Results 1 to 10 of about 1,375,365 (258)

Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients

Stem Cell Research, 2021
Marfan Syndrome (MFS) is a pleiotropic and autosomal dominant condition caused by pathogenic variants in FBN1. Although fully penetrant, clinical variability is frequently observed among patients and there are only few genotype-phenotype correlations ...
Juliana Borsoi, Mariana Morato-Marques, Fabiano de Araújo Tofoli, Lucas Assis Pereira, Luis Ernesto Farinha-Arcieri, Raquel Delgado Sarafian, Ana Beatriz Alvarez Perez, Lygia Veiga Pereira   +7 more
doaj   +1 more source

Inter-species Transplantation of Blastocysts between Medaka and Zebrafish

Bio-Protocol, 2021
Transplantation of blastocysts from a donor to a host blastula constitutes a powerful experimental tool to tackle major developmental biology questions. The technique is widely implemented in diverse biological models including teleost fish, where it is ...
Jana Fuhrmann, Jasmin Onistschenko, Lazaro Centanin   +2 more
doaj   +1 more source

Generation of genetically modified human induced pluripotent stem cell lines harboring haploin sufficient or dominant negative variants in the FBN1 gene

Stem Cell Research, 2021
Marfan Syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in the FBN1 gene. To investigate the molecular mechanisms of pathogenesis for the syndrome, we genetically modified the FBN1 gene in a line of induced ...
Juliana Borsoi, Luis Ernesto Farinha-Arcieri, Mariana Morato-Marques, Raquel Delgado Sarafian, Mara Pinheiro, Lygia Veiga Pereira   +5 more
doaj   +1 more source

Generation of 6 lines of human pluripotent stem cells from hypertensive patients and 3 lines of human pluripotent stem cell from normotensive patients

Stem Cell Research, 2021
Hypertension is a complex multifactorial disease characterized by a chronic increase of arterial pressure. Ninety percent of the cases are idiopathic and thus classified as essential hypertension. Uncontrolled arterial pressure has devasting consequences
Raquel Sarafian, Mariana Morato-Marques, Juliana Borsoi, Fabiano Tófoli-Araújo, Mara Pinheiro, Yordanka Medina-Armenteros, Paulo A. Lotufo, Isabela M. Bensenor, Lygia V. Pereira   +8 more
doaj   +1 more source

ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
doaj   +1 more source

Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Scientific Reports, 2021
In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance ...
Ana Luíza Cidral, Joana C. Moreira de Mello, Joost Gribnau, Lygia V. Pereira   +3 more
doaj   +1 more source

ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways

Journal of Advanced Research, 2023
Introduction: High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood.
Zongli Zhang, Yue Yuan, Lin Hu, Jian Tang, Zhongji Meng, Longjun Dai, Yujiu Gao, Shinan Ma, Xiaoli Wang, Yahong Yuan, Qiufang Zhang, Weibin Cai, Xuzhi Ruan, Xingrong Guo   +13 more
doaj   +1 more source

Monitoring cell line identity in collections of human induced pluripotent stem cells

Stem Cell Research, 2018
The ability to reprogram somatic cells into induced pluripotent stem cells (hiPSCs) has led to the generation of large collections of cell lines from thousands of individuals with specific phenotypes, many of which will be shared among different research
Raquel Sarafian, Mariana Morato-Marques, Juliana Borsoi, Lygia Veiga Pereira   +3 more
doaj   +1 more source

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

Science, 2020
Trunk formation in a dish Building mammalian embryos from self-organizing stem cells in culture would accelerate the investigation of morphogenetic and differentiation processes that shape the body plan. Veenvliet et al.
Jesse V. Veenvliet, Adriano Bolondi, H. Kretzmer, Leah Haut, Manuela Scholze-Wittler, Dennis Schifferl, Frederic Koch, L. Guignard, Abhishek Sampath Kumar, Milena Pustet, Simon Heimann, René Buschow, L. Wittler, B. Timmermann, A. Meissner, B. Herrmann   +15 more
semanticscholar   +1 more source

Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment. [PDF]

PLoS ONE, 2017
The embryonic microenvironment is well known to be non-permissive for tumor development because early developmental signals naturally suppress the expression of proto-oncogenes.
Shufeng Zhou, Mohamed Abdouh, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena   +4 more
doaj   +1 more source