Results 21 to 30 of about 3,265,586 (282)

Enantioselective Synthesis of (−)-Acetylapoaranotin

Organic Letters, 2017
The first enantioselective total synthesis of the epipolythiodiketopiperazine (ETP) natural product (-)-acetylapoaranotin (3) is reported. The concise synthesis was enabled by an eight-step synthesis of a key cyclohexadienol-containing amino ester building block.
Haoxuan Wang, Clinton J. Regan, Julian A. Codelli, Paola Romanato, Angela L. A. Puchlopek-Dermenci, Sarah E. Reisman   +5 more
openaire   +5 more sources

Ferrocene-derived P,N ligands : synthesis and application in enantioselective catalysis [PDF]

, 2013
Due to their unique steric and electronic properties, air-stability and modular structure, chiral hybrid P,N-ferrocenyl ligands play a prominent role in the field of asymmetric catalysis.
Noël, Timothy, Van der Eycken, Johan
core   +1 more source

Enantioselective Total Synthesis of (+)‐Garsubellin A [PDF]

Angewandte Chemie International Edition, 2021
AbstractGarsubellin A is a meroterpene capable of enhancing the enzyme choline acetyltransferase whose decreased level is believed to play a central role in the symptoms of Alzheimer's disease. Due to the potentially useful biological activity together with the novel bridged and fused cyclic molecular architecture, garsubellin A has garnered ...
Jinglong Chen, Jinglong Chen, Minchul Choi, Chulbom Lee, Dongseok Jang   +4 more
openaire   +4 more sources

Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides.

Journal of the American Chemical Society, 2020
We report an iodoarene-catalyzed enantioselective synthesis of β,β-difluoroalkyl halide building blocks. The transformation involves an oxidative rearrangement of α-bromostyrenes, utilizing HF-pyridine as the fluoride source and m-CPBA as the ...
M. Levin, John M. Ovian, Jacquelyne A. Read, M. Sigman, E. Jacobsen   +4 more
semanticscholar   +1 more source

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine [PDF]

, 2008
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient
Adriaan J. Minnaard, Albrow, Alexakis, Alexakis, Anderson, Bach, Back, Beak, Beak, Beak, Beak, Beak, Beak, Beak, Ben L. Feringa, Bennett, Bennett, Berkheij, Bertini Gross, Brooks, Comins, Comins, Comins, Comins, Comins, Comins, Comins, Curtin, d'Augustin, Davis, Dieter, Dieter, Dieter, Dieter, Dieter, Eilitz, Frankel, Fraser, Gallagher, Garcia-Ruiz, Gardette, Gelas-Mialhe, Hoffmann, Houk, Kerrick, King, Leclercq, Liang, Maria Gabriella Pizzuti, Pilli, Pilli, Pineschi, Pàmies, Remuson, Slosse, Slosse, Still, Tawara, Vuagnoux-d'Augustin, Vuagnoux-d'Augustin, Watson, Whisler, Šebesta   +62 more
core   +1 more source

Enantioselective Synthesis of (−)-Basiliskamide A [PDF]

Organic Letters, 2012
Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available β-hydroxy ester 7.
William R. Roush, Ming Chen
openaire   +3 more sources

Enantioselective Total Synthesis of (+)-Cassiol [PDF]

, 2009
An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd-2(pmdba)(3) and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early ...
Mohr, Justin T., Petrova, Krastina V., Stoltz, Brian M.   +2 more
core   +2 more sources

Enantioenriched α-substituted glutamates/pyroglutamates via enantioselective cyclopropenimine-catalyzed Michael addition of amino ester imines

Beilstein Journal of Organic Chemistry, 2021
A procedure for the enantioselective synthesis of α-substituted glutamates and pyroglutamates via a cyclopropenimine-catalyzed Michael addition of amino ester imines is described.
Zara M. Seibel, Jeffrey S. Bandar, Tristan H. Lambert   +2 more
doaj   +1 more source

Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis [PDF]

, 2014
An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning ...
Aldegunde M. J., Aldegunde M. J., Aldegunde M. J., Aurélien Letort, Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Bourgeois D., Chatterjee A. K., Cong Ma, De-Liang Long, Doi T., Garber S. B., Goldring P. D., Grieco P. A., Holton R. A., Holton R. A., Joëlle Prunet, Kim S.-H., Ma C., Masters J. J., Mendoza A., Morihara K., Mukaiyama T., Muller B., Muller B., Nicolaou K. C., Rémi Aouzal, Schiltz S., Scholl M., Schwab P., Swindell C. S., Wender P. A., Wender P. A., Wilde N. C., Winkler J. D., Yamazaki Y., Yared J. A., Yvon D.   +39 more
core   +3 more sources

Enantioselective Synthesis of (−)‐Halenaquinone

Angewandte Chemie International Edition, 2018
AbstractThe efficient, 12–14 step (LLS) total synthesis of (−)‐halenaquinone has been achieved. Key steps in the synthetic sequence include: (a) proline sulfonamide‐catalyzed, Yamada–Otani reaction to establish the C6 all‐carbon quaternary stereocenter, (b) multiple, novel palladium‐mediated oxidative cyclizations to introduce the furan moiety, and (c) 
Subir Goswami, Mohamed F. El-Mansy, Rajinikanth Lingampally, Kenichi Harada, Kenichi Harada, Rich G. Carter   +5 more
openaire   +4 more sources