Results 51 to 60 of about 24,141 (234)

Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation [PDF]

, 2017
In cattle early gastrulation-stage embryos (Stage 5), four tissues can be discerned: (i) the top layer of the embryonic disc consisting of embryonic ectoderm (EmE); (ii) the bottom layer of the disc consisting of mesoderm, endoderm and visceral hypoblast
Berg, D, Maclean, P, Pfeffer, P, Smith, C   +3 more
core   +2 more sources

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Cell Reports, 2021
Summary: At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the
Matteo Amitaba Molè, Antonia Weberling, Reinhard Fässler, Alison Campbell, Simon Fishel, Magdalena Zernicka-Goetz   +5 more
doaj  

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]

, 2018
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David, Delling, Markus, Klein, Ophir D, McKinley, Kara L, Royer, Loic A, Schartner, Christoph, Stuurman, Nico, Vale, Ronald D   +7 more
core   +1 more source

Epiblast Ground State Is Controlled by Canonical Wnt/β-Catenin Signaling in the Postimplantation Mouse Embryo and Epiblast Stem Cells [PDF]

PLoS ONE, 2013
Epiblast stem cells (EpiSCs) are primed pluripotent stem cells and can be derived from postimplantation mouse embryos. We now show that the absence of canonical Wnt/β-catenin signaling is essential for maintenance of the undifferentiated state in mouse ...
Tomoyuki Sumi, Shinya Oki, Keiko Kitajima, Chikara Meno   +3 more
openalex   +3 more sources

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Nature Communications, 2015
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown.
Benjamin S. Freedman, Craig R. Brooks, A. Q. Lam, Hongxia Fu, Ryuji Morizane, Vishesh Agrawal, A. F. Saad, Michelle K. Li, Michael R. Hughes, R. V. Werff, Derek T. Peters, Junjie Lu, Anna Baccei, Andrew M. Siedlecki, M. T. Valerius, K. Musunuru, K. McNagny, Theodore I. Steinman, Jing Zhou, P. Lerou, J. Bonventre   +20 more
semanticscholar   +1 more source

Modeling mammalian gastrulation with embryonic stem cells

, 2017
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and ...
Amita, Arnold, Azioune, Bauwens, Bedzhov, Ben-Haim, Bernardo, Blin, Bolouri, Chambers, Coucouvanis, Dunn, Engler, Etoc, Farin, Gjorevski, Green, Gurdon, Harrison, Heemskerk, Heemskerk, Horii, Lee, Lei, Li, Lippmann, Loh, Meinhardt, Meinhardt, Mendjan, Migeotte, Müller, Nakamura, Nallet-Staub, Nemashkalo, Nemashkalo, Nowotschin, Pagliuca, Peerani, Perea-Gomez, Przybyla, Qin, Ranga, Rosowski, Saka, Sasai, Schohl, Shao, Shao, Simunovic, Sorre, Sun, Tang, ten Berge, Teo, Tewary, Théry, Turing, Turner, Turner, van den Brink, Warmflash, Wilson, Xu, Yang, Yu   +65 more
core   +1 more source

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

bioRxiv
Studies in the mouse demonstrate the importance of fibroblast growth factor (FGF) and extra-cellular receptor tyrosine kinase (ERK) in specification of embryo-fated epiblast and yolk-sac-fated hypoblast cells from uncommitted inner cell mass (ICM) cells ...
Claire S. Simon, Afshan McCarthy, Laura Woods, Desislava P. Staneva, Qiulin Huang, Madeleine Linneberg-Agerholm, Alex Faulkner, Athanasios Papathanasiou, Kay Elder, Phil Snell, Leila Christie, Patricia Garcia, Valerie Shaikly, Mohamed Taranissi, Meenakshi Choudhary, Mary Herbert, J. Brickman, K. Niakan   +17 more
semanticscholar   +1 more source

MCRS1 is essential for epiblast development during early mouse embryogenesis.

Reproduction, 2020
Microspherule protein 1 (MCRS1, also known as MSP58) is an evolutionarily conserved protein that has been implicated in various biological processes. Although a variety of functions have been attributed to MCRS1 in vitro, mammalian MCRS1 has not been ...
Wei Cui, Agnes Cheong, Yongsheng Wang, Yuran Tsuchida, Yong Liu, K. Tremblay, J. Mager   +6 more
semanticscholar   +1 more source

The early stages of heart development: insights from chicken embryos [PDF]

, 2016
The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan, Arguello, de la Cruz, de La Cruz, de la Cruz, DeHaan, Hatada, Kitajima, Le Lievre, Needham, Plein, Psychoyos, Rosenquist, Schultheiss, Stern, Tam, Vincent, Waldo, Yatskievych, Zhang   +19 more
core   +2 more sources

Asymmetry in the frequency and position of mitosis in the mouse embryo epiblast at gastrulation

EMBO Reports, 2020
At gastrulation, a subpopulation of epiblast cells constitutes a transient posteriorly located structure called the primitive streak, where cells that undergo epithelial–mesenchymal transition make up the mesoderm and endoderm lineages.
Navrita Mathiah, Evangéline Despin-Guitard, M. Stower, Wallis Nahaboo, Elif Sema Eski, S. P. Singh, S. Srinivas, I. Migeotte   +7 more
semanticscholar   +1 more source