Results 61 to 70 of about 6,200 (160)

MethAgingDB: a comprehensive DNA methylation database for aging biology

Scientific Data
Accurately quantifying biological age is crucial for understanding the mechanisms of aging and developing effective interventions. Molecular aging clocks, particularly epigenetic clocks that use DNA methylation data to estimate biological age, have ...
Siyu Li, Songming Tang, Haocheng Ma, Haixin Wang, Shengquan Chen   +4 more
doaj   +1 more source

Epigenetic aging clocks in mice and men

Genome Biology, 2017
Genome biology 18(1), 107 (2017).
openaire   +4 more sources

Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers

Clinical Epigenetics
Background The sex chromosome aneuploidies Turner syndrome (45,X; TS) and Klinefelter syndrome (47,XXY; KS) are associated with aging-related comorbidities, reduced life expectancy and genome-wide DNA methylation changes.
Emma B. Hasselholm, Jesper Just, Simon Chang, Anne Skakkebæk, Claus Højbjerg Gravholt   +4 more
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ComputAgeBench: Epigenetic Aging Clocks Benchmark

Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.2
AbstractThe success of clinical trials of longevity drugs relies heavily on identifying integrative health and aging biomarkers, such as biological age. Epigenetic aging clocks predict the biological age of an individual using their DNA methylation profiles, commonly retrieved from blood samples.
Dmitrii Kriukov, Evgeniy Efimov, Ekaterina Kuzmina, Anastasiia Dudkovskaia, Ekaterina E. Khrameeva, Dmitry V. Dylov   +5 more
openaire   +1 more source

Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age

Genome Biology
Epigenetic aging signatures provide insights into human aging, but traditional clocks rely on linear regression of DNA methylation levels, assuming linear trajectories.
Juan-Felipe Perez-Correa, Thomas Stiehl, Riccardo E. Marioni, Janie Corley, Simon R. Cox, Ivan G. Costa, Wolfgang Wagner   +6 more
doaj   +1 more source

Epigenetic age and cardiometabolic disease in Guatemalan adults: a cross-sectional analysis

Journal of Health, Population and Nutrition
Background Epigenetic clocks, biomarkers of aging, show older biological ages among individuals with cardiometabolic disease. Epigenetic age acceleration, often calculated as the residuals from regressing epigenetic age on chronological age, reflects ...
Melissa A. Chapnick, Elaine A. Yu, Alicia K. Smith, Karen N. Conneely, Manuel Ramírez-Zea, Zhaohui S. Qin, Lisa R. Staimez, Viola Vaccarino, Aryeh D. Stein   +8 more
doaj   +1 more source

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Nature Communications, 2018
Epigenetic clocks based on DNA methylation levels are estimators of chronological age. Here, the authors perform a GWAS of epigenetic aging rates in blood and find SNP variants in the TERT locus associated with increased intrinsic epigenetic age are also
Ake T. Lu, Luting Xue, Elias L. Salfati, Brian H. Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M. Murabito, Douglas P. Kiel, Pei-Chien Tsai, Idil Yet, Jordana T. Bell, Massimo Mangino, Toshiko Tanaka, Allan F. McRae, Riccardo E. Marioni, Peter M. Visscher, Naomi R. Wray, Ian J. Deary, Morgan E. Levine, Austin Quach, Themistocles Assimes, Philip S. Tsao, Devin Absher, James D. Stewart, Yun Li, Alex P. Reiner, Lifang Hou, Andrea A. Baccarelli, Eric A. Whitsel, Abraham Aviv, Alexia Cardona, Felix R. Day, Nicholas J. Wareham, John R. B. Perry, Ken K. Ong, Kenneth Raj, Kathryn L. Lunetta, Steve Horvath   +38 more
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Sleep traits causally affect epigenetic age acceleration: a Mendelian randomization study

Scientific Reports
Sleep disorders (SDs) are a common issue in the elderly. Epigenetic clocks based on DNA methylation (DNAm) are now considered highly accurate predictors of the aging process and are associated with age-related diseases.
Wen Zhao, Shiyao Yu, Yan Xu, Huijuan Liao, Daiyi Chen, Ting Lu, Zhixuan Ren, Lijuan Ge, Jianhui Liu, Jingbo Sun   +9 more
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Sequencing method matters: differential performance of DNA methylation data acquisition in epigenetic clock calibration

Journal of Avian Biology
Age is an important trait, influencing an individual's physiology, behavior, and survival probability. Unfortunately, the ages of wild animals are often unknown, impeding behavioral and ecological studies requiring life history information and impacting ...
Livia Gerber, Aaron W. Schrey, Susan C. Anderson, Erena Jain, Andrea L. Liebl   +4 more
doaj   +1 more source

Causal association between epigenetic age acceleration and two pulmonary vascular diseases: pulmonary arterial hypertension and pulmonary embolism—a bidirectional Mendelian study

Clinical Epigenetics
Background Pulmonary arterial hypertension (PAH) is a relatively rare but severe disease with a poor prognosis. Pulmonary embolism (PE) is a serious condition that can cause sudden death.
Jun Tong, Chuanxue Wan, An Wang, Mengqi Chen, Binqian Ruan, Jieyan Shen   +5 more
doaj   +1 more source