Results 91 to 100 of about 17,763 (261)

[Echinocandins].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2012
The echinocandins, caspofugin, micafungin, and anidulafungin, are lipopeptides that inhibit fungal growth by binding to β - (1.3) d glucan synthase. This enzyme is responsible for the formation of the peptidoglycan cell wall, and it is essential in fungi such as Candida spp, but less important in the case of Aspergillus and Fusarium species.
Jorge A, Cortés L, July A, Russi N
openaire   +1 more source

SIP‐SRS Imaging of Cell Wall Synthesis Identifies a Synergy between Micafungin and Amphotericin B

Advanced Science, Volume 12, Issue 48, December 29, 2025.
We employed glucose‐d7–based stable isotope probe‐assisted SRS microscopy (SIP‐SRS) C–D imaging to visualize fungal cell wall synthesis and remodeling under antifungal treatment. Amphotericin B (AmB) induced notable daughter cell wall thickening, prompting a combinational therapy with AmB and micafungin.
Meng Zhang, Yuewei Zhan, Haonan Lin, Jiyang Chen, Mohamed N. Seleem, Michael Mansour, Ji‐Xin Cheng   +6 more
wiley   +1 more source

Core histones govern echinocandin susceptibility in Candida glabrata

Microbiology Spectrum
The dynamic chromatin structure regulates many biological processes including gene expression, DNA repair, and genome stability in eukaryotic cells.
Aditi Pareek, Rupinder Kaur
doaj   +1 more source

Recent Insights into the Paradoxical Effect of Echinocandins

Journal of Fungi, 2017
Echinocandin antifungals represent one of the most important drug classes for the treatment of invasive fungal infections. The mode of action of the echinocandins relies on inhibition of the β-1,3-glucan synthase, an enzyme essentially required for the ...
Johannes Wagener, Veronika Loiko
doaj   +1 more source

Reduced Cdc14 phosphatase activity impairs septation, hyphal differentiation and pathogenesis and causes echinocandin hypersensitivity in Candida albicans [PDF]

, 2022
Kedric L. Milholland, Ahmed AbdelKhalek, Kortany M. Baker, Smriti Hoda, Andrew G. DeMarco, Noelle H. Naughton, Angela N Koeberlein, Gabrielle R. Lorenz, Kartikan Anandasothy, Antonio Esperilla-Muñoz, Sanjeev Narayanan, Jaime Correa‐Bordes, Scott Briggs, Mark C. Hall   +13 more
openalex   +1 more source

Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross‐Pathogen Diagnostic Universality

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Modular nanosensing platforms utilize nanomaterials and functionalized interfaces to amplify trace different pathogens (like tuberculosis) antigen capture, suppress matrix interference, and enable multiplex detection. Their portability and cost‐effectiveness support rapid screening in resource‐limited settings and real‐time monitoring, advancing high ...
Mei Li, Yuxin Luo, Wenqiang Li, Yiqing Wang, Yunze Tai, Zhiping Deng, Yao Luo   +6 more
wiley   +1 more source

A Prospective Surveillance Study of Candidaemia : Epidemiology, Risk Factors, Antifungal Treatment and Outcome in Hospitalized Patients [PDF]

, 2016
Funding This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z. Data collection was supported by a grant from Pfizer.
Deshpande, Ashutosh, Hanson, Mary F., Johnson, Elizabeth M., Jones, Brian L., Munro, Carol A., Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Williams, Craig   +8 more
core   +2 more sources

Antifungal Susceptibility Profile of Aspergillus Strains Isolated From the Lower Respiratory Tract in Eastern Indian Patients: A Hospital‐Based Study

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Treatment for chronic to invasive pulmonary aspergillosis typically involves azole antifungal drugs, although studies have shown varying minimum inhibitory concentrations (MIC) for these medications, with a growing concern over voriconazole resistance.
Aishwarya Nikhil, Sradha Choudhury, Mohit Bhatia, Atul Kumar Tiwari, Ritika Srivastava, Abhirami Prasad, Ragini Tilak, Munesh K. Gupta, Roger J. Narayan   +8 more
wiley   +1 more source

Rezafungin—Mechanisms of Action, Susceptibility and Resistance: Similarities and Differences with the Other Echinocandins

Journal of Fungi, 2020
Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-acting echinocandins. It has several advantages over the already approved by
Guillermo Garcia-Effron
doaj   +1 more source

Antibiotic Resistance Crisis: From Bacterial Bioprospecting to Artificial Intelligence

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Overview of the global antimicrobial resistance crisis and interdisciplinary approaches to address it, including bioprospecting, innovative cultivation strategies, genomics and bioinformatics, artificial intelligence and machine learning, alternative antimicrobial therapies, and educational strategies.
I. C. Cunha‐Ferreira, C. S. Vizzotto, J. Peixoto, R. H. Krüger   +3 more
wiley   +1 more source