Results 1 to 10 of about 306,996 (162)

Embryonic stem cells [PDF]

Cell Proliferation, 2004
Embryonic stem cells have huge potential in the field of tissue engineering and regenerative medicine as they hold the capacity to produce every type of cell and tissue in the body. In theory, the treatment of human disease could be revolutionized by the ability to generate any cell, tissue, or even organ, 'on demand' in the laboratory.
H J, Rippon, A E, Bishop
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Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients

Stem Cell Research, 2021
Marfan Syndrome (MFS) is a pleiotropic and autosomal dominant condition caused by pathogenic variants in FBN1. Although fully penetrant, clinical variability is frequently observed among patients and there are only few genotype-phenotype correlations ...
Juliana Borsoi, Mariana Morato-Marques, Fabiano de Araújo Tofoli, Lucas Assis Pereira, Luis Ernesto Farinha-Arcieri, Raquel Delgado Sarafian, Ana Beatriz Alvarez Perez, Lygia Veiga Pereira   +7 more
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Embryonic stem cells [PDF]

The Journal of Pathology, 2002
AbstractThe capacity of embryonic stem cells for virtually unlimited self‐renewal and differentiation capacity has opened up the prospect of widespread applications in biomedical research and regenerative medicine. For the latter, the cells provide hope that it will be possible to overcome the problems of donor tissue shortage and also, by making the ...
Anne E, Bishop, Lee D K, Buttery, Julia M, Polak   +2 more
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Inter-species Transplantation of Blastocysts between Medaka and Zebrafish

Bio-Protocol, 2021
Transplantation of blastocysts from a donor to a host blastula constitutes a powerful experimental tool to tackle major developmental biology questions. The technique is widely implemented in diverse biological models including teleost fish, where it is ...
Jana Fuhrmann, Jasmin Onistschenko, Lazaro Centanin   +2 more
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Generation of genetically modified human induced pluripotent stem cell lines harboring haploin sufficient or dominant negative variants in the FBN1 gene

Stem Cell Research, 2021
Marfan Syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in the FBN1 gene. To investigate the molecular mechanisms of pathogenesis for the syndrome, we genetically modified the FBN1 gene in a line of induced ...
Juliana Borsoi, Luis Ernesto Farinha-Arcieri, Mariana Morato-Marques, Raquel Delgado Sarafian, Mara Pinheiro, Lygia Veiga Pereira   +5 more
doaj   +1 more source

Generation of 6 lines of human pluripotent stem cells from hypertensive patients and 3 lines of human pluripotent stem cell from normotensive patients

Stem Cell Research, 2021
Hypertension is a complex multifactorial disease characterized by a chronic increase of arterial pressure. Ninety percent of the cases are idiopathic and thus classified as essential hypertension. Uncontrolled arterial pressure has devasting consequences
Raquel Sarafian, Mariana Morato-Marques, Juliana Borsoi, Fabiano Tófoli-Araújo, Mara Pinheiro, Yordanka Medina-Armenteros, Paulo A. Lotufo, Isabela M. Bensenor, Lygia V. Pereira   +8 more
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Embryonic Stem Cell Markers [PDF]

Molecules, 2012
Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells. Understanding of the functions of these markers is critical for characterization and elucidation for the mechanism of ESC pluripotent maintenance and self-renewal, therefore helping to accelerate the clinical application of ES cells.
Lan Ma, Liang Li, Wenxiu Zhao, Xiang Ji, Fangfang Zhang   +4 more
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ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
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Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Scientific Reports, 2021
In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance ...
Ana Luíza Cidral, Joana C. Moreira de Mello, Joost Gribnau, Lygia V. Pereira   +3 more
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ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways

Journal of Advanced Research, 2023
Introduction: High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood.
Zongli Zhang, Yue Yuan, Lin Hu, Jian Tang, Zhongji Meng, Longjun Dai, Yujiu Gao, Shinan Ma, Xiaoli Wang, Yahong Yuan, Qiufang Zhang, Weibin Cai, Xuzhi Ruan, Xingrong Guo   +13 more
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