Results 61 to 70 of about 324,854 (299)

The Influence of Leadership on the Projectification of the Public Construction Sector in Germany

Buildings, 2023
While the projectification of society continues to evolve, it is clearly lagging behind in the public construction sector in Germany. The purpose of the research upon which this article is based was to reveal the role that leadership has on the ...
Gunnar Jürgen Lühr, Reinhard Friedrich Wagner, Mladen Radujković   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Effect of Foreign Direct Investment, Human Development and Macroeconomic Condition on Economic Growth: Evidence from Indonesia

Journal of Indonesian Applied Economics, 2020
The national economic growth that is quite high is not necessarily detached from the existence of important issues such as limited accumulation of national saving capital, domestic needs that are still highly dependent on imported goods, weak of export ...
M. Rismawan Ridha, Novia Budi Parwanto
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

β-Adrenoceptor Signaling Activation Improves Bladder Fibrosis by Inhibiting Extracellular Matrix Deposition of Bladder Outlet Obstruction

Frontiers in Bioscience-Landmark
Background: Partial bladder outlet obstruction (pBOO) causes deposition of extracellular matrix (ECM), promotes bladder fibrosis, and decreases bladder compliance. Methods:
Junyu Lai, Guo Chen, Hongwei Su, Qing He, Kaiwen Xiao, Banghua Liao, Jianzhong Ai   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Histology of SIS-ECM.

, 2016
(A) H&E staining of SIS-ECM in medium for 30 min (left), non-seeded SIS-ECM (right) and SIS-ECM seeded with hMSCs (middle). Seeded hMSCs were observed to grow in layers on the surface of SIS-ECM with occasional migration within the matrix (denoted by ...
Xin Lin (149944), Leigh G. Griffiths (2607973), Tye Petrie (2607976), Alycia Clark (2607979), Chia Wei Chang (2607982), Claus S. Sondergaard (491708)   +5 more
core   +1 more source

Causality between Economic Growth and Consumption of Natural Gas in I. R. Iran [PDF]

Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2012
This study investigates interactions between economic growth and natural gas consumption, using times series data. The paper uses vector error correction technique and Johansen Co-integration test for the period 1353-1386.
Teymoor Mohammadi, Azadeh Bordbar, Alireza Daghighi Asli   +2 more
doaj  

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source