Results 11 to 20 of about 571,172 (234)

Studying the Endothelial Glycocalyx in vitro: What Is Missing? [PDF]

Frontiers in Cardiovascular Medicine, 2021
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma proteins, called the glycocalyx. The glycocalyx transmits shear stress to the cytoskeleton of endothelial cells, maintains a selective permeability ...
Andrew B. Haymet, Andrew B. Haymet, Nicole Bartnikowski, Nicole Bartnikowski, Emily S. Wood, Emily S. Wood, Michael P. Vallely, Angela McBride, Angela McBride, Sophie Yacoub, Sophie Yacoub, Scott B. Biering, Eva Harris, Jacky Y. Suen, Jacky Y. Suen, John F. Fraser, John F. Fraser   +16 more
doaj   +2 more sources

Endothelial Glycocalyx in Aging and Age-related Diseases. [PDF]

Aging Dis, 2023
The worldwide population is aging exponentially, creating burdens to patients, their families and society. Increasing age is associated with higher risk of a wide range of chronic diseases, and aging of the vascular system is closely linked to the ...
Sun L, Wang L, Ye KX, Wang S, Zhang R, Juan Z, Feng L, Min S.   +7 more
europepmc   +2 more sources

Basal endothelial glycocalyx’s response to shear stress: a review of structure, function, and clinical implications

Frontiers in Cell and Developmental Biology
The endothelial glycocalyx encompasses the entire endothelial cell, transducing extracellular signals and regulating vascular permeability and barrier functions. The apical glycocalyx, which forms the lumen of the vessel, and the basal glycocalyx, at the
Zoe Vittum, Samantha Cocchiaro, Solomon A. Mensah, Solomon A. Mensah   +3 more
doaj   +2 more sources

Endothelial glycocalyx damage in kidney disease correlates with uraemic toxins and endothelial dysfunction

BMC Nephrology, 2021
Background Damage to the endothelial glycocalyx is an early indicator of vascular damage and a potential marker of endothelial dysfunction. This study aimed to assess the relationship between markers of glycocalyx damage, endothelial dysfunction, and ...
Hui Liew, Matthew A. Roberts, Alun Pope, Lawrence P. McMahon   +3 more
doaj   +2 more sources

Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury. [PDF]

Adv Sci (Weinh)
Circulating lactate is a critical biomarker for sepsis‐induced acute lung injury (S‐ALI) and is strongly associated with poor prognosis. However, whether elevated lactate directly promotes S‐ALI and the specific mechanism involved remain unclear.
Lu Z, Fang P, Li S, Xia D, Zhang J, Wu X, Pan J, Cai H, Fu L, Sun G, You Q.   +10 more
europepmc   +2 more sources

Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review

Annals of Intensive Care, 2020
The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans, secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such as albumin and antithrombin associated with the endothelial surface.
Cesar Aldecoa, Juan V. Llau, Xavier Nuvials, Antonio Artigas   +3 more
doaj   +2 more sources

Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit

ERJ Open Research, 2022
Accumulating evidence proves that endothelial dysfunction is involved in coronavirus disease 2019 (COVID-19) progression. We previously demonstrated that the endothelial surface glycocalyx has a critical role in maintenance of vascular integrity.
Lushun Yuan, Shuzhen Cheng, Wendy M.P.J. Sol, Anouk I.M. van der Velden, Hans Vink, Ton J. Rabelink, Bernard M. van den Berg   +6 more
doaj   +2 more sources

Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines

Annals of Intensive Care
Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of proteoglycans, glycosaminoglycans, and functional
Toshiaki Iba, Cheryl L. Maier, Julie Helms, Ricard Ferrer, Jecko Thachil, Jerrold H. Levy   +5 more
doaj   +2 more sources

Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis

Frontiers in Immunology, 2023
BackgroundDegradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor for the synthesis of glycosaminoglycans, plays a biological role in ...
Jiayun Ying, Caiyan Zhang, Yaodong Wang, Tingyan Liu, Zhenhao Yu, Kexin Wang, Weiming Chen, Yufeng Zhou, Yufeng Zhou, Yufeng Zhou, Guoping Lu   +10 more
doaj   +2 more sources

The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights [PDF]

Biomedicines
Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Martin Bender, Jan-Michael Abicht, Bruno Reichart, Maria Leuschen, Felicia Wall, Julia Radan, Elisabeth Neumann, Maren Mokelke, Ines Buttgereit, Sebastian Michel, Reinhard Ellgass, Katja Gieseke, Stig Steen, Audrius Paskevicius, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Martin B. Müller, Matthias Längin   +23 more
doaj   +2 more sources