Results 161 to 170 of about 39,817 (294)

Coordinative Ring‐Opening Polymerization of Limonene Carbamate towards Phosgene‐ and Isocyanate‐Free Polyurethane

Angewandte Chemie International Edition, Accepted Article.
This study presents a phosgene‐ and isocyanate‐free route for the synthesis of polyurethanes using (R)‐limonene as a bio‐based starting material. The synthesis of the cyclic limonene‐based carbamate monomer LU is achieved in high yields using dimethyl carbonate as a sustainable, less hazardous phosgene surrogate and is verified by NMR, SC‐XRD, ESI‐MS ...
Jonas Futter, Leon Ferdinand Richter, Stefanie Hörl, Bernhard Rieger, Moritz Kränzlein   +4 more
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Charge Relocation Enables a Modular and Diastereoselective Synthesis of cis‐Substituted Tetrahydrofurans

Angewandte Chemie International Edition, EarlyView.
A disconnection model in which acylium ions generated from acyl chlorides are treated with variety of alkenes is reported for the synthesis of 2,5‐cis‐disubstituted tetrahydrofurans (THFs) and other THF derivatives. A charge relocation process leads to the formation of oxocarbenium ions, which are reduced to the desired THF structures.
Zhi‐Jie Niu, Bogdan R. Brutiu, Margaux Riomet, Daniel Kaiser, Nuno Maulide   +4 more
wiley   +1 more source

Influence of Ligand Design and Non‐Covalent Interactions on the Isoselective Ring‐Opening Polymerization of rac‐β‐Butyrolactone Using Salan and Salalen Rare‐Earth Metal Catalysts

Angewandte Chemie International Edition, EarlyView.
Polyhydroxybutyrates are key sustainable polyesters, but controlling the stereoregularity is crucial for exhibiting the most promising thermal and mechanical properties. Highly active rare‐earth metal salan/salalen complexes yield isotactic (Pm up to 0.96 at 0 °C) or syndioenriched (Pr up to 0.91) PHB, depending on the steric demand of the ligand and ...
Stefanie Hörl, Ion Chiorescu, Jonas Bruckmoser, Jonas Futter, Bernhard Rieger   +4 more
wiley   +1 more source

Chirality‐Induced Hydroxyapatite Manipulates Enantioselective Bone‐Implant Interactions Toward Ameliorative Osteoporotic Osseointegration

Advanced Science
Inspired by the fundamental attribute of chirality in nature, chiral‐engineered biomaterials now represent a groundbreaking frontier in biomedical fields.
Liang Yang, Jinzhou Du, Shengyang Jin, Shuyi Yang, Zhaowei Chen, Shiyang Yu, Cunyi Fan, Chao Zhou, Hongjiang Ruan   +8 more
doaj   +1 more source

Three‐Component Radical Cross‐Coupling: Asymmetric Vicinal Sulfonyl‐Esterification of Alkenes Involving Sulfur Dioxide

Advanced Science
A novel catalytic system for radical cross‐coupling reactions based on copper and chiral Pyridyl‐bis(imidazole) (PyBim) ligands is described. It overcomes the challenges of chemoselectivity and enantioselectivity, achieving a highly enantioselective ...
Zhiqian Chang, Xuemei Zhang, Haiping Lv, Haotian Sun, Zhong Lian   +4 more
doaj   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, EarlyView.
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

Highly Enantioselective Organocatalysis with Bidentate Halogen Bond Donors

Angewandte Chemie International Edition, EarlyView.
In a model Mukaiyama aldol reaction with unbiased substrates, high enantioselectivity was achieved with a modifiable bidentate iodine(I)‐based halogen bonding organocatalyst. The crucial role of halogen bonding was confirmed by the low performance of the corresponding hydrogen bond donor and via DFT calculations.
Julian Wolf, Meghana Poliyodath Mohanan, Raphaël Robidas, Revannath L. Sutar, Elric Engelage, Claude Y. Legault, Stefan M. Huber   +6 more
wiley   +1 more source

Redirecting the Peptide Cleavage Causes Protease Inactivation

Angewandte Chemie International Edition, Accepted Article.
Cysteine and serine proteases cleave peptides through covalent catalysis by generating a transient adduct with the N‐terminal part of the substrate after releasing its C‐terminal part. We demonstrate the unique redirection of this event leading to strong enzyme inactivation.
Michael Gütschow, Christian Breuer, Jim Küppers, Anna-Christina Schulz-Fincke, Anna Heilos, Carina Lemke, Petra Spiwokowá, Janina Schmitz, Laura Cremer, Marta Frigolé-Vivas, Michael Lülsdorff, Matthias D. Mertens, Filip Wichterle, Miloš Apeltauer, Martin Horn, Erik Gilberg, Norbert Furtmann, Jürgen Bajorath, Ulrike Bartz, Bernd Engels, Michael Mareš   +20 more
wiley   +1 more source

Isothiourea‐Catalysed Acylative Kinetic and Dynamic Kinetic Resolution of Planar Chiral Paracyclophanols

Angewandte Chemie International Edition, Accepted Article.
The development of synthetic methods for the catalytic enantioselective preparation of planar chiral paracyclophane derivaties is of considerable interest to the synthetic community. To date, relatively few successful and effective organocatalytic approaches to this molecular class have been reported.
Andrew David Smith, Zhanyu Zhou, Kevin Kasten, Aidan P. McKay, David B. Cordes   +4 more
wiley   +1 more source