Results 21 to 30 of about 24,141 (234)

‘Neighbourhood watch’ model: embryonic epiblast cells assess positional information in relation to their neighbours

bioRxiv, 2021
In many developing and regenerating systems, tissue pattern is established through gradients of informative morphogens, but we know little about how cells interpret these.
Hyung Chul Lee, Cato Hastings, N. M. Oliveira, R. Pérez-Carrasco, Karen M. Page, Lewis Wolpert, Claudio D. Stern   +6 more
semanticscholar   +1 more source

Epiblast cells gather onto the anterior mesendoderm and initiate brain development without the direct involvement of the node in avian embryos: Insights from broad-field live imaging

Frontiers in Cell and Developmental Biology, 2022
Live imaging of migrating and interacting cells in developing embryos has opened a new means for deciphering fundamental principles in morphogenesis and patterning, which was not possible with classic approaches of experimental embryology.
Koya Yoshihi, Hideaki Iida, Machiko Teramoto, Machiko Teramoto, Yasuo Ishii, Yasuo Ishii, Kagayaki Kato, Hisato Kondoh, Hisato Kondoh   +8 more
doaj   +1 more source

Hypoblast from human pluripotent stem cells regulates epiblast development

Nature, 2023
Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos1–8.
Takumi Okubo, Nicolas Rivron, Mio Kabata, Hideki Masaki, Keiko Kishimoto, Katsunori Semi, May Nakajima‐Koyama, Haruko Kunitomi, Belinda Kaswandy, Hideyuki Sato, Hiromitsu Nakauchi, K. Woltjen, Mitinori Saitou, Erika Sasaki, Takuya Yamamoto, Yasuhiro Takashima   +15 more
semanticscholar   +1 more source

Capturing Pluripotency and Beyond

Cells, 2021
During the development of a multicellular organism, the specification of different cell lineages originates in a small group of pluripotent cells, the epiblasts, formed in the preimplantation embryo.
Chih-Yu Yeh, Wei-Han Huang, Hung-Chi Chen, Yaa-Jyuhn James Meir   +3 more
doaj   +1 more source

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Nature Cell Biology, 2022
WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue.
R. Blassberg, H. Patel, Thomas Watson, Mina Gouti, Vicki Metzis, M. Delás, J. Briscoe   +6 more
semanticscholar   +1 more source

Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development

Frontiers in Cell and Developmental Biology, 2021
From fertilization to onset of gastrulation, a mammalian embryo goes through several rounds of cellular morphogenesis resembling phenomena of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), collectively referred to as
Galym Ismagulov, Sofiane Hamidi, Guojun Sheng   +2 more
doaj   +1 more source

Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Cell Research, 2021
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively.
Xiaoxiao Wang, Yunlong Xiang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang, Xiaoqing Wang, Xukun Lu, Dan-Dan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh‐Chang, Hongmei Wang, N. Jing, Wei Xie, Lei Li   +18 more
semanticscholar   +1 more source

Blastomeres of 8-cell mouse embryos differ in their ability to generate embryonic stem cells and produce lines with different transcriptional signatures

Frontiers in Cell and Developmental Biology, 2023
Embryonic stem cell (ESC) derivation from single blastomeres of 8-cell mouse embryos results in lower derivation rates than that from whole blastocysts, raising a biological question about the developmental potential of sister blastomeres.
Sandra Alonso-Alonso, Anna Esteve-Codina, Anna Esteve-Codina, Beatriz Martin-Mur, Lucia Álvarez-González, Lucia Álvarez-González, Aurora Ruiz-Herrera, Aurora Ruiz-Herrera, Josep Santaló, Elena Ibáñez   +9 more
doaj   +1 more source

Alternative mammalian strategies leading towards gastrulation: losing polar trophoblast (Rauber's layer) or gaining an epiblast cavity

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2022
Using embryological data from 14 mammalian orders, the hypothesis is presented that in placental mammals, epiblast cavitation and polar trophoblast loss are alternative developmental solutions to shield the central epiblast from extraembryonic signalling.
P. Pfeffer
semanticscholar   +1 more source

Live imaging of avian epiblast and anterior mesendoderm grafting reveals the complexity of cell dynamics during early brain development

Development, 2022
Despite previous intensive investigations on epiblast cell migration in avian embryos during primitive streak development before stage (st.) 4, this migration at later stages of brain development has remained uninvestigated.
Koya Yoshihi, Kagayaki Kato, Hideaki Iida, Machiko Teramoto, Akihito Kawamura, Y. Watanabe, Mitsuo Nunome, Mikiharu Nakano, Yoichi Matsuda, Yuki Sato, Hidenobu Mizuno, T. Iwasato, Y. Ishii, H. Kondoh   +13 more
semanticscholar   +1 more source