Results 21 to 30 of about 10,666 (158)

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

eLife, 2015
Early mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development.
Jan J Zylicz, Sabine Dietmann, Ufuk Günesdogan, Jamie A Hackett, Delphine Cougot, Caroline Lee, M Azim Surani   +6 more
doaj   +1 more source

Sox2 Level Is a Determinant of Cellular Reprogramming Potential. [PDF]

PLoS ONE, 2013
Epiblast stem cells (EpiSCs) and embryonic stem cells (ESCs) differ in their in vivo differentiation potential. While ESCs form teratomas and efficiently contribute to the development of chimeras, EpiSCs form teratomas but very rarely chimeras.
Dong Wook Han, Natalia Tapia, Marcos J Araúzo-Bravo, Kyung Tae Lim, Kee Pyo Kim, Kinarm Ko, Hoon Taek Lee, Hans R Schöler   +7 more
doaj   +1 more source

Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

Biology Open, 2019
Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate.
Antonio Barral, Isabel Rollan, Hector Sanchez-Iranzo, Wajid Jawaid, Claudio Badia-Careaga, Sergio Menchero, Manuel J. Gomez, Carlos Torroja, Fatima Sanchez-Cabo, Berthold Göttgens, Miguel Manzanares, Julio Sainz de Aja   +11 more
doaj   +1 more source

Specific epiblast loss and hypoblast impairment in cattle embryos sensitized to survival signalling by ubiquitous overexpression of the proapoptotic gene BAD. [PDF]

PLoS ONE, 2014
Early embryonic lethality is common, particularly in dairy cattle. We made cattle embryos more sensitive to environmental stressors by raising the threshold of embryo survival signaling required to overcome the deleterious effects of overexpressing the ...
Jessica van Leeuwen, Debra K Berg, Craig S Smith, David N Wells, Peter L Pfeffer   +4 more
doaj   +1 more source

Human ES Cell Culture Conditions Fail to Preserve the Mouse Epiblast State

Stem Cells International, 2021
Mouse embryonic stem cells (mESCs) and mouse epiblast stem cells (mEpiSCs) are the pluripotent stem cells (PSCs), derived from the inner cell mass (ICM) of preimplantation embryos at embryonic day 3.5 (E3.5) and postimplantation embryos at E5.5-E7.5 ...
A. S. Devika, Anna Montebaur, S. Saravanan, Raghu Bhushan, Frederic Koch, Smita Sudheer   +5 more
doaj   +1 more source

Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells. [PDF]

PLoS ONE, 2016
Fibroblast growth factor 5 (Fgf5) has been widely used as a marker for the epiblast in the postimplantation embryo and epiblast stem cells (mEpiSCs) in the mouse, making it valuable for study of differentiation of various tissues and epiblast cells in ...
Le Tran Phuc Khoa, Takuya Azami, Tomoyuki Tsukiyama, Jun Matsushita, Setsuko Tsukiyama-Fujii, Satoru Takahashi, Masatsugu Ema   +6 more
doaj   +1 more source

Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

eLife, 2022
The epiblast of vertebrate embryos is comprised of neural and non-neural ectoderm, with the border territory at their intersection harboring neural crest and cranial placode progenitors.
Ruth M Williams, Martyna Lukoseviciute, Tatjana Sauka-Spengler, Marianne E Bronner   +3 more
doaj   +1 more source

NANOG initiates epiblast fate through the coordination of pluripotency genes expression

Nature Communications, 2022
Pluripotent epiblast cells segregate from primitive endoderm in the blastocyst inner cell mass (ICM). Here the authors show that mosaic epiblast differentiation during mouse and human preimplantation development initiates stochastically in ICM ...
Nicolas Allègre, Sabine Chauveau, Cynthia Dennis, Yoan Renaud, Dimitri Meistermann, Lorena Valverde Estrella, Pierre Pouchin, Michel Cohen-Tannoudji, Laurent David, Claire Chazaud   +9 more
doaj   +1 more source

Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation.

PLoS ONE, 2021
Understanding the processes by which the mammalian embryo implants in the maternal uterus is a long-standing challenge in embryology. New insights into this morphogenetic event could be of great importance in helping, for example, to reduce human ...
Joel Dokmegang, Moi Hoon Yap, Liangxiu Han, Matteo Cavaliere, René Doursat   +4 more
doaj   +1 more source

Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification

eLife
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants.
Nikola Sekulovski, Jenna C Wettstein, Amber E Carleton, Lauren N Juga, Linnea E Taniguchi, Xiaolong Ma, Sridhar Rao, Jenna K Schmidt, Thaddeus G Golos, Chien-Wei Lin, Kenichiro Taniguchi   +10 more
doaj   +1 more source