Results 51 to 60 of about 46,429 (222)

The role of BDNF/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum

Frontiers in Systems Neuroscience, 2011
Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty, Alexandra J Bache, Nortorious T Coleman, Wei-Lun eSun   +3 more
doaj   +1 more source

Delta Opioid Receptors and Enkephalinergic Signaling within Locus Coeruleus Promote Stress Resilience

Brain Sciences, 2022
The noradrenergic nucleus locus coeruleus is a key component of the stress circuitry of the brain. During stress, the neuropeptide corticotropin-releasing factor (CRF) is secreted onto LC, increasing LC output and norepinephrine concentration in the ...
John A. Tkaczynski, Olga Borodovitsyna, Daniel J. Chandler   +2 more
doaj   +1 more source

Structure of the Energy Landscape of Short Peptides

, 2002
We have simulated, as a showcase, the pentapeptide Met-enkephalin (Tyr-Gly-Gly-Phe-Met) to visualize the energy landscape and investigate the conformational coverage by the multicanonical method.
Berg B. A., Berg B. A., Eisenmenger F., HANDAN ARKIN, Hansmann U. H. E., TARIK ÇELİK   +5 more
core   +1 more source

UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of Persea cordata (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

Chemistry &Biodiversity, EarlyView.
Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper, Daniela Hemsing, Julia Elisabett K. Bolsonello, Susana R. de Mello Schlemper, Tiago Tizziani, Lutuima A. Capangue Neto, Louis P. Sandjo   +6 more
wiley   +1 more source

Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders

Frontiers in Neural Circuits, 2022
Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date,
Sanne M. Casello, Rodolfo J. Flores, Hector E. Yarur, Huikun Wang, Monique Awanyai, Miguel A. Arenivar, Rosario B. Jaime-Lara, Rosario B. Jaime-Lara, Hector Bravo-Rivera, Hugo A. Tejeda   +9 more
doaj   +1 more source

Rugged Metropolis Sampling with Simultaneous Updating of Two Dynamical Variables [PDF]

, 2005
The Rugged Metropolis (RM) algorithm is a biased updating scheme, which aims at directly hitting the most likely configurations in a rugged free energy landscape. Details of the one-variable (RM$_1$) implementation of this algorithm are presented.
B. A. Berg, Bernd A. Berg, D. Frenkel, G. E. Schultz, Huan-Xiang Zhou, N. A. Alves, Y. Peng, Z. Li   +7 more
core   +1 more source

Easier, Safer, and Greener: Unlocking the Power of Solid Reagents in Organic Reactions by Mechanochemistry

ChemistryEurope, EarlyView.
This review highlights the powerful synergy between mechanochemistry and solid reagents to replace hazardous substances traditionally used in organic synthesis. Such an approach offers a safer and more sustainable pathway for conducting organic reactions, with potential benefits in both reactivity and selectivity. The use of solid bases, acids, and gas
Adrien Gallego, Nicolas Pétry, Julien Pinaud, Olivia Giani, Frédéric Lamaty   +4 more
wiley   +1 more source

Torsional path integral Monte Carlo method for the quantum simulation of large molecules [PDF]

, 2002
A molecular application is introduced for calculating quantum statistical mechanical expectation values of large molecules at nonzero temperatures. The Torsional Path Integral Monte Carlo (TPIMC) technique applies an uncoupled winding number formalism to
Clary, David C., Miller, Thomas F., III
core  

Thermodynamics and Kinetics of Folding of a Small Peptide

, 2001
We study the thermodynamics and kinetics of folding for a small peptide. Our data rely on Monte Carlo simulations where the interactions among all atoms are taken into account.
Hansmann, Ulrich H. E., Onuchic, Jose N.
core   +2 more sources

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M., Gallagher, S. M., Unterwald, E. M., Van Bockstaele, E. J.   +3 more
core   +2 more sources