Results 61 to 70 of about 13,289,951 (302)

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Network Analysis Reveals Tea Catechins as Multi-Target Inhibitors of Colon Adenocarcinoma

JRST: Jurnal Riset Sains dan Teknologi
Colon cancer is the second most common cause of cancer death worldwide. It drives the need for effective prevention and treatment strategies, including identifying new and inventive targets for treating colon cancer.
Anwar Rovik, Dyah Fitri Kusharyati
doaj   +1 more source

Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells-5

, 2011
(62 kDa) of BZR cells incubated with different concentrations of EGCG (0, 5 and 7.5 μg/ml). A significant EGCG dose-dependent decrease (p < 0.05) of pro-MMP2 form was observed compared to control.
Myriam Polette (58028), Magali Milliot (58025), Christine Terryn (58026), Philippe Birembaut (58029), Jérôme Cutrona (58027), Salma Hazgui (58022), Jean-Marie Zahm (27105), Arnaud Bonnomet (58023), Béatrice Nawrocki-Raby (58024)   +8 more
core   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Catechin profile and hypolipidemic activity of Morinda citrifolia leaf water extract

Heliyon, 2020
Cardiovascular diseases (CVDs) are silent killers and hyperlipidemia is a high-risk factor. Morinda citrolia leaf (MCL), which is commonly consumed by many cultural groups and has high level of catechins, might exert antihyperlipidemic properties.
Chong Kah Hui, Nurul Izwanie Majid, Hayati Mohd Yusof, Khairi Mohd Zainol, Habsah Mohamad, Zamzahaila Mohd Zin   +5 more
doaj   +1 more source

Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells-3

, 2011
Ch color on the figure corresponds to different cells. A longer distance of migration was observed for control BZR cells compared with BZR cells treated with EGCG.
Myriam Polette (58028), Magali Milliot (58025), Christine Terryn (58026), Philippe Birembaut (58029), Jérôme Cutrona (58027), Salma Hazgui (58022), Jean-Marie Zahm (27105), Arnaud Bonnomet (58023), Béatrice Nawrocki-Raby (58024)   +8 more
core   +1 more source

(−)-Epigallocatechin-3-gallate, a Polyphenol from Green Tea, Regulates the Liquid–Liquid Phase Separation of Alzheimer’s-Related Protein Tau

, 2023
The microtubule-associated protein tau is involved in Alzheimer’s disease and other tauopathies. Recently, tau has been shown to undergo liquid–liquid phase separation (LLPS), which is implicated in the physiological function and pathological aggregation
Jingxin Chen (6921974), Zhengding Su, Meng Gao, Wanyao Ma (14491707), Yongqi Huang (135385), Hongling Qian, Yongqi Huang, Yue Han (560788), Yue Han, Xi Wang, Zhengding Su (1697299), Jiangchuan Yu, Haiqiong Ye (14491713), Wanyao Ma, Jiangchuan Yu (11616307), Ping Li, Jingxin Chen, Xi Wang (15032), Hongling Qian (14491710), Meng Gao (399324), Haiqiong Ye, Ping Li (31981)   +21 more
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Binding of epigallocatechin‐3‐gallate to transthyretin modulates its amyloidogenicity [PDF]

FEBS Letters, 2009
MINT‐7294529: TTR (uniprotkb:P02766) and TTR (uniprotkb:P02766) bind (MI:0407) by comigration in non‐denaturing gel electrophoresis (MI:0404)
Ferreira, Nelson, Cardoso, Isabel, Domingues, Maria Rosário, Vitorino, Rui, Bastos, Margarida, Bai, Guangyue, Saraiva, Maria João, Almeida, Maria Rosário   +7 more
openaire   +2 more sources

Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells-4

, 2011
of EGCG. A progressive inhibition of the mRNA level for MMP2 and no changes in MT1-MMP and u-PA mRNA level were observed in parallel with the increase of EGCG concentration.
Myriam Polette (58028), Magali Milliot (58025), Christine Terryn (58026), Philippe Birembaut (58029), Jérôme Cutrona (58027), Salma Hazgui (58022), Jean-Marie Zahm (27105), Arnaud Bonnomet (58023), Béatrice Nawrocki-Raby (58024)   +8 more
core   +1 more source