Results 21 to 30 of about 8,658 (206)
The structural basis of fatty acid elongation by the ELOVL elongases [PDF]
Nature Structural & Molecular Biology, 2020 Abstract Very long chain fatty acids (VLCFAs) are essential building blocks for synthesis of the ceramides and sphingolipids required for nerve, skin and retina function and 3-keto acyl-CoA synthases (ELOVL elongases) perform the first step in the FA elongation cycle.
Nie, L +15 more
openaire +4 more sources
Elongase And Uses Thereof (Patent US 8119861 B2) [PDF]
, 2012 The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a Δ8-desaturase and a Δ5-desaturase enzyme.
Sayanova, O. V. +2 more
core +3 more sources
Journal of Lipid Research, 2006 The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction.
Ana Anzulovich +5 more
doaj +1 more source
Functional Characterization of the Chicken Fatty Acid Elongases [PDF]
The Journal of Nutrition, 2013 The health benefits of the (n-3) PUFA, EPA, and DHA have created a demand for fish and fish oil, the main sources of these PUFA. Production animals, such as poultry, are potential alternate and sustainable sources of EPA and DHA, provided these fatty acids can be synthesized from plant-derived α-linolenic acid [ALA, 18:3(n-3)].
Gregory, M. +3 more
openaire +3 more sources
Polysaturated Fatty Acid (pufa) Elongase From Caenorhabditis Elegans (Patent WO 2000/055330 A1) [PDF]
, 2000 A isolated polypeptide comprising a functional long chain polyunsaturated fatty acid (PUFA ...
Napier, J. A.
core +3 more sources
Frontiers in Marine Science, 2020 This study was designed to evaluate the effect of dietary lipid levels on the mRNA transcripts of lipid metabolic regulatory genes. Nine combinations of experimental diets containing graded lipid (80, 100, and 120 g/kg) and protein (450, 500, and 550 g ...
Ishfaq Nazir Mir +4 more
doaj +1 more source
Journal of Lipid Research, 2013 Functional characterization of the rat elongases, Elovl5 and Elovl2, has identified that Elovl2 is crucial for omega-3 docosahexaenoic acid (DHA) (22:6n-3) synthesis.
Melissa K. Gregory +2 more
doaj +1 more source
Lifestyle Genomics, 2020 Background: At present, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids.
Michael A. Schmidt +4 more
doaj +1 more source
Combinatorial Effects of Fatty Acid Elongase Enzymes on Nervonic Acid Production in Camelina sativa. [PDF]
PLoS ONE, 2015 Very long chain fatty acids (VLCFAs) with chain lengths of 20 carbons and longer provide feedstocks for various applications; therefore, improvement of VLCFA contents in seeds has become an important goal for oilseed enhancement.
Dongxin Huai +4 more
doaj +1 more source
Elongase Gene And Production Of Delta9-polyunsaturated Fatty Acids (Patent US 2005/0089981 A1) [PDF]
, 2005 This invention relates to a new elongase gene having the sequence SEQ ID NO: 1 or its derivatives, to a gene construct comprising this sequence or its derivatives and to its use.
Napier, J. A. +3 more
core +3 more sources