5 more
europepmc   +1 more source

In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022. [PDF]

Euro Surveill, 2023
Codda G, Willison E, Magnasco L, Morici P, Giacobbe DR, Mencacci A, Marini D, Mikulska M, Bassetti M, Marchese A, Di Pilato V.   +10 more
europepmc   +1 more source

Emergence of multidrug-resistant Candidozyma auris in southern China: a multicenter study on genetic diversity and antifungal resistance

Frontiers in Microbiology
PurposeCandidozyma auris (C. auris) is an emerging fungal pathogen that is resistant to multiple drugs and poses a serious threat to global health. This study aimed to investigate the genetic diversity and antifungal resistance profiles of C.
Penghao Guo, Jingchun Fang, Ruizhi Wang, Weihong Lin, Yueting Jiang, Jun Long, Lingjuan Chen, Xudong Huang, Kang Liao, Yaqin Peng   +9 more
doaj   +1 more source

Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris. [PDF]

mBio, 2022
Jenull S, Shivarathri R, Tsymala I, Penninger P, Trinh PC, Nogueira F, Chauhan M, Singh A, Petryshyn A, Stoiber A, Chowdhary A, Chauhan N, Kuchler K.   +12 more
europepmc   +1 more source

Mutational landscape and molecular bases of echinocandin resistance

AbstractOne of the front-line drug classes used to treat invasive fungal infections is echinocandins, which target the fungal-specific beta-glucan synthase (Fks). Treatment failure due to resistance often coincides with mutations in three protein regions defined as hotspots.
Romain Durand, Alexandre G. Torbey, Mathieu Giguere, Alicia Pageau, Alexandre K. Dubé, Patrick Lagüe, Christian R. Landry   +6 more
openaire   +1 more source

The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans. [PDF]

PLoS Pathog, 2021
Sah SK, Hayes JJ, Rustchenko E.
europepmc   +1 more source

Prevalence of Antifungal Resistance, Genetic Basis of Acquired Azole and Echinocandin Resistance, and Genotyping of Candida krusei Recovered from an International Collection. [PDF]

Antimicrob Agents Chemother, 2022
Khalifa HO, Hubka V, Watanabe A, Nagi M, Miyazaki Y, Yaguchi T, Kamei K.   +6 more
europepmc   +1 more source

Echinocandins: Resistance Mechanisms [PDF]

, 2015
Santosh Katiyar, Thomas Edlind
openaire   +1 more source

Case Report: Echinocandin-Resistance Candida glabrata FKS Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer. [PDF]

Front Oncol, 2021
Szymankiewicz M, Kamecki K, Jarzynka S, Koryszewska-Bagińska A, Olędzka G, Nowikiewicz T.   +5 more
europepmc   +1 more source