Results 101 to 110 of about 4,333 (201)
The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication [PDF]
, 2017 Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies.
Cotton, Ben T +6 more
core +2 more sources
Advanced Science, Volume 12, Issue 9, March 6, 2025.In this work, a human primary cell‐based immunocompetent model is established to investigate early responses to STm infection. Intestinal fibroblasts and monocyte‐derived macrophages are embedded in decellularized small intestinal submucosa (SIS) from domestic pigs, followed by the development of an enteroid monolayer.
Spyridon Damigos +10 more
wiley +1 more source
Frontiers in Microbiology, 2019 Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits.
Melinda A. Engevik +16 more
doaj +1 more source
Apical‐out Tubuloids for Accurate Kidney Toxicity Studies
Aggregate, Volume 6, Issue 3, March 2025.Apical‐out tubuloids are developed to study apical drug transport and drug‐induced nephrotoxicity. These tubuloids exhibit primary cilia and relevant structural proteins, indicating apical‐out polarity and enhanced functionality. Functional assays, including bovine serum albumin uptake, confirm their physiological relevance for studying apical ...
Yugyeong Lee +10 more
wiley +1 more source
Frontiers in Immunology, 2019 Type III interferon-lambda (IFN-λ) plays a critical role against infection, particularly in mucosal infection in the respiratory and gastrointestinal tract.
Liang Li +5 more
doaj +1 more source
Host-microbe interaction in the gastrointestinal tract [PDF]
, 2017 The gastrointestinal tract is a highly complex organ in which multiple dynamic physiological processes are tightly coordinated while interacting with a dense and extremely diverse microbial population.
Abrams G.D. +10 more
core +1 more source
Establishment of a Novel Caco‐2‐Based Cell Culture System for Human Sapovirus Propagation
Genes to Cells, Volume 30, Issue 2, March 2025.We identified that both Caco‐2 cells and in‐house Caco‐2/Cas9 cells are susceptible to human sapovirus (HuSaV) infection. By performing two rounds of single‐cell cloning from Caco‐2/Cas9 cells, we successfully established a highly susceptible cell line, designated as Caco‐2MC.
Yuya Fukuda +7 more
wiley +1 more source
Comparison of Surgical and Cadaveric Intestine as a Source of Crypt Culture in Humans
Cell Transplantation, 2020 Human small intestinal crypts are the source of intestinal stem cells (ISCs) that are capable of undergoing self-renewal and differentiation to an epithelial layer.
Andrew Scott +12 more
doaj +1 more source
Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection [PDF]
, 2017 Tick-borne encephalitis virus (TBEV) is a member of the genus Flavivirus. It can cause serious infections in humans that may result in encephalitis/meningoencephalitis. Although several studies have described the involvement of specific genes in the host
Grubhoffer, Libor +6 more
core +2 more sources
Lgr5+ intestinal stem cell sorting and organoid culture
Animal Models and Experimental Medicine, 2019 Intestinal epithelial stem cells (IESCs) are one of the most rapidly self‐renewing and proliferating adult stem cells. The IESCs reside at the bottom of intestinal and colonic crypts, giving rise to all intestinal epithelial lineages and maintaining ...
Ruixue Liu +4 more
doaj +1 more source