Results 11 to 20 of about 2,693 (220)

Identification and structural characterization of a new three-finger toxin hemachatoxin from Hemachatus haemachatus venom. [PDF]

PLoS ONE, 2012
Snake venoms are rich sources of biologically active proteins and polypeptides. Three-finger toxins are non-enzymatic proteins present in elapid (cobras, kraits, mambas and sea snakes) and colubrid venoms.
Vallerinteavide Mavelli Girish, Sundramurthy Kumar, Lissa Joseph, Chacko Jobichen, R Manjunatha Kini, J Sivaraman   +5 more
doaj   +11 more sources

Evidence for Resistance to Coagulotoxic Effects of Australian Elapid Snake Venoms by Sympatric Prey (Blue Tongue Skinks) but Not by Predators (Monitor Lizards) [PDF]

Toxins, 2021
Some Australian elapids possess potently procoagulant coagulotoxic venoms which activate the zymogen prothrombin into the functional enzyme thrombin. Although the activity of Australian elapid prothrombin-activators has been heavily investigated with ...
Nicholas J. Youngman, Joshua Llinas, Bryan G. Fry   +2 more
doaj   +2 more sources

An Appetite for Destruction: Detecting Prey-Selective Binding of α-Neurotoxins in the Venom of Afro-Asian Elapids [PDF]

Toxins, 2020
Prey-selective venoms and toxins have been documented across only a few species of snakes. The lack of research in this area has been due to the absence of suitably flexible testing platforms.
Richard J. Harris, Christina N. Zdenek, David Harrich, Nathaniel Frank, Bryan G. Fry   +4 more
doaj   +2 more sources

Activity of two key toxin groups in Australian elapid venoms show a strong correlation to phylogeny but not to diet. [PDF]

BMC Evol Biol, 2020
Tasoulis T, Lee MSY, Ziajko M, Dunstan N, Sumner J, Isbister GK.   +5 more
europepmc   +3 more sources

A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom [PDF]

Toxicon: X
Recent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP ...
Andrés Sánchez, Gina Durán, Maykel Cerdas, Jairo Gutiérrez, Álvaro Segura, María Herrera, Mariángela Vargas, Adriana Sánchez, Paola Sánchez, Gabriela Solano, Mauren Villalta, Edwin Moscoso, Deibid Umaña, Mauricio Arguedas, Aarón Gómez, José María Gutiérrez, Guillermo León   +16 more
doaj   +2 more sources

Hepatotoxic effect of elapid venom-a rare manifestation: Case report. [PDF]

J Family Med Prim Care
ABSTRACT Snake bite is a neglected tropical disease affecting millions of people across the globe. The highest burden exists in South East Asia and Sub-Saharan Africa. Around 45900 deaths could be attributed to snake bites in India with 25% of these deaths occurring in children between age group of 5–14 years.
Chaudhuri PK, Azam N, Madhur A, Singh J, Kumar R, Prasad A, Sarkar P.   +6 more
europepmc   +4 more sources

Heating up the Blunts: Prothrombin Activation, with Factor Va as an Obligate Cofactor, Is the Dominant Procoagulant Mechanism of Blunt-Nosed Viper Venoms (Macrovipera Species) [PDF]

Toxins
Venoms of the Palearctic vipers in the Macrovipera genus cause severe procoagulant clinical effects, yet the precise molecular targets remain incompletely defined. To fill this toxicological knowledge gap, we tested five Macrovipera venoms—M.
Patrick S. Champagne, Lorenzo Seneci, Bryan G. Fry   +2 more
doaj   +2 more sources

An in vitro α-neurotoxin-nAChR binding assay correlates with lethality and in vivo neutralization of a large number of elapid neurotoxic snake venoms from four continents.

PLoS Neglected Tropical Diseases, 2020
The aim of this study was to develop an in vitro assay for use in place of in vivo assays of snake venom lethality and antivenom neutralizing potency.
Kritsada Pruksaphon, Kae Yi Tan, Choo Hock Tan, Pavinee Simsiriwong, José María Gutiérrez, Kavi Ratanabanangkoon   +5 more
doaj   +3 more sources

Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms [PDF]

Toxins
Examination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins.
Raechel Kadler, Breanna Morrison, Angel Anne Yanagihara   +2 more
doaj   +2 more sources

Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components

SLAS Discovery
Snake venoms are complex bioactive mixtures designed to paralyse, kill, or digest prey. These venoms are of pharmacological interest due to their ability to modulate molecular targets such as ion channels and receptors with high specificity and potency ...
Arif Arrahman, Haifeng Xu, Muzaffar A. Khan, Tijmen S. Bos, Julien Slagboom, Guus C. van der Velden, Ulrike Nehrdich, Nicholas R. Casewell, Michael K. Richardson, Christian Tudorache, Fernanda C. Cardoso, Jeroen Kool   +11 more
doaj   +3 more sources