PLoS ONE, 2021 Understanding the processes by which the mammalian embryo implants in the maternal uterus is a long-standing challenge in embryology. New insights into this morphogenetic event could be of great importance in helping, for example, to reduce human ...
Joel Dokmegang +4 more
semanticscholar +4 more sources
Live imaging of whole mouse embryos during gastrulation : migration analyses of epiblast and mesodermal cells [PDF]
PLoS ONE, 2013 During gastrulation in the mouse embryo, dynamic cell movements including epiblast invagination and mesodermal layer expansion lead to the establishment of the three-layered body plan.
Ichikawa, Takehiko +6 more
core +36 more sources
Generation and characterization of stable pig pregastrulation epiblast stem cell lines [PDF]
Cell Research, 2021 Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model development and livestock breeding.
Minglei Zhi +46 more
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Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning [PDF]
Science Advances, 2021 Dissecting the mechanisms of lumen formation in the epiblast revealed that the proamniotic cavity acts as a central signaling hub. During the peri-implantation stages, the mouse embryo radically changes its appearance, transforming from a hollow-shaped ...
Yung Su Kim +8 more
openalex +2 more sources
Epiblast and trophoblast morphogenesis in the pre‐gastrulation blastocyst of the pig. A light‐ and electron‐microscopical study [PDF]
Journal of morphology, 2021 The epiblast of the amniote embryo is of paramount importance during early development as it gives rise to all tissues of the embryo proper. In mammals, it emerges through segregation of the hypoblast from the inner cell mass and subsequently undergoes ...
Braah Harmoush +2 more
openalex +2 more sources
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells [PDF]
Cell, 2003 Kaoru Mitsui +8 more
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Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation [PDF]
bioRxiv, 2018 N6-methyladenosine (m6A) is the most prevalent and reversible internal modification of mammalian messenger and noncoding RNAs mediated by specific m6A writer, reader, and eraser proteins.
Tie‐Gang Meng +14 more
openalex +2 more sources
NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo [PDF]
Molecular Reproduction and Development, 2019 During preimplantation development, the embryo undergoes two consecutive lineages specifications. The first cell fate decision determines which cells give rise to the trophectoderm (TE) and the inner cell mass (ICM).
M. S. Ortega +5 more
openalex +2 more sources
ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation [PDF]
Scientific Reports, 2017 Inner cell Mass (ICM) specification into epiblast (Epi) and primitive endoderm (PrE) is an asynchronous and progressive process taking place between E3.0 to E3.75 under the control of the Fibroblast Growth Factor (FGF)/Extracellular signal-Regulated ...
Sylvain Bessonnard +5 more
openalex +2 more sources
Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells
Stem Cells, 2016 In human embryonic stem cells (ESCs) the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global transcriptional regulatory network in these cell‐fate decisions.
Agata Stryjewska +14 more
openalex +2 more sources