Results 11 to 20 of about 24,147 (238)
An in vitro stem cell model of human epiblast and yolk sac interaction
eLife, 2021 Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay +10 more
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BMC Biology, 2022 Background During mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified: trophectoderm (TE), epiblast, and primitive endoderm (PrE).
Mami Tsume-Kajioka +4 more
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NANOG initiates epiblast fate through the coordination of pluripotency genes expression
Nature Communications, 2022 Pluripotent epiblast cells segregate from primitive endoderm in the blastocyst inner cell mass (ICM). Here the authors show that mosaic epiblast differentiation during mouse and human preimplantation development initiates stochastically in ICM ...
Nicolas Allègre +9 more
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PLoS ONE, 2021 Understanding the processes by which the mammalian embryo implants in the maternal uterus is a long-standing challenge in embryology. New insights into this morphogenetic event could be of great importance in helping, for example, to reduce human ...
Joel Dokmegang +4 more
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Formative pluripotent stem cells show features of epiblast cells poised for gastrulation [PDF]
Cell Research, 2021 The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively.
Xiaoxiao Wang +18 more
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Philosophical Transactions of the Royal Society of London. Biological Sciences, 2022 Using embryological data from 14 mammalian orders, the hypothesis is presented that in placental mammals, epiblast cavitation and polar trophoblast loss are alternative developmental solutions to shield the central epiblast from extraembryonic signalling.
Peter Pfeffer
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The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells [PDF]
Cell, 2003 Kaoru Mitsui +8 more
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Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation [PDF]
bioRxiv, 2020 WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue.
Robert Blassberg +6 more
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Molecular mechanism of symmetry breaking in a 3D model of a human epiblast [PDF]
bioRxiv, 2018 Breaking the anterior-posterior (AP) symmetry in mammals takes place at gastrulation. Much of the signaling network underlying this process has been elucidated in the mouse, however there is no direct molecular evidence of events driving axis formation ...
Mijo Simunovic +8 more
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Hypoblast from human pluripotent stem cells regulates epiblast development
Nature, 2023 Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos1–8.
Takumi Okubo +15 more
semanticscholar +1 more source