Results 51 to 60 of about 408 (132)

Pigment Cell Differentiation in Sea Urchin Blastula-Derived Primary Cell Cultures

Marine Drugs, 2014
The quinone pigments of sea urchins, specifically echinochrome and spinochromes, are known for their effective antioxidant, antibacterial, antifungal, and antitumor activities. We developed in vitro technology for inducing pigment differentiation in cell
Natalya V. Ageenko, Konstantin V. Kiselev, Pavel S. Dmitrenok, Nelly A. Odintsova   +3 more
doaj   +1 more source

A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells

Marine Drugs, 2018
Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome.
Hyoung Kyu Kim, Sung Woo Cho, Hye Jin Heo, Seung Hun Jeong, Min Kim, Kyung Soo Ko, Byoung Doo Rhee, Natalia P. Mishchenko, Elena A. Vasileva, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +11 more
doaj   +1 more source

SUPRESSION OF MICROSOMAL OXIDATION WEAKENS HISTOCHROME’S DIURETIC EFFECT AT RATS

Бюллетень сибирской медицины, 2013
Histochrome is the medicinal form of echinochrome (2, 3, 5, 6, 8-pentahydroxy-7-ethyl-1,4-naphthoquinone). Arisen during clinical application of the drug questions concerning its biotransformation have predetermined the aim of this research: to study ...
O. S. Talalaeva, A. Yu. Zharikov, Ya. F. Zverev, S. A. Fedoreyev, V. M. Bryukhanov, V. V. Lampatov   +5 more
doaj   +1 more source

Antiviral Potential of Sea Urchin Aminated Spinochromes against Herpes Simplex Virus Type 1

Marine Drugs, 2020
Herpes simplex virus type 1 (HSV-1) is one of the most prevalent pathogens worldwide requiring the search for new candidates for the creation of antiherpetic drugs.
Natalia P. Mishchenko, Natalia V. Krylova, Olga V. Iunikhina, Elena A. Vasileva, Galina N. Likhatskaya, Evgeny A. Pislyagin, Darya V. Tarbeeva, Pavel S. Dmitrenok, Sergey A. Fedoreyev   +8 more
doaj   +1 more source

Comparative Analysis of the Functional Properties of Films Based on Carrageenans, Chitosan, and Their Polyelectrolyte Complexes

Marine Drugs, 2021
The influence of the structural features of carrageenan on the functional properties of the films was studied. The carrageenans and chitosan films, as well as three-layer films containing a polyelectrolyte complex (PEC) of the two, were prepared.
Aleksandra V. Volod’ko, Viktoriya N. Davydova, Valentina A. Petrova, Dmitry P. Romanov, Evgeniya A. Pimenova, Irina M. Yermak   +5 more
doaj   +1 more source

The Teratogenic Mechanism of Echinochrome as a Hypoglycemic Agent on Wistar Rats [PDF]

The Open Biomarkers Journal, 2019
Background: Echinochrome (Ech) is the active ingredient in the Histochrome drug, which possesses strong antioxidant, hypolipidemic and hypoglycemic activity. Objective: The present work aimed to characterize the malformations induced by ...
Ayman S. Mohamed, Eman Y. Salah EL Din, Neveen A. Farag, Abdel Rahman A. Tawfik   +3 more
openaire   +1 more source

Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells

Marine Drugs, 2019
Cardiac progenitor cells (CPCs) are resident stem cells present in a small portion of ischemic hearts and function in repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing cell viability.
Ji Hye Park, Na-Kyung Lee, Hye Ji Lim, Sinthia Mazumder, Vinoth Kumar Rethineswaran, Yeon-Ju Kim, Woong Bi Jang, Seung Taek Ji, Songhwa Kang, Da Yeon Kim, Le Thi Hong Van, Ly Thanh Truong Giang, Dong Hwan Kim, Jong Seong Ha, Jisoo Yun, Hyungtae Kim, Jin Han, Natalia P. Mishchenko, Sergey A. Fedoreyev, Elena A. Vasileva, Sang Mo Kwon, Sang Hong Baek   +21 more
doaj   +1 more source

Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress

Marine Drugs, 2018
Doxorubicin, an anthracycline from Streptomyces peucetius, exhibits antitumor activity against various cancers. However, doxorubicin is cardiotoxic at cumulative doses, causing increases in intracellular reactive oxygen species in the heart.
Chang Shin Yoon, Hyoung Kyu Kim, Natalia P. Mishchenko, Elena A. Vasileva, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +6 more
doaj   +1 more source

ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

Медицинская иммунология, 2014
. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating  complexes  (TI-complexes),  and  an  individual  antigen,  i.e.,  monomeric  and  trimeric forms of porin isolated from Yersinia ...
A. V. Tsybulsky, A. M. Popov, O. Yu. Portnyagina, A. A. Artyukov, N. M. Sanina, A. N. Mazeyka, E. Y. Kostetsky   +6 more
doaj   +1 more source

Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids

Ecotoxicology and Environmental Safety
Echinochrome A (EchA), a marine-derived natural product, has shown promise in treating cardiovascular and inflammatory diseases due to its antioxidant and anti-inflammatory properties. However, its cardiac safety remains underexplored.
Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee   +11 more
doaj   +1 more source