Results 71 to 80 of about 378,182 (255)

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

open access: yes4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Long-run strong-exogeneity [PDF]

open access: yes
This note supplements the paper by Pradel and Rault (2003) "Exogeneity in VAR-ECM models with purely exogenous long-run paths", Oxford Bulletin of Economics and Statistics.
Christophe Rault
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Evaluation of Abrams curve in agricultural sector using the NARDL approach

open access: yesOpen Agriculture
Developing countries have made significant economic progress in the recent decades, but agriculture sector has not produced enough value add for the economy due to the low productivity in this sector, which contributes to poverty and delays in the growth
Zeraatkish Seyed Yaghoub   +2 more
doaj   +1 more source

ANALISIS INTEGRASI PASAR KOMODITAS CABAI RAWIT DI PROVINSI GORONTALO

open access: yesSepa
This study aims to analyze the vertical market integration of cayenne pepper in Gorontalo Province. The sampling method is based on the availability of cayenne pepper price data over a period of 4 years (2017 to 2020).
Yuliana Bakari, Echan Adam, Sirin Aditia
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

open access: yesFEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt   +2 more
wiley   +1 more source

The result of ECM modelling.

open access: yes, 2021
The result of ECM modelling.
A. H. M. Belayeth Hussain (11592520)   +4 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Schnelles Mikrofräsen mittels Jet-ECM

open access: yes, 2022
S.54-55Electrochemical Machining (ECM) is a particularly suitable procedure for micro manufacturing. Main advantage compared to other procedures is the possibility to machine metallic work pieces without thermal or mechanical impact and the independence ...
Martin, Andre   +4 more
core   +1 more source

The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine

open access: yesSultan Qaboos University Medical Journal, 2011
Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Moustapha Hassan   +2 more
doaj  

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