Results 11 to 20 of about 8,091 (214)

Dual Fatty Acid Elongase Complex Interactions in Arabidopsis. [PDF]

PLoS ONE, 2016
Very long chain fatty acids (VLCFAs) are involved in plant development and particularly in several cellular processes such as membrane trafficking, cell division and cell differentiation.
Céline Morineau, Lionel Gissot, Yannick Bellec, Kian Hematy, Frédérique Tellier, Charlotte Renne, Richard Haslam, Frédéric Beaudoin, Johnathan Napier, Jean-Denis Faure   +9 more
doaj   +8 more sources

Tackling functional redundancy of Arabidopsis fatty acid elongase complexes [PDF]

Frontiers in Plant Science, 2023
Very-long-chain fatty acids (VLCFA) are precursors for various lipids playing important physiological and structural roles in plants. Throughout plant tissues, VLCFA are present in multiple lipid classes essential for membrane homeostasis, and also ...
Marguerite Batsale, Marie Alonso, Marie Alonso, Stéphanie Pascal, Didier Thoraval, Richard P. Haslam, Frédéric Beaudoin, Frédéric Domergue, Jérôme Joubès   +8 more
doaj   +6 more sources

Combinatorial Effects of Fatty Acid Elongase Enzymes on Nervonic Acid Production in Camelina sativa. [PDF]

PLoS ONE, 2015
Very long chain fatty acids (VLCFAs) with chain lengths of 20 carbons and longer provide feedstocks for various applications; therefore, improvement of VLCFA contents in seeds has become an important goal for oilseed enhancement.
Dongxin Huai, Yuanyuan Zhang, Chunyu Zhang, Edgar B Cahoon, Yongming Zhou   +4 more
doaj   +3 more sources

Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases [PDF]

Journal of Lipid Research, 2005
Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 = Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult ...
Yun Wang, Daniela Botolin, Barbara Christian, Julia Busik, Jinghua Xu, Donald B. Jump   +5 more
doaj   +3 more sources

Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity [PDF]

Journal of Lipid Research, 2006
Fatty acid elongases and desaturases play an important role in hepatic and whole body lipid composition. We examined the role that key transcription factors played in the control of hepatic elongase and desaturase expression.
Yun Wang, Daniela Botolin, Jinghua Xu, Barbara Christian, Ernestine Mitchell, Bolleddula Jayaprakasam, Muraleedharan Nair, Jeffery M. Peters, Julia Busik, L. Karl Olson, Donald B. Jump   +10 more
doaj   +3 more sources

Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis

Journal of Lipid Research, 2004
In algae, the biosynthesis of docosahexaenoic acid (22:6ω3; DHA) proceeds via the elongation of eicosapentaenoic acid (20:5ω3; EPA) to 22:5ω3, which is required as a substrate for the final Δ4 desaturation. To isolate the elongase specific for this step,
Astrid Meyer, Helene Kirsch, Frédéric Domergue, Amine Abbadi, Petra Sperling, Jörg Bauer, Petra Cirpus, Thorsten K. Zank, Hervé Moreau, Thomas J. Roscoe, Ulrich Zähringer, Ernst Heinz   +11 more
doaj   +3 more sources

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7 [PDF]

FEBS Letters, 2011
Very long-chain fatty acids (VLCFAs) have a variety of physiological functions and are related to numerous disorders. The key step of VLCFA elongation is catalyzed by members of the elongase family, ELOVLs. Mammals have seven ELOVLs (ELOVL1-7), yet none of them has been purified and analyzed.
Naganuma, Tatsuro, Sato, Yuichiro, Sassa, Takayuki, Ohno, Yusuke, Kihara, Akio   +4 more
openaire   +4 more sources

Dual Fatty Acid Elongase Complex Interactions in Arabidopsis

, 2015
Very long chain fatty acids (VLCFAs) are required for the synthesis of triacylglycerols, waxes, phospholipids and sphingolipids. Fatty acyl chain length is essential for plant development in particular for membrane trafficking during cell division and cell differentiation [1–3].
Morineau, Céline, Gissot, Liojnel, Bellec, Yannick, Tellier, Frédérique, Hematy, Kian, Beaudoin, Frédéric, Haslam, Richard, Faure, Jean-Denis   +7 more
core   +3 more sources

The structural basis of fatty acid elongation by the ELOVL elongases [PDF]

Nature Structural & Molecular Biology, 2020
Abstract Very long chain fatty acids (VLCFAs) are essential building blocks for synthesis of the ceramides and sphingolipids required for nerve, skin and retina function and 3-keto acyl-CoA synthases (ELOVL elongases) perform the first step in the FA elongation cycle.
Nie, L, Pascoa, TC, Pike, ACW, Bushell, SR, Quigley, A, Ruda, GF, Chu, A, Cole, V, Speedman, D, Moreira, T, Shrestha, L, Mukhopadhyay, SMM, Burgess-Brown, NA, Love, JD, Brennan, PE, Carpenter, EP   +15 more
openaire   +6 more sources

Fatty acid elongase (FAE) systems: An investigation of genetic redundancy

, 2018
Biosynthesis of very long chain fatty acids (VLCFAs) is an integral process for plants, animals & yeast. VLCFAs serve in a variety of biological processes (e.g. protein trafficking, membrane stabilization, precursors for lipid second messengers) and in plants, are components of cuticular waxes, suberin, sphingolipids, phospholipids, seed oils, and GPI ...
Campbell, Alexis
openaire   +4 more sources