Results 91 to 100 of about 26,170 (225)
Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish [PDF]
, 2017 Isabel Forner-Piquer +8 more
openalex +1 more source
Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System [PDF]
, 2020 Hee-Yeon Kim +4 more
openalex +1 more source
European Journal of Pain, Volume 30, Issue 2, February 2026.ABSTRACT Background Chronic pain, which is often unrelated to ongoing injury, is poorly understood and difficult to treat. Genetic studies have identified voltage‐gated sodium (Nav) channels, particularly gain‐of‐function mutations such as L858F and R1150W in human NaV1.7, as involved in the development of chronic pain. Methods A chronic pain model was
Serena Mares Malta +7 more
wiley +1 more source
Astrocyte Regulation of Spinal Circuit Function
Journal of Neurochemistry, Volume 170, Issue 2, February 2026.Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff +2 more
wiley +1 more source
Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta
Mediators of Inflammation, 2015 Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of
Kanchan Vaswani +7 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.A detailed metabolome atlas of the male mouse brain was established, incorporating metabolomic and lipidomic profiling of seven anatomical regions. T2D induced marked metabolic alterations, which were mainly associated with lipotoxicity, defective energy metabolism, proinflammatory processes, and neurotoxicity.
Yang Zhou +5 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 2, 9 January 2026.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo +10 more
wiley +1 more source