Results 71 to 80 of about 26,170 (225)

The endocannabinoid system and stroke: A focused review

Brain Circulation, 2019
Stroke is an important cause of morbidity and mortality worldwide. Development of novel neuroprotectants is of paramount importance. This review seeks to summarize the recent evidence for the role of the endocannabinoid signaling system in stroke ...
Bradley Kolb, Hamidreza Saber, Hassan Fadel, Gary Rajah   +3 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm

Neurobiology of Disease, 2015
The endocannabinoid system serves as a retrograde negative feedback mechanism. It is thought to control neuronal activity in an epileptic neuronal network.
E.L. von Rüden, M. Jafari, R.M. Bogdanovic, C.T. Wotjak, H. Potschka   +4 more
doaj   +1 more source

The Endocannabinoid System , Hemostasis and Mental HealthDisorders-A Review [PDF]

, 2023

openalex   +1 more source

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

Low‐Load Quadriceps Strengthening With Blood Flow Restriction in Adults With Haemophilic Knee Arthropathy: A Randomised Controlled Trial

Haemophilia, EarlyView.
Abstract Introduction Haemophilic knee arthropathy leads to a reduction in muscle mass and strength. Blood flow restriction (BFR) involves the application of a compressive cuff that enables strength training with reduced loads. Objective To evaluate safety as the primary outcome and the efficacy (muscle strength and activation, functional capacity and ...
Mar Villalón‐González, Raúl Pérez‐Llanes, José Antonio López‐Pina, Rubén Cuesta‐Barriuso, Elena Donoso‐Úbeda   +4 more
wiley   +1 more source

Roadmap for the expression of canonical and extended endocannabinoid system receptors and metabolic enzymes in peripheral organs of preclinical animal models

Physiological Reports
The endocannabinoid system is widely expressed throughout the body and is comprised of receptors, ligands, and enzymes that maintain metabolic, immune, and reproductive homeostasis.
J. J. Rosado‐Franco, A. L. Ellison, C. J. White, A. S. Price, C. F. Moore, R. E. Williams, L. B. Fridman, E. M. Weerts, D. W. Williams   +8 more
doaj   +1 more source

Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression

Journal of Pharmacological Sciences, 2012
Ethanol is a wildly abused substance that causes various problems and damage in our society. We examined the connection between the action of ethanol and the endocannabinoid system in corticostriatal synaptic transmission by recording excitatory post ...
Hyeong Seok Cho, Seung Hyun Jeun, Qing-Zhong Li, Ki Jung Kim, Se Joon Choi, Ki-Wug Sung   +5 more
doaj   +1 more source

Endocannabinoid System and Ocular Vascularization

Nepalese Journal of Ophthalmology, 2018
The focus of this review is the role of endocannabinoid system in ocular and systemic circulation. By critically examining preclinical and clinical research, we explore the cannabinoid receptors localization and vascular implications as well as their interaction with other anti-inflammatory drugs.
Alina Popa Cherecheanu, Mohammad Al Hammoud, Cosmina Barac, Ioana-Cristina Coman, Raluca Iancu   +4 more
openaire   +3 more sources

Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice

Immunology, EarlyView.
The proposed mechanism by which Tui Na acupressure improves motor and cognitive dysfunction in ALS mice by activating the FoxP3/mTORC1 pathway. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune imbalance.
Jie Han, Xi Xu, Yan Zhao, Yao Xiao, Fei Huang, Jing Zhou, Hai Huang, Guiqian Wang   +7 more
wiley   +1 more source