Results 41 to 50 of about 8,091 (214)

Regulation of Rat Hepatic Elongase and Desaturase Expression

The FASEB Journal, 2006
Hepatic fatty acid elongases (Elovl‐1, ‐2, ‐5 & ‐6) and desaturases [delta‐5 (D5D), delta‐6 (D6D), delta‐9 (D9D)] play an important role in hepatic and whole body lipid composition. In contrast to the desaturases, little is known about the control of elongase expression.
Yun Wang, Daniela Botolin, Jinghua Xu, Barbara Christian, Donald B Jump   +4 more
openaire   +1 more source

Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells

Frontiers in Immunology, 2018
Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised.
Charlene M. Sibbons, Charlene M. Sibbons, Nicola A. Irvine, J. Eduardo Pérez-Mojica, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge   +7 more
doaj   +1 more source

Zinc Deficiency, Plasma Fatty Acid Profile and Desaturase Activities in Hemodialysis Patients: Is Supplementation Necessary?

Frontiers in Nutrition, 2021
Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes.
Marija Takic, Milica Zekovic, Brankica Terzic, Brankica Terzic, Aleksandar Stojsavljevic, Mirjana Mijuskovic, Mirjana Mijuskovic, Slavica Radjen, Slavica Radjen, Danijela Ristic-Medic, Danijela Ristic-Medic   +10 more
doaj   +1 more source

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6

Cell Reports, 2015
Although many transcriptional pathways regulating BAT have been identified, the role of lipid biosynthetic enzymes in thermogenesis has been less investigated.
Chong Yew Tan, Samuel Virtue, Guillaume Bidault, Martin Dale, Rachel Hagen, Julian L. Griffin, Antonio Vidal-Puig   +6 more
doaj   +1 more source

Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation. [PDF]

PLoS ONE, 2013
The lipid lamellae in the stratum corneum is important for the epidermal permeability barrier. The lipid lamellae component ceramide (CER), comprising an ultra long-chain (ULC) fatty acid (FA) of ≥26 carbons (ULC CER), plays an essential role in barrier ...
Yukiko Mizutani, Hui Sun, Yusuke Ohno, Takayuki Sassa, Takeshi Wakashima, Mari Obara, Kohei Yuyama, Akio Kihara, Yasuyuki Igarashi   +8 more
doaj   +1 more source

Functional characterisation of a Fads2 fatty acyl desaturase with delta6/delta8 activity and an Elovl5 with C16, C18 and C20 elongase activity in the anadromous teleost meagre (Argyrosomus regius) [PDF]

, 2013
The meagre, Argyrosomus regius, is a carnivorous fish with great potential to diversify finfish aquaculture in the Mediterranean. However, currently nothing is known about their essential fatty acid requirements.
Hontoria, Francisco, Navarro, Juan Carlos, Monroig, Oscar, Tocher, Douglas R, Tocher, Douglas R.   +4 more
core   +1 more source

Triangle of U Fatty Acid Elongase (FAE1) Phylogenetic Tree

, 2022
Alignment file and Newick tree for Fatty Acid Elongase (FAE1) orthologs among the Triangle of U species. To investigate orthologs among the Triangle of U species, phylogenetic trees were constructed for three agriculturally important genes: Flowering ...
Mia Swain (12552355)
core   +1 more source

An evolutionary perspective on Elovl5 fatty acid elongase: comparison of Northern pike and duplicated paralogs from Atlantic salmon [PDF]

, 2013
BACKGROUND The ability to produce physiologically critical LC-PUFA from dietary fatty acids differs greatly among teleost species, and is dependent on the possession and expression of fatty acyl desaturase and elongase genes. Atlantic salmon, as a result
John B Taggart, Tocher, Douglas R, Taggart, John, Michael J Leaver, Leaver, Michael, Greta Carmona-Antoñanzas, Carmona-Antonanzas, Greta, Douglas R Tocher   +7 more
core   +1 more source

The repertoire of desaturases and elongases reveals fatty acid variations in 56 eukaryotic genomes [PDF]

Journal of Lipid Research, 2008
The repertoire of biosynthetic enzymes found in an organism is an important clue for elucidating the chemical structural variations of various compounds. In the case of fatty acids, it is essential to examine key enzymes that are desaturases and elongases, whose combination determine the range of fatty acid structures. We systematically investigated 56
Kosuke Hashimoto, Akiyasu C. Yoshizawa, Shujiro Okuda, Keiichi Kuma, Susumu Goto, Minoru Kanehisa   +5 more
openaire   +3 more sources

Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species

Open Biology, 2023
Previous data revealed the unexpected presence of genes encoding for long-chain polyunsaturated fatty acid (LC-PUFA) biosynthetic enzymes in transcriptomes from freshwater gammarids but not in marine species, even though closely related species were ...
Alberto Ribes-Navarro, Naoki Kabeya, L. Filipe C. Castro, André Gomes-dos-Santos, Miguel M. Fonseca, Hilke Alberts-Hubatsch, Francisco Hontoria, Juan C. Navarro, Óscar Monroig   +8 more
doaj   +1 more source