Results 21 to 30 of about 24,147 (238)

Capturing Pluripotency and Beyond

Cells, 2021
During the development of a multicellular organism, the specification of different cell lineages originates in a small group of pluripotent cells, the epiblasts, formed in the preimplantation embryo.
Chih-Yu Yeh, Wei-Han Huang, Hung-Chi Chen, Yaa-Jyuhn James Meir   +3 more
doaj   +1 more source

Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells

Nature Communications, 2023
Cultured meat production has emerged as a breakthrough technology for the global food industry with the potential to reduce challenges associated with environmental sustainability, global public health, animal welfare, and competition for food between ...
Gaoxiang Zhu, Dengfeng Gao, Linzi Li, Yixuan Yao, Yingjie Wang, Minglei Zhi, Jinying Zhang, Xinze Chen, Qianqian Zhu, Jie Gao, Tianzhi Chen, Xiaowei Zhang, Tong Wang, Suying Cao, Aijin Ma, Xianchao Feng, Jianyong Han   +16 more
semanticscholar   +1 more source

Epiblast cells gather onto the anterior mesendoderm and initiate brain development without the direct involvement of the node in avian embryos: Insights from broad-field live imaging

Frontiers in Cell and Developmental Biology, 2022
Live imaging of migrating and interacting cells in developing embryos has opened a new means for deciphering fundamental principles in morphogenesis and patterning, which was not possible with classic approaches of experimental embryology.
Koya Yoshihi, Hideaki Iida, Machiko Teramoto, Machiko Teramoto, Yasuo Ishii, Yasuo Ishii, Kagayaki Kato, Hisato Kondoh, Hisato Kondoh   +8 more
doaj   +1 more source

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Nature Cell Biology, 2022
WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue.
R. Blassberg, H. Patel, Thomas Watson, Mina Gouti, Vicki Metzis, M. Delás, J. Briscoe   +6 more
semanticscholar   +1 more source

Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development

Frontiers in Cell and Developmental Biology, 2021
From fertilization to onset of gastrulation, a mammalian embryo goes through several rounds of cellular morphogenesis resembling phenomena of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), collectively referred to as
Galym Ismagulov, Sofiane Hamidi, Guojun Sheng   +2 more
doaj   +1 more source

Blastomeres of 8-cell mouse embryos differ in their ability to generate embryonic stem cells and produce lines with different transcriptional signatures

Frontiers in Cell and Developmental Biology, 2023
Embryonic stem cell (ESC) derivation from single blastomeres of 8-cell mouse embryos results in lower derivation rates than that from whole blastocysts, raising a biological question about the developmental potential of sister blastomeres.
Sandra Alonso-Alonso, Anna Esteve-Codina, Anna Esteve-Codina, Beatriz Martin-Mur, Lucia Álvarez-González, Lucia Álvarez-González, Aurora Ruiz-Herrera, Aurora Ruiz-Herrera, Josep Santaló, Elena Ibáñez   +9 more
doaj   +1 more source

Generation and characterization of stable pig pregastrulation epiblast stem cell lines

Cell Research, 2021
Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model development and livestock breeding.
Minglei Zhi, Jinying Zhang, Q. Tang, Dawei Yu, Shuai Gao, Dengfeng Gao, Pengliang Liu, Jianxiong Guo, T. Hai, Jie Gao, Suying Cao, Zimo Zhao, Chongyang Li, Xiao-gang Weng, M. He, Tianzhi Chen, Yingjie Wang, K. Long, Deling Jiao, Guanglei Li, Jiaman Zhang, Yan Liu, Yu Lin, D. Pang, Qianqian Zhu, Naixin Chen, Jingjing Huang, Xinze Chen, Yixuan Yao, Jing-yun Yang, Zicong Xie, Xianya Huang, Mengxin Liu, Ran Zhang, Qiuyan Li, Yiliang Miao, Jianhui Tian, Xingxu Huang, Hongsheng Ouyang, Bofeng Liu, Wei Xie, Qi Zhou, Hongjiang Wei, Zhonghua Liu, Caihong Zheng, Mingzhou Li, Jianyong Han   +46 more
semanticscholar   +1 more source

Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]

, 2014
Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari, Masaki, Hideki, Murayama, Hideyuki, Nakauchi, Hiromitsu, Sato, Hideyuki, Yamaguchi, Tomoyuki   +5 more
core   +5 more sources

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Cell Reports, 2021
Summary: At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the
Matteo Amitaba Molè, Antonia Weberling, Reinhard Fässler, Alison Campbell, Simon Fishel, Magdalena Zernicka-Goetz   +5 more
doaj   +1 more source

Measurement of junctional tension in epithelial cells at the onset of primitive streak formation in the chick embryo via non-destructive optical manipulation [PDF]

, 2020
Directional cell intercalations of epithelial cells during gastrulation has in several organisms been shown to be associated with a planar cell polarity in the organisation of the actin-myosin cytoskeleton and is postulated to reflect directional tension
Antin, Avidan, Bachvarova, Bambardekar, Bertet, Blankenship, Campàs, Chapman, Chinthalapudi, Chuai, Clément, Collinet, Cui, Eyal-Giladi, Favre-Bulle, Fedorov, Fernandez-Gonzalez, Firmino, Gräper, Guillot, Guirao, Hamburger, Harris, Huisstede, Johansen, Lee, Montange, Neuman, Paré, Rauzi, Rauzi, Rozbicki, Sonal, Stern, Tolić-Nørrelykke, Vakaet, Voiculescu, Voiculescu, Volpe, Zallen   +39 more
core   +4 more sources