Results 31 to 40 of about 3,553 (153)

The LXRB-SREBP1 network regulates lipogenic homeostasis by controlling the synthesis of polyunsaturated fatty acids in goat mammary epithelial cells

Journal of Animal Science and Biotechnology, 2022
Background In rodents, research has revealed a role of liver X receptors (LXR) in controlling lipid homeostasis and regulating the synthesis of polyunsaturated fatty acids (PUFA).
Wenying Zhang, Changhui Zhang, Jun Luo, Huifen Xu, Jianxin Liu, Juan J. Loor, Hengbo Shi   +6 more
doaj   +1 more source

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Frontiers in Molecular Neuroscience, 2021
BackgroundLipids are a primary storage form of energy and the source of inflammatory and pain signaling molecules, yet knowledge of their importance in chronic migraine (CM) pathology is incomplete.
Katherine Castor, Jessica Dawlaty, Xianghong Arakaki, Xianghong Arakaki, Noah Gross, Yohannes W. Woldeamanuel, Michael G. Harrington, Michael G. Harrington, Michael G. Harrington, Robert P. Cowan, Alfred N. Fonteh, Alfred N. Fonteh   +11 more
doaj   +1 more source

Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice. [PDF]

PLoS ONE, 2011
BACKGROUND: Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored lipids, thus mobilizing fatty acids.
Céline Fernandez, Kai Schuhmann, Ronny Herzog, Barbara Fielding, Keith Frayn, Andrej Shevchenko, Peter James, Cecilia Holm, Kristoffer Ström   +8 more
doaj   +1 more source

Analyzing the role of lipid elongases in Drosophila development: From barriers to behavior

, 2014
Long chain fatty acids (LCFA) constitute a particular class of lipids whose developmental roles are coming under increasing scrutiny. These LCFAs not only have important cell specific functions but their dysregulation also forms the underlying cause of ...
Gupta, Prachi
core   +3 more sources

Isolation and Characterization of the Diatom Phaeodactylum Δ5-Elongase Gene for Transgenic LC-PUFA Production in Pichia pastoris

Marine Drugs, 2014
The diatom Phaeodactylum tricornutum can accumulate eicosapentaenoic acid (EPA) up to 30% of the total fatty acids. This species has been targeted for isolating gene encoding desaturases and elongases for long-chain polyunsaturated fatty acid (LC-PUFA ...
Mulan Jiang, Bing Guo, Xia Wan, Yangmin Gong, Yinbo Zhang, Chuanjiong Hu   +5 more
doaj   +1 more source

Effects of Dietary α-Linolenic Acid Treatment and the Efficiency of Its Conversion to Eicosapentaenoic and Docosahexaenoic Acids in Obesity and Related Diseases

Molecules, 2022
The essential fatty acid alpha-linolenic acid (ALA) is present in high amounts in oils such as flaxseed, soy, hemp, rapeseed, chia, and perilla, while stearidonic acid is abundant in echium oil.
Marija Takic, Biljana Pokimica, Gordana Petrovic-Oggiano, Tamara Popovic   +3 more
doaj   +1 more source

Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis

Journal of Lipid Research, 2004
In algae, the biosynthesis of docosahexaenoic acid (22:6ω3; DHA) proceeds via the elongation of eicosapentaenoic acid (20:5ω3; EPA) to 22:5ω3, which is required as a substrate for the final Δ4 desaturation. To isolate the elongase specific for this step,
Astrid Meyer, Helene Kirsch, Frédéric Domergue, Amine Abbadi, Petra Sperling, Jörg Bauer, Petra Cirpus, Thorsten K. Zank, Hervé Moreau, Thomas J. Roscoe, Ulrich Zähringer, Ernst Heinz   +11 more
doaj   +1 more source

Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERα in Breast Cancer Cells. [PDF]

PLoS ONE, 2016
Endocrine therapy is the first-line targeted adjuvant therapy for hormone-sensitive breast cancer. In view of the potential anticancer property of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) together with chemotherapy in estrogen ...
Amanda González-Bengtsson, Abolfazl Asadi, Hui Gao, Karin Dahlman-Wright, Anders Jacobsson   +4 more
doaj   +1 more source

Biosynthesis of Polyunsaturated Fatty Acids in the Oleaginous Marine Diatom Fistulifera sp. Strain JPCC DA0580

Marine Drugs, 2013
Studies of polyunsaturated fatty acid (PUFA) biosynthesis in microalgae are of great importance for many reasons, including the production of biofuel and variable omega 3-long chain PUFAs. The elucidation of the PUFA biosynthesis pathway is necessary for
Yue Liang, Yoshiaki Maeda, Yoshihiko Sunaga, Masaki Muto, Mitsufumi Matsumoto, Tomoko Yoshino, Tsuyoshi Tanaka   +6 more
doaj   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source