Results 61 to 70 of about 24,141 (234)

Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation

bioRxiv, 2020
WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue.
R. Blassberg, H. Patel, Thomas Watson, Mina Gouti, Vicki Metzis, Joaquina Delás, J. Briscoe   +6 more
semanticscholar   +1 more source

Integration of Bioengineered Tools in Assisted Reproductive Technologies

Advanced Healthcare Materials, EarlyView.
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak, Edith Coonen, Ron van Golde, Erik Vrij   +3 more
wiley   +1 more source

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast

Development, 2017
Single-cell profiling techniques create opportunities to delineate cell fate progression in mammalian development. Recent studies have provided transcriptome data from human pre-implantation embryos, in total comprising nearly 2000 individual cells ...
G. Stirparo, Thorsten E. Boroviak, G. Guo, J. Nichols, Austin G Smith, Paul Bertone   +5 more
semanticscholar   +1 more source

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

Cell Reports, 2016
Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency.
Dario Acampora, Daniela Omodei, Giuseppe Petrosino, Arcomaria Garofalo, Marco Savarese, Vincenzo Nigro, Luca Giovanni Di Giovannantonio, Vincenzo Mercadante, Antonio Simeone   +8 more
doaj   +1 more source

Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm [PDF]

, 2018
Networks of interacting co-regulated genes distinguish the inner cell mass (ICM) from the differentiated trophectoderm (TE) in the preimplantation blastocyst, in a species specific manner.
Bates, Nicola, Brison, Daniel R., Garner, Terence, Kimber, Susan J., Minogue, Ben, Oldershaw, Rachel, Shaw, Lisa, Smith, Helen, Sneddon, Sharon, Stevens, Adam   +9 more
core   +1 more source

Large‐Scale Bioprinting of Human Epiblast‐Like Models Featuring Disc‐Shaped Morphogenesis and Gastrulation Events

Advanced Science, EarlyView.
Large‐scale generation of disc‐shaped models mimicking human epiblast layer is achieved by bioprinting of human pluripotent stem cells using a well‐defined biomatrix. The bioactive component and physical confinement from laminin/alginate microgels, combined with the endogenous regulation of the WNT signaling pathway regulated disc‐like morphogenesis ...
Yixue Luo, Liheng Luo, Ling Wang, Shanshan Yang, Hongan Ren, Shaojun Liang, Xiaoyu Wang, Yijun Su, Leqian Yu, Xiaoyue Wang, Mingen Xu, Rui Yao   +11 more
wiley   +1 more source

Epiblast formation by Tead-Yap-dependent expression of pluripotency factors and competitive elimination of unspecified cells

bioRxiv, 2018
The epiblast is a pluripotent cell population first formed in preimplantation embryos and its quality is important for proper development. Here, we examined the mechanisms of epiblast formation and found that the Hippo pathway transcription factor Tead ...
Masakazu Hashimoto, H. Sasaki
semanticscholar   +1 more source

A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation

Cell Reports, 2015
Differentiating pluripotent epiblast cells in eutherians undergo random X-inactivation, which equalizes X-linked gene expression between the sexes by silencing one of the two X-chromosomes in females. Tsix RNA is believed to orchestrate the initiation of 
Srimonta Gayen, Emily Maclary, Emily Buttigieg, Michael Hinten, Sundeep Kalantry   +4 more
doaj   +1 more source

Simulating the Mammalian Blastocyst - Molecular and Mechanical Interactions Pattern the Embryo [PDF]

, 2011
Mammalian embryogenesis is a dynamic process involving gene expression and mechanical forces between proliferating cells. The exact nature of these interactions, which determine the lineage patterning of the trophectoderm and endoderm tissues occurring ...
A Jedrusik, A Ralston, A Ralston, B Plusa, C Chazaud, Carsten Peterson, Denis Thieffry, E Palsson, F Graner, H Honda, H Niwa, H Niwa, J Rossant, JC Dallon, JE Dietrich, K Cockburn, K Piotrowska, K Piotrowska-Nitsche, K Piotrowska-Nitsche, M Bischoff, M Eyiyurekli, M Zernicka-Goetz, N Motosugi, N Nishioka, Pawel Krupinski, RA Foty, RL Gardner, SJ Kimber, SM Meilhac, T Fujimori, V Chickarmane, V Chickarmane, VB Alarcón, Vijay Chickarmane, Y Kurotaki, Y Marikawa, Y Yamanaka   +36 more
core   +4 more sources

Pre‐oviposition development of the brown anole (Anolis sagrei)

Developmental Dynamics, EarlyView.
Abstract Background The brown anole, Anolis sagrei, has emerged as a representative squamate species for developmental studies during the past decades. Novel functional tools have been established to manipulate embryogenesis through genome editing or the introduction of small molecule inhibitors, and their effective use requires a thorough ...
Antonia Weberling, Natalia A. Shylo, Bonnie K. Kircher, Hannah Wilson, Melainia McClain, Marta Marchini, Katherine B. Starr, Thomas J. Sanger, Florian Hollfelder, Paul A. Trainor   +9 more
wiley   +1 more source