Results 71 to 80 of about 8,658 (206)

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs

Journal of Lipid Research, 2002
The mammalian enzyme involved in the final elongation of de novo fatty acid biosynthesis following the building of fatty acids to 16 carbons by fatty acid synthase has yet to be identified.
Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Tomohiro Yoshikawa, Michiyo Amemiya-Kudo, Alyssa H. Hasty, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Jun-ichi Osuga, Akimitsu Takahashi, Shigeru Yato, Hirohito Sone, Shun Ishibashi, Nobuhiro Yamada   +15 more
doaj   +1 more source

Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. [PDF]

PLoS ONE, 2011
We identified three S. cerevisiae lipid elongase null mutants (elo1Δ, elo2Δ, and elo3Δ) that enhance the toxicity of alpha-synuclein (α-syn). These elongases function in the endoplasmic reticulum (ER) to catalyze the elongation of medium chain fatty ...
Yong Joo Lee, Shaoxiao Wang, Sunny R Slone, Talene A Yacoubian, Stephan N Witt   +4 more
doaj   +1 more source

Acute exercise‐induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice

Experimental Physiology, Volume 111, Issue 10, Page 4457-4497, 1 October 2026.
Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans, the effects of acute exercise on FAHFA levels remain ...
Marko Mitrovic, Olga Horakova, Martin Riecan, Veronika Kleinova, Tomas Cajka, Lenka Rossmeislova, Ondrej Kuda, Martin Rossmeisl   +7 more
wiley   +1 more source

PTPLA interacts with the elongase complex subunits in the ER.

, 2016
(A-C) Subcellular distribution in N.benthamiana epidermal cells of 35S:mcherry-PTPLA (A) and pPAS2:GFP-PAS2 (B). Merged channels showed colocalization (C). Chloroplast autofluorescence is shown in blue. Scale: 50μm. (D-I).
Yannick Bellec (2142490), Kian Hematy (111261), Charlotte Renne (1783144), Johnathan Napier (3095556), Lionel Gissot (527359), Frédéric Beaudoin (3095559), Jean-Denis Faure (2142481), Richard Haslam (3095562), Céline Morineau (2142493), Frédérique Tellier (3095565)   +9 more
core   +1 more source

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
Metabolic reprogramming in cancer stem cells: lipid flux, mitochondrial plasticity, and therapeutic resistance. Lipid metabolism in CSCs: de novo lipogenesis, CD36 uptake, FAO, lipid droplets, and membrane remodeling. Mitochondrial dynamics in CSC survival: fusion, fission, mitophagy, OXPHOS switching, and ROS regulation.
Daniel Ejim Uti, Esther Ugo Alum, Josephine E. Egbung, Zuhair M. Mohammedsaleh, Manpreet Kaur, Kranti Kiran Reddy Ealla   +5 more
wiley   +1 more source

Regulation of Rat Hepatic Elongase and Desaturase Expression

The FASEB Journal, 2006
Hepatic fatty acid elongases (Elovl‐1, ‐2, ‐5 & ‐6) and desaturases [delta‐5 (D5D), delta‐6 (D6D), delta‐9 (D9D)] play an important role in hepatic and whole body lipid composition. In contrast to the desaturases, little is known about the control of elongase expression.
Yun Wang, Daniela Botolin, Jinghua Xu, Barbara Christian, Donald B Jump   +4 more
openaire   +1 more source

Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs

Animal, 2012
Studies suggested that in human adults, linoleic acid (LA) inhibits the biosynthesis of n-3 long-chain polyunsaturated fatty acids (LC-PUFA), but their effects in growing subjects are largely unknown.
W. Smink, W.J.J. Gerrits, M. Gloaguen, A. Ruiter, J. van Baal   +4 more
doaj   +1 more source

Egg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A novel shad egg peptide (EP) significantly extends Caenorhabditis elegans lifespan through a dual antiaging mechanism. EP systematically remodels lipid metabolism to reinforce cell membranes by promoting beneficial fatty acid biosynthesis and suppressing degradation. Simultaneously, its potent antioxidant activity alleviates oxidative damage, shifting
Jia Du, Qinghua Liu, Zhongxiao Wan, Naomi Sudo, Yanyang Xu   +4 more
wiley   +1 more source

Zebrafish cDNA encoding multifunctional fatty acid elongase involved in production of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids [PDF]

, 2004
Enzymes that increase the chain length of fatty acids are essential for biosynthesis of highly unsaturated fatty acids. The gLELO gene encodes a protein involved in the elongation of polyunsaturated fatty acids in the fungus Mortierella alpina.
Teale, Alan J, Dickson, Cathryn, Tocher, Douglas R, Agaba, Morris K, Dick, James R   +4 more
core   +1 more source

Construction of DGLA producing cell factory by genetic modification of Mucor circinelloides

Microbial Cell Factories, 2019
Background Dihomo-gamma linolenic acid (DGLA, 20:3, n-6) is the elongated product of Gamma linolenic acid (GLA, 18:3, n-6) catalyzed by the enzyme delta-6 elongase (D6E) or gamma linolenic acid elongase (GLELO).
Md. Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Li Liang, Victoriano Garre, Yuanda Song   +6 more
doaj   +1 more source