Results 11 to 20 of about 10,666 (158)

Epiblast cells gather onto the anterior mesendoderm and initiate brain development without the direct involvement of the node in avian embryos: Insights from broad-field live imaging

Frontiers in Cell and Developmental Biology, 2022
Live imaging of migrating and interacting cells in developing embryos has opened a new means for deciphering fundamental principles in morphogenesis and patterning, which was not possible with classic approaches of experimental embryology.
Koya Yoshihi, Hideaki Iida, Machiko Teramoto, Machiko Teramoto, Yasuo Ishii, Yasuo Ishii, Kagayaki Kato, Hisato Kondoh, Hisato Kondoh   +8 more
doaj   +1 more source

Blastomeres of 8-cell mouse embryos differ in their ability to generate embryonic stem cells and produce lines with different transcriptional signatures

Frontiers in Cell and Developmental Biology, 2023
Embryonic stem cell (ESC) derivation from single blastomeres of 8-cell mouse embryos results in lower derivation rates than that from whole blastocysts, raising a biological question about the developmental potential of sister blastomeres.
Sandra Alonso-Alonso, Anna Esteve-Codina, Anna Esteve-Codina, Beatriz Martin-Mur, Lucia Álvarez-González, Lucia Álvarez-González, Aurora Ruiz-Herrera, Aurora Ruiz-Herrera, Josep Santaló, Elena Ibáñez   +9 more
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Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Cell Reports, 2021
Summary: At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the
Matteo Amitaba Molè, Antonia Weberling, Reinhard Fässler, Alison Campbell, Simon Fishel, Magdalena Zernicka-Goetz   +5 more
doaj   +1 more source

Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development

Frontiers in Cell and Developmental Biology, 2021
From fertilization to onset of gastrulation, a mammalian embryo goes through several rounds of cellular morphogenesis resembling phenomena of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), collectively referred to as
Galym Ismagulov, Sofiane Hamidi, Guojun Sheng   +2 more
doaj   +1 more source

An in vitro stem cell model of human epiblast and yolk sac interaction

eLife, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz   +10 more
doaj   +1 more source

Establishment and optimization of the two-step induction system for generating primordial germ cell-like cells from chicken embryonic stem cells. [PDF]

FEBS Open Bio
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Li Z, Xu X, Liu G, Lv X, Song J, Sun H, Niu Y, Zuo Q, Han W, Li B, Jin K.   +10 more
europepmc   +2 more sources

BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos

BMC Biology, 2022
Background During mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified: trophectoderm (TE), epiblast, and primitive endoderm (PrE).
Mami Tsume-Kajioka, Chiharu Kimura-Yoshida, Kyoko Mochida, Yoko Ueda, Isao Matsuo   +4 more
doaj   +1 more source

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

eLife, 2018
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis   +4 more
doaj   +1 more source

Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]

PLoS ONE, 2016
Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly, James R Cooley, Sebastian L Zeltzer, Tatiana A Yatskievych, Parker B Antin   +4 more
doaj   +1 more source

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

Frontiers in Cell and Developmental Biology, 2020
Murine development demands that pluripotent epiblast stem cells in the peri-implantation embryo increase from approximately 120 to 14,000 cells between embryonic days (E) 4.5 and E7.5. This is possible because epiblast stem cells can complete cell cycles
Georgia R. Kafer, Anthony J. Cesare
doaj   +1 more source