Results 11 to 20 of about 2,691 (214)

Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins [PDF]

Toxins, 2013
Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced.
Timothy Jackson, Kartik Sunagar, Eivind A. B. Undheim, Ivan Koludarov, Angelo Chan, Kate L. Sanders, Syed Imran Ali, Iwan Hendrikx, Nathan Dunstan, Bryan G. Fry   +9 more
doaj   +7 more sources

VenomCap: An exon-capture probe set for the targeted sequencing of snake venom genes. [PDF]

Mol Ecol Resour
Snake venoms are complex mixtures of toxic proteins that hold significant medical, pharmacological and evolutionary interest. To better understand the genetic diversity underlying snake venoms, we developed VenomCap, a novel exon-capture probe set ...
Travers SL, Hutter CR, Austin CC, Donnellan SC, Buehler MD, Ellison CE, Ruane S.   +6 more
europepmc   +4 more sources

Hepatotoxic effect of elapid venom-a rare manifestation: Case report. [PDF]

J Family Med Prim Care
ABSTRACT Snake bite is a neglected tropical disease affecting millions of people across the globe. The highest burden exists in South East Asia and Sub-Saharan Africa. Around 45900 deaths could be attributed to snake bites in India with 25% of these deaths occurring in children between age group of 5–14 years.
Chaudhuri PK, Azam N, Madhur A, Singh J, Kumar R, Prasad A, Sarkar P.   +6 more
europepmc   +4 more sources

Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components

SLAS Discovery
Snake venoms are complex bioactive mixtures designed to paralyse, kill, or digest prey. These venoms are of pharmacological interest due to their ability to modulate molecular targets such as ion channels and receptors with high specificity and potency ...
Arif Arrahman, Haifeng Xu, Muzaffar Ali Khan, Tijmen S. Bos, Julien Slagboom, Guus C van der Velden, Ulrike Nehrdich, Nicholas R. Casewell, Michael K. Richardson, Christian Tudorache, Fernanda C. Cardoso, Jeroen Kool   +11 more
openalex   +4 more sources

Heating up the Blunts: Prothrombin Activation, with Factor Va as an Obligate Cofactor, Is the Dominant Procoagulant Mechanism of Blunt-Nosed Viper Venoms (<i>Macrovipera</i> Species). [PDF]

Toxins (Basel)
Venoms of the Palearctic vipers in the Macrovipera genus cause severe procoagulant clinical effects, yet the precise molecular targets remain incompletely defined. To fill this toxicological knowledge gap, we tested five Macrovipera venoms—M.
Champagne PS, Seneci L, Fry BG.
europepmc   +2 more sources

Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms. [PDF]

Toxins (Basel)
Examination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins.
Kadler R, Morrison B, Yanagihara AA.
europepmc   +2 more sources

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting [PDF]

Toxins, 2017
The cytotoxicity of the venom of 25 species of Old World elapid snake was tested and compared with the morphological and behavioural adaptations of hooding and spitting. We determined that, contrary to previous assumptions, the venoms of spitting species
Nadya Panagides, Timothy N.W. Jackson, Maria P. Ikonomopoulou, Kevin Arbuckle, Rudolf Pretzler, Daryl C. Yang, Syed A. Ali, Ivan Koludarov, James Dobson, Brittany Sanker, Angelique Asselin, Renan C. Santana, Iwan Hendrikx, Harold van der Ploeg, Jeremie Tai-A-Pin, Romilly van den Bergh, Harald M.I. Kerkkamp, Freek J. Vonk, Arno Naude, Morné A. Strydom, Louis Jacobsz, Nathan Dunstan, Marc Jaeger, Wayne C. Hodgson, John Miles, Bryan G. Fry   +25 more
doaj   +8 more sources

Venom gland transcriptomes of two elapid snakes (Bungarus multicinctus and Naja atra) and evolution of toxin genes [PDF]

, 2011
Background Kraits (genus Bungarus) and cobras (genus Naja) are two representative toxic genera of elapids in the old world. Although they are closely related genera and both of their venoms are very toxic, the compositions of their venoms are very ...
Yu Jiang, Yan Li, Wen‐Hui Lee, Xun Xu, Yue Zhang, Ruoping Zhao, Yun Zhang, Wen Wang   +7 more
openalex   +6 more sources

An Appetite for Destruction: Detecting Prey-Selective Binding of α-Neurotoxins in the Venom of Afro-Asian Elapids [PDF]

Toxins, 2020
Prey-selective venoms and toxins have been documented across only a few species of snakes. The lack of research in this area has been due to the absence of suitably flexible testing platforms.
Richard J. Harris, Christina N. Zdenek, David Harrich, Nathaniel Frank, Bryan G. Fry   +4 more
openalex   +3 more sources

An in vitro α-neurotoxin—nAChR binding assay correlates with lethality and in vivo neutralization of a large number of elapid neurotoxic snake venoms from four continents

PLoS Neglected Tropical Diseases, 2020
The aim of this study was to develop an in vitro assay for use in place of in vivo assays of snake venom lethality and antivenom neutralizing potency.
Kritsada Pruksaphon, Nget Hong Tan, Choo Hock Tan, Pavinee Simsiriwong, José Marı́a Gutiérrez, Kavi Ratanabanangkoon   +5 more
openalex   +3 more sources