Results 91 to 100 of about 3,117 (204)

Image_10_Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.JPEG

, 2019
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and show ...
Jonathan E. Wosen (7280258), Manuel R. Amieva (7280267), Nielsen Q. Fernandez-Becker (6001403), Elizabeth D. Mellins (7280270), Calvin J. Kuo (7280264), Julia Y. Co (5964173), Alexandra Ilstad-Minnihan (4385836), Wei Jiang (14986), Dhriti Mukhopadhyay (7280261)   +8 more
core   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, Volume 4, Issue 5, October 2025.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

Image_4_Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.JPEG

, 2019
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and show ...
Jonathan E. Wosen (7280258), Manuel R. Amieva (7280267), Nielsen Q. Fernandez-Becker (6001403), Elizabeth D. Mellins (7280270), Calvin J. Kuo (7280264), Julia Y. Co (5964173), Alexandra Ilstad-Minnihan (4385836), Wei Jiang (14986), Dhriti Mukhopadhyay (7280261)   +8 more
core   +1 more source

Alistipes senegalensis is Critically Involved in Gut Barrier Repair Mediated by Panax Ginseng Neutral Polysaccharides in Aged Mice

Advanced Science, Volume 12, Issue 36, September 25, 2025.
An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang, Hui Wang, Yingna Li, Jing Lu, Xiaolei Tang, Dan Yang, Manying Wang, Daqing Zhao, Fangbing Liu, Shuai Zhang, Liwei Sun   +10 more
wiley   +1 more source

Image_2_Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.JPEG

, 2019
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, “mini-guts” derived from small intestinal crypt stem cells, and show ...
Jonathan E. Wosen (7280258), Manuel R. Amieva (7280267), Nielsen Q. Fernandez-Becker (6001403), Elizabeth D. Mellins (7280270), Calvin J. Kuo (7280264), Julia Y. Co (5964173), Alexandra Ilstad-Minnihan (4385836), Wei Jiang (14986), Dhriti Mukhopadhyay (7280261)   +8 more
core   +1 more source

Additional file 1 of Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics

, 2021
Additional file 1. Table of primer pairs. Primer details and optimized qPCR conditions.
openaire   +1 more source

The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential

Cancer Medicine, Volume 14, Issue 13, July 2025.
Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana, Md Sajedul Islam, Sujani Gamage, Alfred K. Lam, Vinod Gopalan   +4 more
wiley   +1 more source

Additional file 3 of Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics

, 2021
Additional file 3. Equine enteroid-derived 2D monolayers exposed to Poly I:C + Lipofectin (A) or Lipofectin alone (B) and the relative expression of cytokine genes (C) after 20 h stimulation. The figure shows data from one representative horse (Photo: Nikon Coolpix 990).
openaire   +1 more source

Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors

Frontiers in Microbiology, 2019
Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits.
Melinda A. Engevik, Melinda A. Engevik, Christina N. Morra, Christina N. Morra, Daniel Röth, Kristen Engevik, Jennifer K. Spinler, Jennifer K. Spinler, Sridevi Devaraj, Sridevi Devaraj, Sue E. Crawford, Mary K. Estes, Mary K. Estes, Markus Kalkum, Markus Kalkum, James Versalovic, James Versalovic   +16 more
doaj   +1 more source

Interleukin-4 suppresses the proliferation and alters the gene expression in enteroids

Cytotechnology, 2020
Interleukin (IL)-4 is known as a cytokine mainly involved in allergy and inflammation, but recent studies have suggested that IL-4 plays a part in the differentiation process of various cells. Since the effect of IL-4 on intestinal epithelial cells, particularly cryptic cells including stem cells, is poorly understood, we investigated IL-4-induced ...
Yuki, Saito, Ken, Iwatsuki, Akihiko, Inaba, Mika, Sato, Miki, Tadaishi, Makoto, Shimizu, Kazuo, Kobayashi-Hattori   +6 more
openaire   +3 more sources