Results 31 to 40 of about 2,693 (220)

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

open access: yes, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J.   +3 more
core   +12 more sources

Structure‐activity studies of homologues of short chain neurotoxins from Elapid snake venoms [PDF]

open access: bronzeBritish Journal of Pharmacology, 1984
Three neurotoxin homologues (CM10 and CM12 from Naja haje annulifera and S5C10 from Dendroaspis jamesoni kaimosae) and two short neurotoxins (CM14 from Naja haje annulifera and erabutoxin b from Laticauda semifasciata)were examined by circular dichroism (c.d.) and tested for neuromuscular activity on chick biventer cervicis nerve‐muscle preparations ...
Alan L. Harvey   +3 more
openalex   +4 more sources

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

open access: yesToxins, 2023
The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel   +8 more
doaj   +1 more source

Neurotoxic, cytotoxic and cardiovascular effects of some Australasian elapid venoms

open access: green, 2017
A range of toxic components found in Australasian elapid venoms have been postulated to account for the clinical outcomes of envenoming. Depending on the species of snake, these outcomes may include neurotoxicity with flaccid paralysis, coagulopathy with spontaneous systemic hemorrhage, sudden cardiovascular collapse, and myotoxicity with skeletal ...
Janeyuth Chaisakul
openalex   +2 more sources

Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits

open access: yesToxins, 2023
Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
doaj   +1 more source

A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib

open access: yesToxins, 2022
Envenomation by elapid snakes primarily results in neurotoxic symptoms and, consequently, are the primary focus of therapeutic research concerning such venoms. However, mounting evidence suggests these venoms can additionally cause coagulopathic symptoms,
Arif Arrahman   +7 more
doaj   +1 more source

Comparative Analysis of Prothrombin Activators from the Venom of Australian Elapids [PDF]

open access: bronzeMolecular Biology and Evolution, 2005
A key component of the venom of many Australian snakes belonging to the elapid family is a toxin that is structurally and functionally similar to that of the mammalian prothrombinase complex. In mammals, this complex is responsible for the cleavage of prothrombin to thrombin and is composed of factor Xa in association with its cofactors calcium ...
Liam St. Pierre   +6 more
openalex   +4 more sources

Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes

open access: yesScientific African, 2023
Envenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes from the viperidae (E.
Fatima Amin Adamude   +5 more
doaj   +1 more source

Cross neutralization of Afro-Asian cobra and Asian krait venoms by a Thai polyvalent snake antivenom (Neuro Polyvalent Snake Antivenom). [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2012
BACKGROUND: Snake envenomation is a serious public health threat in the rural areas of Asian and African countries. To date, the only proven treatment for snake envenomation is antivenom therapy.
Poh Kuan Leong   +5 more
doaj   +1 more source

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