Results 21 to 30 of about 8,091 (214)
ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer [PDF]
Cancer Research, 2021 Abstract The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation of novel AR targeting therapies, outcomes for metastatic disease remain dismal. There is an urgent need to better understand androgen-regulated cellular processes to more effectively ...
Margaret M. Centenera +32 more
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Fatty Acid Synthesis by Elongases in Trypanosomes [PDF]
Cell, 2006 All eukaryotic and prokaryotic organisms are thought to synthesize fatty acids using a type I or type II synthase. In addition, eukaryotes extend pre-existing long chain fatty acids using microsomal elongases (ELOs). We have found that Trypanosoma brucei, a eukaryotic human parasite that causes sleeping sickness, uses three elongases instead of type I ...
Lee, Soo Hee +3 more
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Functional Characterization of the Chicken Fatty Acid Elongases [PDF]
The Journal of Nutrition, 2013 The health benefits of the (n-3) PUFA, EPA, and DHA have created a demand for fish and fish oil, the main sources of these PUFA. Production animals, such as poultry, are potential alternate and sustainable sources of EPA and DHA, provided these fatty acids can be synthesized from plant-derived α-linolenic acid [ALA, 18:3(n-3)].
Gregory, M. +3 more
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Fatty acid elongase is required for shoot development in rice [PDF]
The Plant Journal, 2011 SummaryOrganisms are covered extracellularly with cuticular waxes that consist of various fatty acids. In higher plants, extracellular waxes act as indispensable barriers to protect the plants from physical and biological stresses such as drought and pathogen attacks.
Yukihiro, Ito +7 more
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Targeted lipidomics reveals a novel role for glucosylceramides in glucose response
Journal of Lipid Research, 2023 The addition of excess glucose to the diet drives a coordinated response of lipid metabolism pathways to tune the membrane composition to the altered diet.
Mark A. Xatse +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used stable
Johanna von Gerichten +8 more
doaj +1 more source
Apocryphal FADS2 activity promotes fatty acid diversification in cancer
Cell Reports, 2021 Summary: Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation.
Reuben S.E. Young +13 more
doaj +1 more source
Cryptosporidium parvum Long-Chain Fatty Acid Elongase [PDF]
Eukaryotic Cell, 2007 ABSTRACT We report the presence of a new fatty acyl coenzyme A (acyl-CoA) elongation system in Cryptosporidium and the functional characterization of the key enzyme, a single long-chain fatty acid elongase (LCE), in this parasite.
Jason M, Fritzler +2 more
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Brain Sciences, 2022 One line of research on the possible ways of inhibiting the growth of glioblastoma multiforme (GBM), a brain tumor with a very poor prognosis, is the analysis of its metabolism, such as fatty acid synthesis by desaturases and elongases.
Jan Korbecki +7 more
doaj +1 more source
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma [PDF]
Blood Advances, 2021 AbstractResistance to the proteasome inhibitor bortezomib (BTZ) represents a major obstacle in the treatment of multiple myeloma (MM). The contribution of lipid metabolism in the resistance of MM cells to BTZ is mostly unknown. Here we report that levels of fatty acid elongase 6 (ELOVL6) were lower in MM cells from BTZ-nonresponsive vs BTZ-responsive ...
Brittany C. Lipchick +12 more
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