Results 261 to 270 of about 127,657 (311)

Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator. [PDF]

Nucleic Acids Res
Mariner-Faulí M, Sánchez-Gaya V, Robert SM, Respuela P, de la Cruz-Molina S, Lobato-Moreno S, Trovato M, Prummel KD, Noh KM, Zaugg JB, Rada-Iglesias Á.   +10 more
europepmc   +1 more source

Extrusion fountains are hallmarks of chromosome organization emerging upon zygotic genome activation. [PDF]

Nat Commun
Galitsyna A, Ulianov SV, Bazarevich M, Bykov NS, Veil M, Gao M, Perevoschikova K, Gelfand MS, Razin SV, Mirny L, Onichtchouk D.   +10 more
europepmc   +1 more source

Typical Enhancers, Super-Enhancers, and Cancers

Cancers, 2022
Non-coding segments of the human genome are enriched in cis-regulatory modules that constitute functional elements, such as transcriptional enhancers and Super-enhancers. A hallmark of cancer pathogenesis is the dramatic dysregulation of the “archetype” gene expression profiles of normal human cells.
Marianna A Koutsi, Giannis Vatsellas, Christina Piperi   +2 more
exaly   +6 more sources

Super-enhancers include classical enhancers and facilitators to fully activate gene expression

Cell, 2023
Super-enhancers are compound regulatory elements that control expression of key cell identity genes. They recruit high levels of tissue-specific transcription factors and co-activators such as the Mediator complex and contact target gene promoters with ...
Joseph Blayney, Douglas R Higgs, Mira T Kassouf   +2 more
exaly   +3 more sources

Super-enhancers are transcriptionally more active and cell type-specific than stretch enhancers

Epigenetics, 2018
Super-enhancers and stretch enhancers represent classes of transcriptional enhancers that have been shown to control the expression of cell identity genes and carry disease- and trait-associated variants.
Aziz Khan, Anthony Mathelier, Xuegong Zhang   +2 more
exaly   +3 more sources

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ENHANCING EVOLUTION AND ENHANCING EVOLUTION

Bioethics, 2010
ABSTRACTIt has been claimed in several places that the new genetic technologies allow humanity to achieve in a generation or two what might take natural selection hundreds of millennia in respect of the elimination of certain diseases and an increase in traits such as intelligence.
openaire   +3 more sources

Are “Genetic Enhancements” Really Enhancements?

Cambridge Quarterly of Healthcare Ethics, 2000
The word enhancement is value laden and potentially misleading in the context of genetics. Dictionary definitions of enhance include “increase in value,” “improve,” “appreciate,” and “inflate.” The term genetic enhancement would be better replaced with a more neutral term such as “genetic manipulation” to reflect the fact that the consequences ...
openaire   +2 more sources

Distal enhancers loop to proximal enhancers, not to promoters

Nature Reviews Molecular Cell Biology
Kevin Struhl, Struhl Kevin
exaly   +4 more sources