The Venom Proteome of the Ecologically Divergent Australian Elapid, Southern Death Adder <i>Acanthophis antarcticus</i>. [PDF]
Toxins (Basel)Tasoulis T +7 more
europepmc +3 more sources
Electrical Cell Impedance Sensing (ECIS): Feasibility of a Novel In Vitro Approach to Studying Venom Toxicity and Potential Therapeutics [PDF]
ToxinsSnakebite envenoming is often discussed in terms of lethality and limb loss, but local tissue injury and coagulotoxic effects of venom are significantly more common acute manifestations of snakebite envenoming (SBE).
Abhinandan Choudhury +7 more
doaj +2 more sources
Two pathways for venom toxin entry consequent to injection of an Australian elapid snake venom [PDF]
Scientific Reports, 2019 AbstractHere we test and refute the hypothesis that venom toxins from an Australian elapid, the Eastern Brown snake (Pseudonaja textilis, PTx), solely require lymphatic transport to enter the circulation. Studies were made using anaesthetised non-recovery rats in which a marker dye (India ink) or highly potent PTx venom was injected into the hind paw ...
Dirk van Helden +3 more
openalex +3 more sources
VenomCap: An exon-capture probe set for the targeted sequencing of snake venom genes. [PDF]
Mol Ecol ResourSnake venoms are complex mixtures of toxic proteins that hold significant medical, pharmacological and evolutionary interest. To better understand the genetic diversity underlying snake venoms, we developed VenomCap, a novel exon-capture probe set ...
Travers SL +6 more
europepmc +3 more sources
Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis
PLOS Neglected Tropical Diseases, 2018 Envenomings by snakebites constitute a serious and challenging global health issue. The mainstay in the therapy of snakebite envenomings is the parenteral administration of animal-derived antivenoms. Significantly, antivenoms are only partially effective in the control of local tissue damage. A novel approach to mitigate the progression of local tissue
Jeffrey O’Brien +3 more
openalex +7 more sources
Elapid venom toxins: multiple recruitments of ancient scaffolds [PDF]
European Journal of Biochemistry, 1999 Nigroxins A and B, two myotoxic phospholipases A2 (PLA2s) from the venom of the American elapid Micrurus nigrocinctus, belong to a new PLA2 subclass. Their primary structures were established and compared with those of PLA2s that have already been studied with respect to myotoxic activity.
Alberto Alape‐Girón +7 more
openalex +6 more sources
Pro‐inflammatory activities in elapid snake venoms [PDF]
Toxicon, 1994 Snake venoms from the genera Micrurus (M. ibiboboca and M. spixii) and Naja (N. naja, N. melanoleuca and N. nigricollis) were analysed, using biological and immunochemical methods, to detect pro‐inflammatory activities, cobra venom factor (COF), proteolytic enzymes, thrombin‐like substances, haemorrhagic and oedema‐producing substances.
Denise V. Tambourgi +5 more
openalex +4 more sources
The Unusual Metalloprotease-Rich Venom Proteome of the Australian Elapid Snake Hoplocephalus stephensii [PDF]
Toxins, 2022 The Australasian region is home to the most diverse elapid snake radiation on the planet (Hydrophiinae). Many of these snakes have evolved into unique ecomorphs compared to elapids on other continents; however, their venom compositions are poorly known.
Theo Tasoulis +5 more
openalex +5 more sources
Venom ‘spitting’ during handling in an Australian elapid snake
Herpetofauna, 2005 Nick Clemann, Haley Butler
openalex +3 more sources
Three-finger toxins, a deadly weapon of elapid venom – Milestones of discovery
Toxicon, 2012 Three-finger toxins (TFTs) are the main venom components of snakes from Elapidae family. Amino acid sequences of more than five hundreds TFTs are determined; these toxins form one of the largest protein families present in snake venoms. The first TFT α-bungarotoxin was isolated almost half a century ago and so far it remains a valuable tool in the ...
Yuri N. Utkin
openalex +4 more sources