Results 1 to 10 of about 1,366,989 (255)

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1993
A. Nagy, J. Rossant, R. Nagy, W. Abramow-Newerly, J. Roder   +4 more
semanticscholar   +2 more sources

Early Acquisition of Neural Crest Competence During hESCs Neuralization [PDF]

, 2010
Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates.
Bronner-Fraser, Marianne, Cattarossi, Giulio, Cimadamore, Flavio, Curchoe, Carol Lynn, Maurer, Jochen, McKeown, Sonja J., Nilbratt, Mats, Snyder, Evan Y., Terskikh, Alexey V.   +8 more
core   +25 more sources

Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients

Stem Cell Research, 2021
Marfan Syndrome (MFS) is a pleiotropic and autosomal dominant condition caused by pathogenic variants in FBN1. Although fully penetrant, clinical variability is frequently observed among patients and there are only few genotype-phenotype correlations ...
Juliana Borsoi, Mariana Morato-Marques, Fabiano de Araújo Tofoli, Lucas Assis Pereira, Luis Ernesto Farinha-Arcieri, Raquel Delgado Sarafian, Ana Beatriz Alvarez Perez, Lygia Veiga Pereira   +7 more
doaj   +1 more source

Inter-species Transplantation of Blastocysts between Medaka and Zebrafish

Bio-Protocol, 2021
Transplantation of blastocysts from a donor to a host blastula constitutes a powerful experimental tool to tackle major developmental biology questions. The technique is widely implemented in diverse biological models including teleost fish, where it is ...
Jana Fuhrmann, Jasmin Onistschenko, Lazaro Centanin   +2 more
doaj   +1 more source

Generation of genetically modified human induced pluripotent stem cell lines harboring haploin sufficient or dominant negative variants in the FBN1 gene

Stem Cell Research, 2021
Marfan Syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in the FBN1 gene. To investigate the molecular mechanisms of pathogenesis for the syndrome, we genetically modified the FBN1 gene in a line of induced ...
Juliana Borsoi, Luis Ernesto Farinha-Arcieri, Mariana Morato-Marques, Raquel Delgado Sarafian, Mara Pinheiro, Lygia Veiga Pereira   +5 more
doaj   +1 more source

Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb [PDF]

, 2007
Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ...
C.H. Papadimitriou, D. Eppstein, D.D. Sleator, D.E. Knuth, K.M. Lillis, P. Angelini, R. Dhandapani, R.B. Muhammad, T. Leighton   +8 more
core   +4 more sources

Generation of 6 lines of human pluripotent stem cells from hypertensive patients and 3 lines of human pluripotent stem cell from normotensive patients

Stem Cell Research, 2021
Hypertension is a complex multifactorial disease characterized by a chronic increase of arterial pressure. Ninety percent of the cases are idiopathic and thus classified as essential hypertension. Uncontrolled arterial pressure has devasting consequences
Raquel Sarafian, Mariana Morato-Marques, Juliana Borsoi, Fabiano Tófoli-Araújo, Mara Pinheiro, Yordanka Medina-Armenteros, Paulo A. Lotufo, Isabela M. Bensenor, Lygia V. Pereira   +8 more
doaj   +1 more source

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]

, 2017
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di, Clark, Amander T, Gkountela, Sofia, Hennebold, Jon D, Liu, Wanlu, Orwig, Kyle E, Sosa, Enrique, Sukhwani, Meena   +7 more
core   +5 more sources

ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
doaj   +1 more source

Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Scientific Reports, 2021
In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance ...
Ana Luíza Cidral, Joana C. Moreira de Mello, Joost Gribnau, Lygia V. Pereira   +3 more
doaj   +1 more source