Results 71 to 80 of about 47,074 (275)

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Episodic Ethanol Exposure in Adolescent Rats Causes Residual Alterations in Endogenous Opioid Peptides

Frontiers in Psychiatry, 2018
Adolescent binge drinking is associated with an increased risk of substance use disorder, but how ethanol affects the central levels of endogenous opioid peptides is still not thoroughly investigated.
Linnea Granholm, Lova Segerström, Ingrid Nylander   +2 more
doaj   +1 more source

Anti‐Inflammatory and Antibacterial Properties of Curcuma longa Extract Against Helicobacter pylori

Molecular Nutrition &Food Research, EarlyView.
This study explored the effects of Curcuma longa extract (CLE) against H. pylori infection. CLE contained 18 chemical compounds and completely inhibited growth of H. pylori Sydney strain 1 (SS1) in vitro. In infected mice with H. pylori SS1, oral administration of CLE successfully eradicated H.
Jeongsook Kim, Kwan‐Woo Kim, Jin‐Kyu Jang, Myoung Jin Kim, Akila Cooray, Young‐Seob Lee, Kyu Pil Lee, Dae Young Lee   +7 more
wiley   +1 more source

Silica‐Assisted Solid‐Phase Peptide Synthesis (SiPPS) [PDF]

J Pept Sci
The use of a non‐swelling resin for solid‐phase peptide synthesis allows the reduction of solvent consumption by up to 50%. ABSTRACT Non‐swelling silica‐based resin was used for peptide synthesis. The strategy used is similar to that of solid‐phase peptide synthesis (SPPS), referred to as silica‐assisted solid‐phase peptide synthesis (SiPPS).
Nkwanyana N, Kumar A, Chakraborty A, Potvin S, Thibaut‐Koumba G, Nardone B, Beland F, Sharma A, de la Torre B, Albericio F.   +9 more
europepmc   +2 more sources

Opioid regulation of Mu receptor internalisation: relevance to the development of tolerance and dependence [PDF]

, 2010
Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively ...
Lopez-Gimenez, J.F., Milligan, G.
core   +2 more sources

The distribution and functions of the enkephalins. [PDF]

Journal of Histochemistry & Cytochemistry, 1980
The enkephalins are two pentapeptides with pharmacological properties similar to narcotic drugs. These peptides are widely distributed in the central nervous system. The basal ganglia contain particularly high concentrations of enkaphalins. In the caudate nucleus ultrastructural studies show that enkephalin is contained within synaptic vesicles ...
Richard J. Miller, Virginia M. Pickel
openaire   +2 more sources

CNS Active O-Linked Glycopeptides that Penetrate the BBB

Frontiers in Chemistry, 2015
Naturally occurring glycopeptides and glycoproteins play important roles in biological processes. Glycosylation is one of the most common post-translational modifications in vivo.
Evan M Jones, Robin ePolt
doaj   +1 more source

N‐Geranylated Amino Acid Surfactants with Low Critical Micelle Concentrations from Abundant, Naturally Derived Starting Materials

ChemistryOpen, EarlyView.
Cleaning Up Surfactants: Realising critical micelle concentrations lower than sodium dodecyl sulfate with sustainable surfactants prepared from amino acids and naturally occurring aldehydes. In this work, a simple method for the preparation of N‐alkylated amino acid surfactants in 1–2 steps is reported.
Brett L. Pollard, Yumeng Liu, Michael G. Gardiner, Luke A. Connal   +3 more
wiley   +1 more source

Quality Control Strategies for Differentiation of Kalanchoe Species

Phytochemical Analysis, EarlyView.
ABSTRACT Kalanchoe species products are commercially available in local markets and by internationally accessible online retailers and may exhibit quality issues because of misidentification from similar common names and anatomical similarities among related species used as feedstock. This study proposes an approach using UPLC‐MS/MSE and HPTLC, coupled
Evelyn A. de Andrade, Isadora Machinski, Valter P. de Almeida, Sarah A. Barr, Wilmer H. Perera, Jane Manfron, Flávio L. Beltrame, R. Thomas Williamson, Wendy K. Strangman   +8 more
wiley   +1 more source

Asthma induced by enkephalin. [PDF]

BMJ, 1980
A total of 291 diabetics were studied to see whether an asthmatic reaction was associated with facial flushing induced by chlorpropamide and alcohol. Of these patients, 191 reported facial flushing, of whom 12 reported breathlessness as well. Of these 12, five also described wheezing, and respiratory function tests showed them to have asthma.
David Pyke, Richard David Leslie, D Bellamy   +2 more
openaire   +3 more sources