Results 31 to 40 of about 24,141 (234)

Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]

, 2014
Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari, Masaki, Hideki, Murayama, Hideyuki, Nakauchi, Hiromitsu, Sato, Hideyuki, Yamaguchi, Tomoyuki   +5 more
core   +5 more sources

Human naive epiblast cells possess unrestricted lineage potential

bioRxiv, 2020
Classical mouse embryology has established a paradigm of early development driven by sequential lineage bifurcations. Accordingly, mouse embryonic stem cells derived from early epiblast have lost the potency to produce extraembryonic trophectoderm.
G. Guo, G. Stirparo, S. Strawbridge, D. Spindlow, Jian Yang, James Clarke, Anish Dattani, A. Yanagida, M. Li, Samuel Myers, Buse Nurten Özel, J. Nichols, Austin G Smith   +12 more
semanticscholar   +1 more source

High‐throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming

Stem Cells Translational Medicine, 2021
Epiblast stem cells (EpiSCs) derived from postimplantation epiblast are pluripotent stem cells, epigenetically distinct from embryonic stem cells (ESCs), which are widely used in reprogramming studies.
Q. Gao, Wenhao Zhang, Yiding Zhao, Yaru Tian, Yuna Wang, Jinxin Zhang, Mengyang Geng, Mei-lin Xu, Chunmeng Yao, Haoyu Wang, Luyuan Li, Yan Liu, L. Shuai   +12 more
semanticscholar   +1 more source

BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos

BMC Biology, 2022
Background During mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified: trophectoderm (TE), epiblast, and primitive endoderm (PrE).
Mami Tsume-Kajioka, Chiharu Kimura-Yoshida, Kyoko Mochida, Yoko Ueda, Isao Matsuo   +4 more
doaj   +1 more source

Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells [PDF]

PLoS ONE, 2016
Fibroblast growth factor 5 (Fgf5) has been widely used as a marker for the epiblast in the postimplantation embryo and epiblast stem cells (mEpiSCs) in the mouse, making it valuable for study of differentiation of various tissues and epiblast cells in ...
Le Tran Phuc Khoa, Takuya Azami, Tomoyuki Tsukiyama, Jun Matsushita, Setsuko Tsukiyama-Fujii, Satoru Takahashi, Masatsugu Ema   +6 more
openalex   +3 more sources

Spatially resolved cell polarity proteomics of a human epiblast model

Science Advances, 2021
APEX2-based spatial proteomics identifies cell polarity proteome of hPSC-cysts, a 3D model of human epiblast cavity formation. Critical early steps in human embryonic development include polarization of the inner cell mass, followed by formation of an ...
Sicong Wang, Chien-Wei Lin, Amber E. Carleton, Chari L. Cortez, Craig Johnson, Linnea E. Taniguchi, Nikola Sekulovski, Ryan F. Townshend, V. Basrur, A. Nesvizhskii, Peng Zou, Jianping Fu, D. Gumucio, Mara C. Duncan, Kenichiro Taniguchi   +14 more
semanticscholar   +1 more source

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

eLife, 2018
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis   +4 more
doaj   +1 more source

Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]

PLoS ONE, 2016
Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly, James R Cooley, Sebastian L Zeltzer, Tatiana A Yatskievych, Parker B Antin   +4 more
doaj   +1 more source

TFAP2C regulates transcription in human naive pluripotency by opening enhancers. [PDF]

, 2018
Naive and primed pluripotent human embryonic stem cells bear transcriptional similarity to pre- and post-implantation epiblast and thus constitute a developmental model for understanding the pluripotent stages in human embryo development. To identify new
Chen, Di, Clark, Amander T, Ho, Jamie, Hunt, Timothy J, Jacobsen, Steven E, Kim, Rachel, Liu, Wanlu, Liu, Xiaodong, Lukianchikov, Anastasia, Pastor, William A, Polo, Jose M   +10 more
core   +2 more sources

Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation

Biology Open, 2019
Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate.
Antonio Barral, Isabel Rollan, Hector Sanchez-Iranzo, Wajid Jawaid, Claudio Badia-Careaga, Sergio Menchero, Manuel J. Gomez, Carlos Torroja, Fatima Sanchez-Cabo, Berthold Göttgens, Miguel Manzanares, Julio Sainz de Aja   +11 more
doaj   +1 more source