Results 51 to 60 of about 230,272 (282)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Causality between Economic Growth and Consumption of Natural Gas in I. R. Iran [PDF]

Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2012
This study investigates interactions between economic growth and natural gas consumption, using times series data. The paper uses vector error correction technique and Johansen Co-integration test for the period 1353-1386.
Teymoor Mohammadi, Azadeh Bordbar, Alireza Daghighi Asli   +2 more
doaj  

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism [PDF]

Open Biology, 2018
The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children.
Max D. Knickmeyer, Juan L. Mateo, Priska Eckert, Eleni Roussa, Belal Rahhal, Aimee Zuniga, Kerstin Krieglstein, Joachim Wittbrodt, Stephan Heermann   +8 more
doaj   +1 more source

ECM analog technology a simple tool for exploring cell-ECM dynamics [PDF]

Frontiers in Bioscience, 2012
Cells in a functional tissue display a highly interactive relation with their neighboring cells and associated biochemical milieu. Serious disruption in the existing homeostatic balance in the extra-cellular matrix (ECM) may lead to abnormal response by the cells.
Ranjna C, Dutta, Aroop K, Dutta
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ECM on Graphics Cards [PDF]

, 2009
This paper reports record-setting performance for the elliptic-curve method of integer factorization: for example, 926.11 curves/second for ECM stage 1 with B 1¿=¿8192 for 280-bit integers on a single PC. The state-of-the-art GMP-ECM software handles 124.71 curves/second for ECM stage 1 with B 1¿=¿8192 for 280-bit integers using all four cores of a 2.4
Bernstein, D.J., Chen, T.R., Cheng, C.M., Lange, T., Yang, B.Y.   +4 more
openaire   +3 more sources

JKL-ECM: an implementation of ECM using Hessian curves [PDF]

LMS Journal of Computation and Mathematics, 2016
We present JKL-ECM, an implementation of the elliptic curve method of integer factorization which uses certain twisted Hessian curves in a family studied by Jeon, Kim and Lee. This implementation takes advantage of torsion subgroup injection for families of elliptic curves over a quartic number field, in addition to the ‘small parameter’ speedup.
Heer, Henriette, Mcguire, Gary, Robinson, Oisín   +2 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source