Comparative venom toxin analyses of Nigerian viperidae and elapidae snakes
Scientific African, 2023 Envenoming by snakebite is a serious health problem that maims and kills a large number of people, primarily in rural areas of developing African countries. The first comparative venom proteomic analyses of four snakes from the viperidae (E.
Fatima Amin Adamude +5 more
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Structure‐activity studies of homologues of short chain neurotoxins from Elapid snake venoms [PDF]
British Journal of Pharmacology, 1984 Three neurotoxin homologues (CM10 and CM12 from Naja haje annulifera and S5C10 from Dendroaspis jamesoni kaimosae) and two short neurotoxins (CM14 from Naja haje annulifera and erabutoxin b from Laticauda semifasciata)were examined by circular dichroism (c.d.) and tested for neuromuscular activity on chick biventer cervicis nerve‐muscle preparations ...
Alan L. Harvey +3 more
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Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]
, 2015 Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J. +3 more
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Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis
PLOS Neglected Tropical Diseases, 2018 Envenomings by snakebites constitute a serious and challenging global health issue. The mainstay in the therapy of snakebite envenomings is the parenteral administration of animal-derived antivenoms. Significantly, antivenoms are only partially effective in the control of local tissue damage. A novel approach to mitigate the progression of local tissue
Jeffrey O’Brien +3 more
openalex +7 more sources
Toxins, 2021 Some Australian elapids possess potently procoagulant coagulotoxic venoms which activate the zymogen prothrombin into the functional enzyme thrombin. Although the activity of Australian elapid prothrombin-activators has been heavily investigated with ...
Nicholas J. Youngman +2 more
doaj +1 more source
Cross neutralization of Afro-Asian cobra and Asian krait venoms by a Thai polyvalent snake antivenom (Neuro Polyvalent Snake Antivenom). [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Snake envenomation is a serious public health threat in the rural areas of Asian and African countries. To date, the only proven treatment for snake envenomation is antivenom therapy.
Poh Kuan Leong +5 more
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Identification of presynaptic neurotoxin complexes in the venoms of three Australian copperheads (Austrelaps spp.) and the efficacy of tiger snake antivenom to prevent or reverse neurotoxicity [PDF]
, 2011 The venom of the Australian lowlands copperhead, Austrelaps superbus, produces significant and potentially lethal neurotoxic paralysis in cases of clinical envenomation. However, little is known about the neurotoxic components within this venom or venoms
Marcon, F, Nicholson, GM
core +1 more source
Investigating Toxin Diversity and Abundance in Snake Venom Proteomes
Frontiers in Pharmacology, 2022 Understanding snake venom proteomes is becoming increasingly important to understand snake venom biology, evolution and especially clinical effects of venoms and approaches to antivenom development.
Theo Tasoulis +2 more
doaj +1 more source
Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons. [PDF]
, 2016 BACKGROUND Snake venoms contain many proteinaceous toxins that can cause severe pathology and mortality in snakebite victims. Interestingly, mRNA encoding such toxins can be recovered directly from venom, although yields are low and quality is unknown ...
Logan, Rhiannon
core +1 more source
Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation
Toxins, 2016 While decades of research have focused on snake venom proteins, far less attention has been paid to small organic venom constituents. Using mostly pooled samples, we surveyed 31 venoms (six elapid, six viperid, and 19 crotalid) for spermine, spermidine ...
Steven D. Aird +3 more
doaj +1 more source