From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake Venoms. [PDF]
Toxins (Basel)Australian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade.
Chandrasekara U +5 more
europepmc +7 more sources
X Marks the Clot: Evolutionary and Clinical Implications of Divergences in Procoagulant Australian Elapid Snake Venoms. [PDF]
Toxins (Basel)Australian elapid snakes possess potent procoagulant venoms, capable of inducing severe venom-induced consumption coagulopathy (VICC) in snakebite victims through rapid activation of the coagulation cascade by converting the FVII and prothrombin zymogens
Morecroft H +5 more
europepmc +5 more sources
A Quest for a Universal Plasma-Derived Antivenom Against All Elapid Neurotoxic Snake Venoms [PDF]
Frontiers in Immunology, 2021 This review describes the research aimed at the development of universal antivenom against elapid neurotoxic snake venoms. The antivenoms produced in Thailand in the 1980s were of low potency, especially against the elapid venoms.
Kavi Ratanabanangkoon
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Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis [PDF]
Toxins, 2014 Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms—that of the African cobra, N.
Aisha Munawar +10 more
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Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms. [PDF]
Toxins (Basel)Snakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Khatibi M +6 more
europepmc +2 more sources
PLoS Neglected Tropical Diseases, 2021 Development of a rapid, on-site detection tool for snakebite is highly sought after, owing to its clinically and forensically relevant medicolegal significance.
Sherin Kaul +6 more
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An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms [PDF]
Frontiers in Pharmacology, 2023 Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Yi Wei Chan +3 more
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Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2016 Background The cysteine-rich neurotoxins from elapid venoms are primarily responsible for human and animal envenomation; however, their low concentration in the venom may hamper the production of efficient elapid antivenoms.
Herlinda Clement +5 more
doaj +2 more sources
Identification and structural characterization of a new three-finger toxin hemachatoxin from Hemachatus haemachatus venom. [PDF]
PLoS ONE, 2012 Snake venoms are rich sources of biologically active proteins and polypeptides. Three-finger toxins are non-enzymatic proteins present in elapid (cobras, kraits, mambas and sea snakes) and colubrid venoms.
Vallerinteavide Mavelli Girish +5 more
doaj +11 more sources
A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom. [PDF]
Toxicon XRecent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP ...
Sánchez A +16 more
europepmc +2 more sources