Results 91 to 100 of about 469,615 (331)

β-Adrenoceptor Signaling Activation Improves Bladder Fibrosis by Inhibiting Extracellular Matrix Deposition of Bladder Outlet Obstruction

Frontiers in Bioscience-Landmark
Background: Partial bladder outlet obstruction (pBOO) causes deposition of extracellular matrix (ECM), promotes bladder fibrosis, and decreases bladder compliance. Methods:
Junyu Lai, Guo Chen, Hongwei Su, Qing He, Kaiwen Xiao, Banghua Liao, Jianzhong Ai   +6 more
doaj   +1 more source

Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded

Cancers, 2020
Simple Summary The extracellular matrix (ECM) has emerged as a critical part of the tumor microenvironment. This glycoprotein- and proteoglycan-rich part of the tumor serves as a niche for the enrichment of cancer stem cells that can drive resistance to ...
K. Kesh, Vineet K Gupta, B. Durden, V. Garrido, Beatriz Mateo-Victoriano, Shweta P Lavania, Sulagna Banerjee   +6 more
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Causality between Economic Growth and Consumption of Natural Gas in I. R. Iran [PDF]

Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2012
This study investigates interactions between economic growth and natural gas consumption, using times series data. The paper uses vector error correction technique and Johansen Co-integration test for the period 1353-1386.
Teymoor Mohammadi, Azadeh Bordbar, Alireza Daghighi Asli   +2 more
doaj  

Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis

Developmental Cell, 2020
Summary The extracellular matrix (ECM) is a polymer network hypothesized to form a stable cellular scaffold. While the ECM can undergo acute remodeling during embryogenesis, it is experimentally difficult to determine whether basal turnover is also ...
Yutaka Matsubayashi, B. J. Sánchez-Sánchez, Stefania Marcotti, Eduardo Serna-Morales, Anca Dragu, María-del-Carmen Díaz-de-la-Loza, G. Vizcay-Barrena, R. Fleck, B. Stramer   +8 more
semanticscholar   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

ECM: chemoattraction but not adhesion [PDF]

Blood, 2013
The mechanisms that regulate 3-dimensional (3D) neutrophil chemotaxis are poorly understood. In this issue of Blood, Afonso et al demonstrate that the collagen receptor Discoidin domain receptor 2 (DDR2) promotes neutrophil chemotaxis in 3D by triggering matrix metalloproteinase (MMP) activity and the generation of chemotactic collagen peptides.
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source