Results 31 to 40 of about 24,147 (238)
Development, 2022 The early specification and rapid growth of extraembryonic membranes are distinctive hallmarks of primate embryogenesis. These complex tasks are resolved through an intricate combination of signals controlling the induction of extraembryonic lineages and,
Clara Munger +9 more
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Development, 2022 Despite previous intensive investigations on epiblast cell migration in avian embryos during primitive streak development before stage (st.) 4, this migration at later stages of brain development has remained uninvestigated.
Koya Yoshihi +13 more
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Human naive epiblast cells possess unrestricted lineage potential
bioRxiv, 2020 Classical mouse embryology has established a paradigm of early development driven by sequential lineage bifurcations. Accordingly, mouse embryonic stem cells derived from early epiblast have lost the potency to produce extraembryonic trophectoderm.
G. Guo +12 more
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Science Advances, 2021 Dissecting the mechanisms of lumen formation in the epiblast revealed that the proamniotic cavity acts as a central signaling hub. During the peri-implantation stages, the mouse embryo radically changes its appearance, transforming from a hollow-shaped ...
Y. S. Kim +8 more
semanticscholar +1 more source
Spatially resolved cell polarity proteomics of a human epiblast model
Science Advances, 2021 APEX2-based spatial proteomics identifies cell polarity proteome of hPSC-cysts, a 3D model of human epiblast cavity formation. Critical early steps in human embryonic development include polarization of the inner cell mass, followed by formation of an ...
Sicong Wang +14 more
semanticscholar +1 more source
eLife, 2018 During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani +4 more
doaj +1 more source
bioRxiv, 2021 Directed differentiation of pluripotent stem cells (PSCs) is a powerful model system for deconstructing embryonic development. Although mice are the most advanced mammalian model system for genetic studies of embryonic development, state-of-the-art ...
Daniel Medina-Cano +7 more
semanticscholar +1 more source
Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]
PLoS ONE, 2016 Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly +4 more
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Current perspectives of the signaling pathways directing neural crest induction. [PDF]
, 2012 The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I +1 more
core +2 more sources
Stem Cells Translational Medicine, 2021 Epiblast stem cells (EpiSCs) derived from postimplantation epiblast are pluripotent stem cells, epigenetically distinct from embryonic stem cells (ESCs), which are widely used in reprogramming studies.
Q. Gao +12 more
semanticscholar +1 more source