Results 251 to 260 of about 1,306,054 (295)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

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Epigenetic Effects of Psychoactive Drugs

Current Pharmaceutical Design, 2023
Abstract: Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in the loss of hundreds of thousands of lives annually. Besides alcohol and opioid use and misuse, there has been an increase in illicit abuse of psychostimulants.
Rania, Ahmed, Kenneth, Blum, Panayotis K, Thanos   +2 more
openaire   +2 more sources

Epigenetics in Drug Response

Clinical Pharmacology & Therapeutics, 2016
Hereditary genetic variation has been identified to contribute significantly to drug response. More recently, there is increasing evidence that individual phenotypic differences may also result from epigenetic alterations such as histone‐acetylation or DNA‐methylation.
I, Cascorbi, M, Schwab
openaire   +2 more sources

Drug discovery for epigenetics targets

Drug Discovery Today, 2022
Dysregulation of the epigenome is associated with the onset and progression of several diseases, including cancer, autoimmune, cardiovascular, and neurological disorders. Members from the three families of epigenetic proteins (readers, writers, and erasers) have been shown to be druggable using small-molecule inhibitors.
Geoffrey A, Holdgate, Catherine, Bardelle, Alice, Lanne, Jon, Read, Daniel H, O'Donovan, James M, Smith, Nidhal, Selmi, Robert, Sheppard   +7 more
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Epigenetics in Drug Discovery: Achievements and Challenges

2021
The epigenome comprises a range of covalent modifications of DNA and histone proteins that establish chromatin structure and function. These processes regulate gene expression without altering the DNA sequence and play an important role in regulating, e.g. brain function and associated behaviours.
Korda, Ziva, Pishva, Ehsan, Hove, Daniel L.A.   +2 more
openaire   +1 more source

Common non-epigenetic drugs as epigenetic modulators

Trends in Molecular Medicine, 2013
Epigenetic effects are exerted by a variety of factors and evidence increases that common drugs such as opioids, cannabinoids, valproic acid, or cytostatics may induce alterations in DNA methylation patterns or histone conformations. These effects occur via chemical structural interactions with epigenetic enzymes, through interactions with DNA repair ...
Jörn, Lötsch, Gisbert, Schneider, Daniel, Reker, Michael J, Parnham, Petra, Schneider, Gerd, Geisslinger, Alexandra, Doehring   +6 more
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Targeting Epigenetics in Drug Discovery

ChemMedChem, 2014
This Special Issue of ChemMedChem on Epigenetics and Drug Discovery brings together a diverse group of papers on a range of topics from bromodomain inhibitors and long noncoding RNAs to classic agents targeting histone deacetylases (HDACs) and less typical HDAC inhibitors, such as the chimeric compounds designed by Greg Thatcher et al.
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