Results 51 to 60 of about 42,525 (258)
, 2012 Well-Tempered Metadynamics (WTmetaD) is an efficient method to enhance the reconstruction of the free-energy surface of proteins. WTmetaD guarantees a faster convergence in the long time limit in comparison with the standard metadynamics.
François Sicard +2 more
core +3 more sources
Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]
, 2006 Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M. +3 more
core +2 more sources
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Effective Sampling in the Configurational Space by the Multicanonical-Multioverlap Algorithm
, 2006 We propose a new generalized-ensemble algorithm, which we refer to as the multicanonical-multioverlap algorithm. By utilizing a non-Boltzmann weight factor, this method realizes a random walk in the multi-dimensional, energy-overlap space and explores ...
B. A. Berg +5 more
core +1 more source
Chemistry &Biodiversity, EarlyView.Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández +3 more
wiley +1 more source
Biased Metropolis Sampling for Rugged Free Energy Landscapes [PDF]
, 2003 Metropolis simulations of all-atom models of peptides (i.e. small proteins) are considered. Inspired by the funnel picture of Bryngelson and Wolyness, a transformation of the updating probabilities of the dihedral angles is defined, which uses ...
Berg, Bernd A.
core +3 more sources
Chemistry – A European Journal, EarlyView.By exploiting the unique properties of 3,4,5‐trifluorophenyldiazonium salts in combination with phenols, radical arylations of tyrosine units in peptide substrates could for the first time be achieved under highly attractive conditions requiring only visible light irradiation and neither photocatalysts nor other additives, pre‐functionalization, or ...
Meret K. Kuschow +5 more
wiley +1 more source
Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]
, 1984 Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
B Sutor +11 more
core +1 more source
Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities
ChemMedChem, EarlyView.Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2007 Previous in vitro studies have shown that the degradation of [Met5]enkephalin-Arg6-Phe7 during incubation with cerebral membrane preparations is largely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon.
Shigeru Takahashi +5 more
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