Results 31 to 40 of about 2,691 (214)
Three-finger toxins, a deadly weapon of elapid venom – Milestones of discovery
Toxicon, 2012 Three-finger toxins (TFTs) are the main venom components of snakes from Elapidae family. Amino acid sequences of more than five hundreds TFTs are determined; these toxins form one of the largest protein families present in snake venoms. The first TFT α-bungarotoxin was isolated almost half a century ago and so far it remains a valuable tool in the ...
Yuri N. Utkin
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Comparative Analysis of Prothrombin Activators from the Venom of Australian Elapids [PDF]
Molecular Biology and Evolution, 2005 A key component of the venom of many Australian snakes belonging to the elapid family is a toxin that is structurally and functionally similar to that of the mammalian prothrombinase complex. In mammals, this complex is responsible for the cleavage of prothrombin to thrombin and is composed of factor Xa in association with its cofactors calcium ...
Liam St. Pierre +6 more
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Elapid venom toxins: multiple recruitments of ancient scaffolds [PDF]
European Journal of Biochemistry, 1999 Nigroxins A and B, two myotoxic phospholipases A2 (PLA2s) from the venom of the American elapid Micrurus nigrocinctus, belong to a new PLA2 subclass. Their primary structures were established and compared with those of PLA2s that have already been studied with respect to myotoxic activity.
Alberto Alape‐Girón +7 more
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A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia. [PDF]
PLoS Neglected Tropical Diseases, 2016 Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease.
Kavi Ratanabanangkoon +8 more
doaj +1 more source
Toxins, 2023 The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel +8 more
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The Unusual Metalloprotease-Rich Venom Proteome of the Australian Elapid Snake Hoplocephalus stephensii [PDF]
Toxins, 2022 The Australasian region is home to the most diverse elapid snake radiation on the planet (Hydrophiinae). Many of these snakes have evolved into unique ecomorphs compared to elapids on other continents; however, their venom compositions are poorly known.
Theo Tasoulis +5 more
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Neurotoxic, cytotoxic and cardiovascular effects of some Australasian elapid venoms
, 2017 A range of toxic components found in Australasian elapid venoms have been postulated to account for the clinical outcomes of envenoming. Depending on the species of snake, these outcomes may include neurotoxicity with flaccid paralysis, coagulopathy with spontaneous systemic hemorrhage, sudden cardiovascular collapse, and myotoxicity with skeletal ...
Janeyuth Chaisakul
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Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits
Toxins, 2023 Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
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Two pathways for venom toxin entry consequent to injection of an Australian elapid snake venom [PDF]
Scientific Reports, 2019 AbstractHere we test and refute the hypothesis that venom toxins from an Australian elapid, the Eastern Brown snake (Pseudonaja textilis, PTx), solely require lymphatic transport to enter the circulation. Studies were made using anaesthetised non-recovery rats in which a marker dye (India ink) or highly potent PTx venom was injected into the hind paw ...
Dirk van Helden +3 more
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Toxins, 2022 Envenomation by elapid snakes primarily results in neurotoxic symptoms and, consequently, are the primary focus of therapeutic research concerning such venoms. However, mounting evidence suggests these venoms can additionally cause coagulopathic symptoms,
Arif Arrahman +7 more
doaj +1 more source