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The King is Dead, Long Live the King: Entering A New Era of Stem Cell Research and Clinical Development [PDF]
Journal of Translational Medicine, 2011 In mid November the biopharma industry was shocked by the announcement from Geron that they were ending work on embryonic stem cell research and therapy.
Ichim Thomas +2 more
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Early Acquisition of Neural Crest Competence During hESCs Neuralization [PDF]
, 2010 Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates.
Bronner-Fraser, Marianne +8 more
core +20 more sources
Cell Proliferation, 2004 Embryonic stem cells have huge potential in the field of tissue engineering and regenerative medicine as they hold the capacity to produce every type of cell and tissue in the body. In theory, the treatment of human disease could be revolutionized by the ability to generate any cell, tissue, or even organ, 'on demand' in the laboratory.
H J, Rippon, A E, Bishop
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Stem Cell Research, 2021 Marfan Syndrome (MFS) is a pleiotropic and autosomal dominant condition caused by pathogenic variants in FBN1. Although fully penetrant, clinical variability is frequently observed among patients and there are only few genotype-phenotype correlations ...
Juliana Borsoi +7 more
doaj +1 more source
Inter-species Transplantation of Blastocysts between Medaka and Zebrafish
Bio-Protocol, 2021 Transplantation of blastocysts from a donor to a host blastula constitutes a powerful experimental tool to tackle major developmental biology questions. The technique is widely implemented in diverse biological models including teleost fish, where it is ...
Jana Fuhrmann +2 more
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The Journal of Pathology, 2002 AbstractThe capacity of embryonic stem cells for virtually unlimited self‐renewal and differentiation capacity has opened up the prospect of widespread applications in biomedical research and regenerative medicine. For the latter, the cells provide hope that it will be possible to overcome the problems of donor tissue shortage and also, by making the ...
Anne E, Bishop +2 more
openaire +2 more sources
Stem Cell Research, 2021 Marfan Syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in the FBN1 gene. To investigate the molecular mechanisms of pathogenesis for the syndrome, we genetically modified the FBN1 gene in a line of induced ...
Juliana Borsoi +5 more
doaj +1 more source
Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb [PDF]
, 2007 Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ...
C.H. Papadimitriou +8 more
core +4 more sources
Stem Cell Research, 2021 Hypertension is a complex multifactorial disease characterized by a chronic increase of arterial pressure. Ninety percent of the cases are idiopathic and thus classified as essential hypertension. Uncontrolled arterial pressure has devasting consequences
Raquel Sarafian +8 more
doaj +1 more source
Embryonic Stem Cell Markers [PDF]
Molecules, 2012 Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells. Understanding of the functions of these markers is critical for characterization and elucidation for the mechanism of ESC pluripotent maintenance and self-renewal, therefore helping to accelerate the clinical application of ES cells.
Lan Ma +4 more
openaire +3 more sources