Results 61 to 70 of about 8,091 (214)

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Elongase Gene And Production Of Delta9-polyunsaturated Fatty Acids (Patent US 7601889 B2) [PDF]

, 2009
This invention relates to a new elongase gene having the sequence SEQ ID NO: 1 or its derivatives, to a gene construct comprising this sequence or its derivatives and to its use.
Napier, J. A., Larzarus C. M., Qi, B., Lerchl, J.   +3 more
core  

The seed‐specific transcription factor DPBF2 modulates the fatty acid composition in seeds

Plant Direct, 2022
Triacylglycerol (TAG), an ester derived from glycerol and three fatty acids (FAs), is synthesized during seed development and controlled by transcriptional regulation.
Inyoung Kim, Kyeong‐Ryeol Lee, Mid‐Eum Park, Hyun Uk Kim   +3 more
doaj   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Stearoyl-CoA Desaturase Activity Is Elevated by the Suppression of Its Degradation by Clofibric Acid in the Liver of Rats

Journal of Pharmacological Sciences, 2007
A mechanism by which fibrates control stearoyl-CoA desaturase (SCD) in the liver was studied. Treatment of rats with 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) or feeding of a fat-free diet markedly elevated hepatic activity of SCD. Both
Tomoaki Toyama, Naomi Kudo, Atsushi Mitsumoto, Yasuhide Hibino, Tadashi Tsuda, Yoichi Kawashima   +5 more
doaj   +1 more source

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

Medical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan, Andrew Hemphill, S. H. P. Parakrama Karunaratne, Arunasalam Naguleswaran, Isabel Roditi, Sinnathamby N. Surendran, Ranjan Ramasamy   +6 more
wiley   +1 more source

Functional Characterization of the Arabidopsis β-Ketoacyl-Coenzyme A Reductase Candidates of the Fatty Acid Elongase

, 2009
In plants, very-long-chain fatty acids (VLCFAs; \u3e18 carbon) are precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin. VLCFAs are synthesized by a multiprotein membrane-bound fatty acid elongation system that catalyzes four ...
Haslam, Richard P., Napier, Johnathan A., Beaudoin, Frédéric, Kunst, L., Johnathan A. Napier, Kunst, Ljerka, Huanquan Zheng, Richard P. Haslam, Beaudoin, F., Fengling Li, Zheng, Huanquan, Frédéric Beaudoin, Wu, Xianzhong, Haslam, R. P., Ljerka Kunst, Li, Fengling, Markham, J. E., Wu, X., Li, F., Markham, Jennifer E., Markham, Jonathan E., Napier, J. A., Zheng, H., Xianzhong Wu, Jennifer E. Markham   +24 more
core   +1 more source

Zebrafish cDNA encoding multifunctional fatty acid elongase involved in production of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids [PDF]

, 2004
Enzymes that increase the chain length of fatty acids are essential for biosynthesis of highly unsaturated fatty acids. The gLELO gene encodes a protein involved in the elongation of polyunsaturated fatty acids in the fungus Mortierella alpina.
Teale, Alan J, Dickson, Cathryn, Tocher, Douglas R, Agaba, Morris K, Dick, James R   +4 more
core   +1 more source

The catadromous teleost Anguilla japonica has a complete enzymatic repertoire for the biosynthesis of docosahexaenoic acid from alpha-linolenic acid: Cloning and functional characterization of an Elovl2 elongase [PDF]

, 2020
The Japanese eel Anguilla japonica is a catadromous fish species with considerable farming scale. Previous studies showed that dietary α-linolenic acid (18:3n-3) and linoleic acid (18:2n-6) satisfied essential fatty acid requirements in eel, which ...
You, Cuihong, Monroig, Oscar, Tocher, Douglas R, Tocher, Douglas R., Xu, Wenju, Wang, Shuqi, Li, Yuanyou, Zhang, Yueling   +7 more
core   +1 more source

Rat heart cannot synthesize docosahexaenoic acid from circulating α-linolenic acid because it lacks elongase-2

Journal of Lipid Research, 2008
The extent to which the heart can convert α-linolenic acid (α-LNA, 18:3n-3) to longer chain n-3 PUFAs is not known. Conversion rates can be measured in vivo using radiolabeled α-LNA and a kinetic fatty acid model.
Miki Igarashi, Kaizong Ma, Lisa Chang, Jane M. Bell, Stanley I. Rapoport   +4 more
doaj   +1 more source