Results 251 to 260 of about 141,342 (308)

Conserved enhancer association of piRNAs and the implication in germ cell fate surveillance. [PDF]

Genome Biol
Kung PJ, Tsai YT, Chungunco GML, Chang KW, Lin HH, Zhou SJ, Tseng YT, Cheng LC, Liao HF, Ju YR, Chung CY, Kuo HC, Namekawa SH, Ho HN, Chen HF, Laird DJ, Lin SP.   +16 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Differentially Methylated Regions in Human Rhombic Lip Compartments Are Enriched in Putative Active Enhancers, Human Accelerated Regions, and Medulloblastoma Copy Number Aberrations. [PDF]

Cerebellum
Sun X, Menon S, Wambo P, Lungu I, Birth Defects Research Laboratory, Aldinger KA, Pai S.   +6 more
europepmc   +1 more source

Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency. [PDF]

Nat Genet
Baderna V, Barzaghi G, Kleinendorst R, Chatsirisupachai K, Moniot-Perron L, Doyle C, Schopp M, Hochepied T, Libert C, Odom DT, Zaugg JB, Krebs AR.   +11 more
europepmc   +1 more source

A genome-wide survey reveals that a diverse array of enhancers coordinates the <i>Drosophila</i> innate immune response. [PDF]

Genome Res
Cohen LB, Hadzic T, Sauer C, Gibbs JR, Wunderlich Z.   +4 more
europepmc   +1 more source

Analysis of 14q12 microdeletions reveals novel regulatory loci for the neurodevelopmental disorder-related gene FOXG1. [PDF]

Nat Commun
Ramamurthy A, Bandouil MD, Aluru L, Joshi O, Yoon E, Bodkin N, Cheng JZ, Biar CG, Calhoun JD, Carvill GL.   +9 more
europepmc   +1 more source

Screening of known gut microbiome-derived metabolites in anti-tumor immunity of colorectal cancer. [PDF]

J Immunother Cancer
Zhang X, Li Z, Hua H, Song H, Qian S, Huang X, Ye G, Huang Y, Wang Q, Zheng B, Xu X, Li Y, Zhu Y, Yu L, Hong Y, Yuan H, Zhang J.   +16 more
europepmc   +1 more source

MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state.

Blood
Wang HC, Chen R, Yang W, Muthukumar R, Hu T, Patel RM, Casey EB, Denby E, Zhang R, Xie G, Ge K, Challen GA, Bednarski JJ, Magee JA.   +13 more
europepmc   +1 more source