Results 51 to 60 of about 85,052 (233)

Palladium-catalyzed asymmetric carbene coupling en route to inherently chiral heptagon-containing polyarenes

Nature Communications
Developing facile and direct synthesis routes for enantioselective construction of cyclic π-conjugated molecules is crucial. However, originate chirality from the distorted structure around heptagon-containing polyarenes is largely overlooked, the ...
Huan Zhang, Chuan-Jun Lu, Gao-Hui Cai, Long-Long Xi, Jia Feng, Ren-Rong Liu   +5 more
doaj   +1 more source

Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J

Nature Communications, 2020
Despite being known for more than 50 years, yuzurimine-type alkaloids have not been accessed by total synthesis. Here, the authors report the first enantioselective total synthesis of (+)-Caldaphnidine J, a highly complex yuzurimine-type Daphniphyllum ...
Lian-Dong Guo, Yan Zhang, Jingping Hu, Chengqing Ning, Heyifei Fu, Yuye Chen, Jing Xu   +6 more
doaj   +1 more source

Enantioselective Synthesis of (−)‐Halenaquinone

Angewandte Chemie International Edition, 2018
AbstractThe efficient, 12–14 step (LLS) total synthesis of (−)‐halenaquinone has been achieved. Key steps in the synthetic sequence include: (a) proline sulfonamide‐catalyzed, Yamada–Otani reaction to establish the C6 all‐carbon quaternary stereocenter, (b) multiple, novel palladium‐mediated oxidative cyclizations to introduce the furan moiety, and (c) 
Subir Goswami, Kenichi Harada, Mohamed F. El‐Mansy, Rajinikanth Lingampally, Rich G. Carter   +4 more
openaire   +4 more sources

Formal Enantioselective Synthesis of (+)-Compactin [PDF]

Organic Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Joël, Robichaud, François, Tremblay
openaire   +2 more sources

Enantioselective desymmetrization strategy of prochiral 1,3-diols in natural product synthesis

Beilstein Journal of Organic Chemistry
Enantioselective desymmetrization is employed as a powerful tool for the creation of chiral centers. Within this scope, the enantioselective desymmetrization of prochiral 1,3-diols, which generates chiral centers by enantioselective functionalization of ...
Lihua Wei, Rui Yang, Zhifeng Shi, Zhiqiang Ma   +3 more
doaj   +1 more source

Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

Nature Communications, 2021
Chiral acetylenic derivatives are found in many bioactive compounds and are versatile building blocks in organic synthesis. Here, the authors report a mild enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction which is
Xihao Chang, Jiayin Zhang, Lingzi Peng, Chang Guo   +3 more
doaj   +1 more source

Highly Diastereo- and Enantioselective Allylboration of Aldehydes using alpha-Substituted Allyl/Crotyl Pinacol Boronic Esters via in Situ Generated Borinic Esters [PDF]

, 2013
Readily available, alpha-substituted allyl/crotyl pinacol boronic esters often give low E/Z selectivity (with Z favored) in reactions with aldehydes. We found that addition of nBuLi to the pinacol boronic ester followed by trapping of the alkoxide with ...
Althaus M., Andersen M. W., Batey R. A., Batey R. A., Beckmann E., Blais J., Brown H. C., Brown H. C., Brown H. C., Brown H. C., Bubnov Y. N., Carosi L., Carosi L., Chemler S. R., Chen M., Chen M., Christine L. Willis, Cmrecki V., Cole T. E., Denmark S. E., Fang G. Y., Flamme E. M., Gonzalez A. Z., Guzman-Martinez A., Hancock K. G., Helen K. Scott, Hesse M. J., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Ito H., Jack L.-Y. Chen, Kennedy J. W. J., Kister J., Kliman L. T., Kramer G. W., Lachance H., Larouche-Gauthier R., Matteson D. S., Matthew J. Hesse, Midland M. M., Park J. K., Pelz N. F., Peng F., Peng F., Pietruszka J., Pietruszka J., Posseme F., Pulis A., Ramachandran P. V., Shiner C. S., Sonawane R. P., Stymiest J. L., Varinder K. Aggarwal, Webster M. P., Woodward A. R., Yamamoto Y., Zschage O.   +60 more
core   +2 more sources

Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides

Beilstein Journal of Organic Chemistry, 2017
Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination.
Ryota Miyaji, Yuuki Wada, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara   +4 more
doaj   +1 more source

Focus on chirality of HIV-​1 non-​nucleoside reverse transcriptase inhibitors [PDF]

, 2016
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Famiglini, Valeria, Silvestri, Romano
core   +2 more sources

Photoenzymatic catalysis enables enantioselective radical dearomative spirocyclization

Nature Communications
Dearomatization offers a powerful route towards three-dimensional spirocyclic architectures, which are pivotal in bioactive molecules and pharmaceuticals, particularly for enantioselective construction of congested quaternary spirocenters.
Changtong Zhu, Yan Zhang, Zhiwei Deng, Luyun Ji, Xiaorui Chen, Dejing Yin, Changmei Liu, Zhengshan Luo, Yijian Rao, Zhenbo Yuan   +9 more
doaj   +1 more source