Results 51 to 60 of about 208,229 (162)

Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry, 2023
Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li, Xiaofen Zong, David Li, Ying He, Jinsong Tang, Maolin Hu, Xiaogang Chen   +6 more
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Aged Worms Erase Epigenetic History [PDF]

Cell Metabolism, 2011
Defining the molecular events that precipitate multisystem decline is an important component of aging research. In this issue, Jin et al. (2011) show that increased expression of the histone demethylase, utx-1, causes genome-wide decreases in histone H3K27 trimethylation, which includes the insulin/IGF-1 signaling (IIS) pathway that promotes aging.
Lunyak, Victoria V., Kennedy, Brian K.
openaire   +2 more sources

An epigenetic clock for human skeletal muscle

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues.
Sarah Voisin, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Vernon G. Coffey, Thomas M. Doering, Jamie‐Lee M. Thompson, Christian Benedict, Jonathan Cedernaes, Malene E. Lindholm, Jeffrey M. Craig, David S. Rowlands, Adam P. Sharples, Steve Horvath, Nir Eynon   +15 more
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Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study

International Journal of General Medicine, 2023
Germán Alberto Nolasco-Rosales,1,* Cecilia Yazmin Alonso-García,1,* David Gustavo Hernández-Martínez,1 Mario Villar-Soto,2 José J Martínez-Magaña,3 Alma Delia Genis-Mendoza,4 Thelma Beatriz González-Castro,5 Carlos Alfonso Tovilla-Zarate,6 ...
Nolasco-Rosales GA, Alonso-García CY, Hernández-Martínez DG, Villar-Soto M, Martínez-Magaña JJ, Genis-Mendoza AD, González-Castro TB, Tovilla-Zarate CA, Guzmán-Priego CG, Martínez-López MC, Nicolini H, Juárez-Rojop IE   +11 more
doaj  

Ageing, Drosophila melanogaster and Epigenetics

Malaysian Journal of Medical Sciences, 2020
Ageing is a phenomenon where the accumulation of all the stresses that alter the functions of living organisms, halter them from maintaining their physiological balance and eventually lead to death. The emergence of epigenetic tremendously contributed to the knowledge of ageing.
Halim, Mardani Abdul, Tan, Florence Hui Ping, Azlan, Azali, Rasyid, Ian Ilham, Rosli, Nurlina, Shamsuddin, Shaharum, Azzam, Ghows   +6 more
openaire   +2 more sources

Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder

Frontiers in Genetics
Mathematical algorithms known as “epigenetic clocks” use methylation values at a set of CpG sites to estimate the biological age of an individual in a tissue-specific manner. These clocks have demonstrated both acceleration and delays in epigenetic aging
Gauri G. Shastri, Gauri G. Shastri, Gustavo Sudre, Kwangmi Ahn, Benjamin Jung, Bhaskar Kolachana, Pavan K. Auluck, Laura Elnitski, Philip Shaw, Philip Shaw   +9 more
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Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array

Clinical Epigenetics, 2018
Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods.
Lisa M McEwen, Meaghan J Jones, David Tse Shen Lin, Rachel D Edgar, Lucas T Husquin, Julia L MacIsaac, Katia E Ramadori, Alexander M Morin, Christopher F Rider, Chris Carlsten, Lluís Quintana-Murci, Steve Horvath, Michael S Kobor   +12 more
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Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer

Epigenetics
Breast cancer is the most common cancer diagnosed in women and is often treated with chemotherapy. Although previous studies have demonstrated increasing biological age in patients who receive chemotherapy, evaluation of this association with DNA ...
Drew R. Nannini, Rene Cortese, Christopher VonTungeln, Gerhard C. Hildebrandt   +3 more
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Investigating the Relationship between Epigenetic Age and Cardiovascular Risk in a Population with Overweight/Obesity

Biomedicines
Introduction: Cardiovascular diseases stand as the leading global cause of mortality. Major modifiable risk factors encompass overweight/obese conditions, high blood pressure, elevated LDL cholesterol, diabetes, smoking, secondhand smoke exposure ...
Davide Marinello, Chiara Favero, Benedetta Albetti, Davide Barbuto, Luisella Vigna, Angela Cecilia Pesatori, Valentina Bollati, Luca Ferrari   +7 more
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Epigenetic age acceleration and clinical outcomes in gliomas.

PLoS ONE, 2020
Epigenetic age acceleration-the difference between an individual's DNA methylation age and chronological age-is associated with many diseases including cancer. This study aims to evaluate epigenetic age acceleration as a prognostic biomarker for gliomas.
Chunlei Zheng, Nathan A Berger, Li Li, Rong Xu   +3 more
doaj   +1 more source