Results 81 to 90 of about 472,334 (294)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Responses of ectomycorrhizal fungi to changes in carbon and nutrient availability [PDF]

open access: yes, 2001
Ectomycorrhizal (ECM) fungi may receive 20% of the total C fixed by their host plants and are essential components of host nutrient acquisition. As a consequence of the vast physiological diversity that exists among ECM fungi, changes in community ...
Fransson, Petra M.A.
core  

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

ECM: chemoattraction but not adhesion [PDF]

open access: yesBlood, 2013
The mechanisms that regulate 3-dimensional (3D) neutrophil chemotaxis are poorly understood. In this issue of Blood, Afonso et al demonstrate that the collagen receptor Discoidin domain receptor 2 (DDR2) promotes neutrophil chemotaxis in 3D by triggering matrix metalloproteinase (MMP) activity and the generation of chemotactic collagen peptides.
openaire   +2 more sources

Finding ECM-friendly curves through a study of Galois properties [PDF]

open access: yes, 2012
In this paper we prove some divisibility properties of the cardinality of elliptic curves modulo primes. These proofs explain the good behavior of certain parameters when using Montgomery or Edwards curves in the setting of the elliptic curve method (ECM)
Barbulescu, Razvan   +4 more
core   +3 more sources

Chewing up the wood-wide web : selective grazing on ectomycorrhizal fungi by collembola [PDF]

open access: yes, 2015
This work was supported by the Natural Environment Research Council (NE/C507510/1). We thank S. Van der Linde, A. Sim, L. Shivraj, and P.
Clarisse Kanters   +7 more
core   +2 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

open access: yes4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

External loading determines specific ECM genes regulation [PDF]

open access: yes, 2006
Bio artificial matrices embedded with cells are simulated in bioreactors to facilitate ECM production. As cells attach, they develop forces, which are dependent on cell type and matrix stiffness.
Brown, R   +3 more
core  

An investigation of the Eigenvalue Calibration Method (ECM) using GASP for non-imaging and imaging detectors [PDF]

open access: yes, 2015
Polarised light from astronomical targets can yield a wealth of information about their source radiation mechanisms, and about the geometry of the scattered light regions.
Hallinan, Gregg   +4 more
core   +3 more sources

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